The invention relates to a freeze-
drying treatment process suitable for a
bioactive coating. The freeze-
drying treatment process comprises the following factors:
coating freeze-
drying pretreatment: preparing an
excipient and an auxiliary material solution; in the pre-freezing part, the pre-freezing temperature, the shelf temperature before feeding and the pre-freezing time are determined; the freeze-
drying time part comprises the fastest temperature point of one-time sublimation drying, the
drying time of a high-speed section of one-time sublimation, the
drying time of a low-speed section of one-time sublimation and the
desorption drying time. And the vacuum degree part is one-time sublimation air
doping amount. The method is simple, the technology is mature and feasible, the freeze-dried
coating product is regular in appearance and extremely low in
water content, the defects of an existing
bioactive coating preparation technology are overcome, the actual application requirement is met, the drying technology in most
bioactive coating preparation processes can be replaced, the
biological activity of the
coating is guaranteed, the service life of the coating is prolonged, and the application prospect is wide. The industrial application of the coating is facilitated, and powerful support is provided for related research.