The invention provides an MVR crystallization salification grain control system and a control method. The system comprises a forced circulation pump, a crystallizer discharging pump, an elutriation circulating pump, a control system, a forced circulation heat exchanger, an Oslo crystallizer and an elutriation separator, wherein a circulating liquid outlet is connected with a heat exchange inlet, aheat exchange outlet is connected with a circulating liquid inlet, a crystallization material liquid outlet is connected with a crystallization material liquid inlet through the crystallizer discharging pump, an elutriation clear liquid outlet is connected with a elutriation clear liquid inlet, a mother solution outlet is further connected to a connecting pipeline of a circulating liquid outlet and the forced circulation pump and is connected with a mother solution inlet through the elutriation circulating pump, and the control system is connected with the forced circulation pump, the crystallizer discharging pump and the elutriation circulating pump, respectively. The crystallizer is of an Oslo structure, the elutriation separator is additionally arranged, and the grains are primarily screened in the crystallizer and are further elutriated and screened by virtue of the elutriation separator, so that the quality of the product is guaranteed.