Online measurement device for crystal size and shape in high-solid-content crystallization process

A technology for measuring device and crystal size, which is applied in the direction of measuring device, crystallization separation, solution crystallization, etc. It can solve the problem of difficult on-line measurement of crystal shape and size distribution, so as to reduce the influence of disturbance, realize recycling and avoid pipeline blockage. Effect

Active Publication Date: 2021-03-12
QINGDAO UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide an on-line measurement device for crystal size and shape in the crystallization process with high solid content, so as to solve the above-mentioned problems in the p

Method used

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  • Online measurement device for crystal size and shape in high-solid-content crystallization process
  • Online measurement device for crystal size and shape in high-solid-content crystallization process
  • Online measurement device for crystal size and shape in high-solid-content crystallization process

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Example Embodiment

[0053] Example 1L-glutamic acid - aqueous cooled crystallization process, 4L crystal crystal crystal solution 3L, solution temperature 50 ° C, stirring rate of 250 rpm, crystal average size 80-150 μm, solid content 10%. The peristaltic pump is used by Masterflex L / S, the pipeline is a latex tube, a inner diameter of 3.2mm, wall thickness; through insulation cotton insulation; solution amplifier is a light-transmitting glass material, the constant temperature tank is a glass material, the heating solution is water, Keep 52 ° C; the online image system camera and the light source are placed in the constant temperature slot to align the solution amplifier on both sides, and the light source and the camera are focused on the solution amplifier. Adjust the sharpness of the image system and control the flow rate of the crystal in the solution by the peristaltic pump, the process is about 100 rpm; the crystal solution circulating in the solution amplifier is collected. Measurement resu...

Example Embodiment

[0054] Example 2L-glutamic acid - water intermittent cooling crystallization process, 10L crystal kettle crystal solution 7L, solution temperature 50 ° C, stirring rate 150 rpm, crystal average size 150-200 μm, solid content 20%. The peristaltic pump is used by Masterflex L / S, the pipeline is a latex tube, an inner diameter of 4.6 mm, wall thickness 1.6mm; through insulation cotton insulation; the solution amplifier is a light-transmitted glass material, the constant temperature tank is a glass material, the heating solution is water, Keep 52 ° C; the online image system camera and the light source are placed in the constant temperature slot to align the solution amplifier on both sides, and the light source and the camera are focused on the solution amplifier. Adjust the sharpness of the image system and control the flow rate of the crystal in the solution by the peristaltic pump, the process is about 100 rpm; the crystal solution circulating in the solution amplifier is collec...

Example Embodiment

[0055] Example 3 Potassium dihydrogen phosphate (KDP) intermittently cooled crystallization process, 4L crystalline kettle 3L, solution temperature 50 ° C, stirring rate of 250 rpm, crystal average size of 100-200 μm, solid content of 15%. The peristaltic pump is used by Masterflex L / S, the pipeline is a latex tube, a inner diameter of 3.2mm, wall thickness; through insulation cotton insulation; solution amplifier is a light-transmitting glass material, the constant temperature tank is a glass material, the heating solution is water, Keep 51 ° C; the online image system camera and the light source are placed in the constant temperature slot to align the solution amplifier on both sides, and the light source and the camera are focused on the solution amplifier. Adjust the sharpness of the image system and control the flow rate of the crystal in the solution by the peristaltic pump, the process is about 100 rpm; the crystal solution circulating in the solution amplifier is collect...

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Abstract

The invention discloses an online measurement device for the size and shape of a crystal in a high-solid-content crystallization process. The online measurement device comprises a solution amplifier,a measurement device, a peristaltic pump, a crystallization kettle, a dilution device and a liquid storage tank, a crystal-containing solution is arranged in the crystallization kettle; the inner wallof the solution amplifier is smooth, one end is an amplification end, and the other end is a contraction end; the contraction end of the solution amplifier is communicated with one end of the liquidstorage tank and one end of the crystallization kettle; the amplification end of the solution amplifier is respectively communicated with the dilution device and the peristaltic pump; the peristalticpump is communicated with the other end of the crystallization kettle; the solution amplifier, the peristaltic pump and the crystallization kettle form a complete passage through a pipeline; a measuring instrument of the measuring device is arranged in the outer side of the solution amplifier and focuses on the solution in the amplification end of the solution amplifier; and at least one stop valve is mounted on each branch of the pipeline. According to the invention, measurement of a crystalline solution with solid content higher than 10% is realized; and the pipeline heat preservation and constant-temperature tank is designed, so that the problems of solution crystallization on the pipe wall and pipeline blockage are avoided.

Description

technical field [0001] The invention relates to the technical field of on-line measurement of industrial crystallization, in particular to an on-line measurement device for crystal size and shape during crystallization with high solid content. Background technique [0002] As an important means of separation and purification, crystallization technology is widely used in pharmaceutical, chemical, food and other industries (Z.Gao, et al.Engineering, 2017.3:343-353; H.Lorenz, et al.Chem.Eng.Technol., 2017.40:1210). The existing methods for measuring the shape and size distribution of the crystallization process mainly include FBRM, laser particle size analyzer, ultrasonic method and image method, wherein the crystal shape mainly adopts the online image method (Xue Z.Wang, Crystal growth measurement using 2D and 3D imaging and the perspectives for shapecontrol. Chemical Engineering Science. 2008). However, the literature (Nagy et.al., Recent advances in the monitoring, modelin...

Claims

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Application Information

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IPC IPC(8): G01N15/02G01N21/84B01D9/02
CPCG01N15/02G01N15/0205G01N15/0227G01N21/84B01D9/00G01N2015/0294G01N2021/8477B01D9/0013B01D9/0059B01D9/0077B01D9/0063G01N15/1463G01N2015/1493G01N2015/1497B01D2009/0086G01N15/1404G01N15/1434
Inventor 张方坤艾自东吴兵单宝明
Owner QINGDAO UNIV OF SCI & TECH
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