The invention discloses a
ceftazidime continuous preparation method, comprising the following steps: S1, preparing a
ceftazidime dihydrochloride solution; S2, preparing a
sodium hydroxide solution; S3, preparing a
phosphoric acid solution; S4, respectively adding the
ceftazidime dihydrochloride solution and the
sodium hydroxide solution into a high-speed centrifugal mixer at a certain flow rate for
rapid mixing, and then flowing out from the outlet of the high-speed centrifugal mixer to obtain a ceftazidime solution 1; S5, adding a suspension of ceftazidime
crystal seeds and water into a crystallizer A, and simultaneously continuously and uniformly adding the ceftazidime solution 1 and the
phosphoric acid solution; S6, when the volume of the
crystallization liquid in the crystallizer A exceeds 100 ml, the
crystallization liquid automatically overflows from the crystallizer A and flows into the crystallizer B, and the crystals are grown in the crystallizer B for a period of time, filtered, washed and dried to obtain a ceftazidime product. The invention can significantly reduce the content of impurities, especially the
impurity content of RRT=0.82, improve the purity, and the
powder particle size is uniform.