104 results about "Phenylacetones" patented technology

The present invention provides, among other things, methods of treating phenylketonuria (PKU), including administering to a subject in need of treatment a composition comprising an mRNA encoding phenylalanine hydroxylase (PAH) at an effective dose and an administration interval such that at least one symptom or feature of PKU is reduced in intensity, severity, or frequency or has delayed in onset. In some embodiments, the mRNA is encapsulated in a liposome comprising one or more cationic lipids, one or more non-cationic lipids, one or more cholesterol-based lipids and one or more PEG-modified lipids.

Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and / or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, [e.g., treating hyperphenylalaninemia, (including phenylketonuria)], and other disorders (including cancer).

Disclosed are crystalline forms of sepiapterin free base selected from polymorphs A, B, C, D, E, F, and G, and combinations thereof, as well as crystalline polymorphs of salts of sepiapterin. Also disclosed are pharmaceutical compositions containing one or more such polymorphs and methods for preparing such polymorphs. Sepiapterin is useful in the treatment of a number diseases associated with low cellular levels of BH4, for example, phenylketonuria.

Medical foods containing glycomacroprotein and additional supplemented amounts of arginine, leucine, and optionally other amino acids, such as tyrosine, are disclosed. The medical foods can be used to provide the complete protein requirements for patients having metabolic disorders such as phenylketonuria.

The invention discloses a water-solubility polyphenylene sulfide which has a structure formula as shown in the specification. The polyphenylene sulfide dissolves in water and saturated salt water and does not dissolve in methyl pyrrolidone, dimethylacetylamide, tetrahydrofuran, toluene, acetone, chloroform and ethanol; or the polyphenylene sulfide dissolves in the water and the saturated salt water, slightly dissolves in methyl pyrrolidone, dimethylacetylamide and ethanol, and does not dissolve in tetrahydrofuran, toluene, acetone and chloroform, wherein R is N<+>(CH3)3CL<->, NH<+>(CH3)2CL<->, N<+>(CH2CH2OH)3CL<-> and NH<+>(CH2CH2OH)2CL<->. Or the invention further discloses a preparation method of the water-solubility polyphenylene sulfide. The water-solubility polyphenylene sulfide prepared by the invention has the advantages of good water-solubility, temperature resistance and salt resistance, can be expected to not only broaden application of the water-solubility polyphenylene sulfide in the field of water-solubility functional polymer but also is applied to the fields with worst working environment, such as oil field, paper making, waste water treatment and the like.