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Artificial bone material and preparation method thereof

An artificial bone and raw material technology, applied in the field of materials, can solve the problems of low bending strength, cannot be repaired with bone defects, high crystallinity, achieve high porosity, meet individual needs, improve biocompatibility and mechanical strength Effect

Active Publication Date: 2013-09-11
珠海市红旌发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nano-hydroxyapatite is a bioceramic material, which inevitably has some performance defects, such as brittleness, low bending strength, and cannot be used for the repair of bone defects in weight-bearing parts. degradation and absorption

Method used

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  • Artificial bone material and preparation method thereof
  • Artificial bone material and preparation method thereof
  • Artificial bone material and preparation method thereof

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preparation example Construction

[0025] The preparation method of the artificial bone material in the present invention includes two methods, namely a solution blending method and a melt blending method.

[0026] Wherein, the preparation method of solution blending method is as follows:

[0027] First enter step S1100 to prepare hydroxyapatite: the preparation concentration is 0.025-0.2mol / l containing Ca 2+ Solution, according to the ratio of Ca / P molar ratio of 1.67, will contain Ca 2+ The solution was dropped into H 3 PO 4 solution, then adjust the pH to 7-10 with an alkaline solution, age for 24-48 hours, wash, dry at 105°C for 2-4 days, and grind to obtain hydroxyapatite. Wherein, the said Ca 2+ The solution is CaCl 2 or Ca (NO 3 ) 2 . The alkaline solution is ammonia water or sodium hydroxide. The solvent is any one of the following: chloroform, tetrahydrofuran and 1,4-dioxane. Then enter step S1200 to prepare hydroxyapatite / polylactic acid / nanocellulose composite material: dissolve polylactic...

Embodiment 1

[0032] figure 1 A method for preparing an artificial bone material according to one embodiment of the present invention is shown.

[0033] First enter step S1100 to prepare hydroxyapatite: the preparation concentration is 0.2mol / l Ca(NO 3 ) 2 Solution 20ml, according to the ratio of Ca / P molar ratio is 1.67, Ca(NO 3 ) 2Slowly drop the solution into 24ml with a concentration of 0.1mol / lH 3 PO 4 solution, and then adjust the pH to 8 with ammonia solution to form a hydroxyapatite gel, which is aged for 24 hours, washed, and dried in a drying oven at 105°C for 2 days to obtain nano-sized hydroxyapatite powder .

[0034] Then go to step S1200 to prepare hydroxyapatite / polylactic acid / nanocellulose composite material: dissolve polylactic acid in 1,4-dioxane, prepare 10ml of a solution with a concentration of 5%, and add the nanocellulose prepared in step S1100 The hydroxyapatite and the nanocellulose with a mass percentage of 1% were vigorously stirred and blended, then dried...

Embodiment 2

[0036] figure 1 A method for preparing an artificial bone material according to one embodiment of the present invention is shown.

[0037] First enter step S1100 to prepare hydroxyapatite: prepare CaCl with a concentration of 0.05mol / l 2 Solution 100ml, according to the ratio that Ca / P molar ratio is 1.67, while stirring, CaCl 2 The solution was slowly dripped into 30ml of H with a concentration of 0.1mol / l 3 PO 4 solution, and then use sodium hydroxide solution to adjust the pH to 7.5 to form a hydroxyapatite gel, which is aged for 24 hours, washed, dried in a drying oven at 105°C for 2 days, and ground to obtain nano-sized hydroxyapatite stone powder.

[0038] Then enter step S1200 to prepare hydroxyapatite / polylactic acid / nanocellulose composite material: dissolve polylactic acid in tetrahydrofuran to prepare a 16ml solution with a concentration of 3%, and add the nano-hydroxyapatite and mass percentage prepared in step S1100 1% nano-cellulose was vigorously stirred an...

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Abstract

The invention discloses a preparation method of an artificial bone material. Provided raw materials comprise hydroxyapatite, polylactic acid and nano-crystalline cellulose. The preparation method comprises: dissolving polylactic acid in a solvent to prepare a polylactic acid solution with a mass percent concentration of 1-5%; adding nano-crystalline cellulose and hydroxyapatite into the polylactic acid solution, stirring and blending, drying for 10-24 h at a temperature of 105 DEG C, grinding to obtain the artificial bone material. The preparation method also can comprise: adding polylactic acid, nano-crystalline cellulose and hydroxyapatite into an extruder and carrying out melt blending for 5-20 min, extruding at a temperature of 175-185 DEG C, smashing to obtain the artificial bone material. The material has excellent bioactivity, biocompatibility, bone conductivity, high porosity, good pore connectivity, high intensity and good mechanical property, and can be taken as a substituted material of an artificial bone or other hard tissues, and is also applicable to 3D printing.

Description

technical field [0001] The invention relates to a material, in particular to an artificial bone material and a preparation method thereof. Background technique [0002] Bone defects caused by accidents or diseases are common clinical cases. At present, the commonly used repair materials include autologous bone, allogeneic bone and artificial bone synthetic materials. These materials are insufficient to a certain extent and cannot fully meet the clinical needs. Natural bone itself is a composite material of nano-hydroxyapatite and collagen, so nano-hydroxyapatite has become the most important bone repair and replacement material. The artificial bone material made of nano-hydroxyapatite can replace Ca and P through normal metabolic pathways after being implanted into the human body, and can achieve perfect affinity with human tissues through the hydrogen bond formed by hydroxyl groups, and has excellent biocompatibility. There is no immune rejection phenomenon, and it is an a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/46
Inventor 蓝海时圣涛任方萍黎国康
Owner 珠海市红旌发展有限公司
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