Method for extracting and separating curcumin

A technology for separating curcumin and curcumin, applied in the separation/purification of carbonyl compounds, organic chemistry, etc., can solve the problems of large amount of organic solvent, high production cost, and curcumin content of only 95%, and achieve high product purity, The effect of reducing costs and improving resource utilization

Inactive Publication Date: 2014-02-12
HUNAN KEYUAN BIO PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of the organic solvent extraction method is that the amount of organic solvent is huge, the production cost is high, and the content of curcumin produced is only 95%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] This embodiment includes the following steps:

[0016] (1) Extraction: take 100 grams of turmeric, grind it to 80 mesh, add 800 grams of sodium hydroxide aqueous solution with a mass concentration of 5%, stir and extract at 25°C for 4 hours, filter to obtain an alkaline water extract;

[0017] (2) Degreasing: add 600 grams of petroleum ether to the alkaline water extract, stir and extract for 1.5 hours, then let stand for 1.5 hours, separate the upper layer of petroleum ether, and remove the fat-soluble substances in the extract (concentrated petroleum ether layer, Get the by-product - turmeric oil 9 g);

[0018] (3) Acid precipitation: adjust the pH of the extract treated in step (2) to 2 with hydrochloric acid to precipitate curcumin, filter, and dry to constant weight to obtain 6.2 grams of curcumin crude product with a content of 85.6% (high-efficiency liquid phase external standard method);

[0019] (4) Refining: Dissolve 6.2 grams of crude curcumin in 60 grams o...

Embodiment 2

[0021] This embodiment includes the following steps:

[0022] (1) Extraction: Take 200 grams of turmeric, grind it to 80 mesh, add 2000 grams of sodium carbonate aqueous solution with a mass concentration of 9%, stir and extract at 30°C for 5 hours, filter to obtain an alkaline water extract;

[0023] (2) Degreasing: Add 2000 grams of toluene to the alkaline water extract, stir and extract for 1.5 hours, then let stand for 1.5 hours, separate the upper toluene layer, and remove the fat-soluble substances in the extract (concentrate the toluene layer to obtain the by-product- turmeric oil 21 g);

[0024] (3) Acid precipitation: After the treatment in step (2), adjust the pH to 2 with hydrochloric acid to precipitate curcumin, filter, and dry to constant weight to obtain 12.6 grams of crude curcumin with a content of 87.5% (HPLC external standard Law);

[0025] (4) Refining: Dissolve 12.6 grams of crude curcumin in 150 grams of ethanol, filter, add 200 grams of distilled water...

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Abstract

The invention discloses a method for extracting and separating curcumin. The method comprises the following steps: (1) extraction: crushing curcuma longa, adding 2-10% alkaline water to extract to obtain an alkaline water extracting solution; (2) degreasing: adding an organic solvent petroleum ether, 6# solvent oil, cyclohexane, benzene, methylbenzene or ethyl acetate into the alkaline water extracting solution, stirring and extracting for 1-2h, and then, standing for 1-2h to separate out an organic layer; (3) acid deposition: regulating the pH value of the extracting solution to 1-2 by using hydrochloric acid to separate out the curcumin, filtering, and drying to constant weight to obtain a crude product of the curcumin; and (4) dissolving the crude product of the curcumin by using an organic solvent methanol, ethanol, acetone, n-butanol or isopropanol, filtering, adding distilled water into the filtrate, carrying out freezing crystallization at the temperature of 0-5 DEG C for 2-8h, filtering, and drying to obtain a curcumin product. The method is low in production cost; the prepared curcumin product is high in purity up to over 98.5%.

Description

technical field [0001] The invention relates to a method for extracting and separating curcumin. Background technique [0002] Turmeric is rich in Southeast Asian countries and regions, and it is widely used in foreign diet and medical treatment. The origin of turmeric is also distributed in China. Curcumin, an important ingredient in turmeric, is a natural pigment. Domestic manufacturers of curcumin generally use organic solvent extraction. The disadvantage of the organic solvent extraction method is that the amount of organic solvent is huge, the production cost is high, and the content of curcumin produced is only 95%. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a method for extracting and separating curcumin which not only has low production cost but also has high content of curcumin in the obtained product. [0004] The technical solution adopted by the present invention to solve its technical problems...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/255C07C45/78C07C45/81
CPCC07C45/78C07C49/255
Inventor 李伟刘志强
Owner HUNAN KEYUAN BIO PRODS
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