Control and monitoring of non-resonant radiation-induced nucleation, crystallization, and polymorph formation

A polymorphic, non-resonant technology that is used in laser writing to encode information, evaluate polymorph formation, and the field of polymorphs, which can solve problems such as hindering analysis
CN101084049AInactive Publication Date: 2007-12-05CHEMIMAGE CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHEMIMAGE CORP
Publication Date
2007-12-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to methods of assessing the polymorphic form of a substance by assessing Raman-shifted radiation scattered by a particle of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials. The invention also relates to methods of selecting and controlling polymorph formation by illuminating a material with non-resonant (i.e., non-absorbed) laser radiation as it is thermally driven through a phase transition temperature.
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Description

Background of the invention

[0001] The present invention generally relates to the field of compositional analysis of solid particles.

[0002] Many compounds can exist in multiple discrete crystalline forms. For example, graphite and diamond are dispersed crystalline forms of elemental carbon. The property of being able to assume polymorphic forms is often referred to as polymorphism, and different crystal forms of the same compound are termed polymorphs, or more simply, polymorphisms. Polymorphs of a single compound generally have chemical properties that differ at least slightly. For example, polymorphs can exhibit differences in melting point, electrical conductivity, radiation absorption pattern, X-ray diffraction pattern, crystal shape, dissolution rate, and solubility, even when polymorphs are composed of the same chemical species.

[0003] In the context of pharmaceutically active compounds, differences between polymorphs can affect the pharmacological properties of ...

Claims

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