Preparation method of piezoelectric ceramic/bone cement biological piezoelectric composite material

A technology of piezoelectric composite materials and piezoelectric ceramics, applied in ceramic products, tissue regeneration, application, etc., can solve problems such as poor bone conductivity and high piezoelectric phase content

Active Publication Date: 2018-05-18
XIAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to provide a preparation method of piezoelectric ceramic/bone cement bio-piezoelectric composite ma

Method used

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  • Preparation method of piezoelectric ceramic/bone cement biological piezoelectric composite material
  • Preparation method of piezoelectric ceramic/bone cement biological piezoelectric composite material
  • Preparation method of piezoelectric ceramic/bone cement biological piezoelectric composite material

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preparation example Construction

[0032] A preparation method of a piezoelectric ceramic / bone cement biological piezoelectric composite material of the present invention comprises the following steps:

[0033] Step 1, prepare piezoelectric porous scaffold:

[0034] Step 1.1, weigh the following components according to volume percentage: piezoelectric ceramic powder 10%-30%, dispersant 1%-2%, binder 0.8%-1%, distilled water 67%-88.2%, the above components The sum of volume percentage is 100%;

[0035] In step 1.1, the piezoelectric ceramic powder is any one of barium titanate, calcium titanate, lithium sodium potassium niobate, potassium sodium niobate, bismuth sodium titanate, barium calcium zirconate titanate; the dispersant It is any one of sodium dodecylbenzenesulfonate, sodium polyacrylate, citric acid, polymethacrylic acid, sodium polymethacrylate; the binder is polyvinyl alcohol, polyvinylpyrrolidone, carboxymethyl One of cellulose and gum arabic;

[0036]Step 1.2, mix the components weighed in step 1...

Embodiment 1

[0052] Step 1: Preparation of Piezoelectric Porous Scaffold

[0053] Take 10% of barium titanate powder, 1% of sodium dodecylbenzenesulfonate, 0.8% of polyvinyl alcohol, and 88.2% of distilled water according to the volume percentage. The volume percentage of each of the above components is 100%. After removing air bubbles in a vacuum environment, pour into a mold, freeze at -75°C for 2 hours, dry in a vacuum environment for 48 hours, and finally sinter at 1300°C for 2 hours to obtain a piezoelectric porous scaffold with a volume fraction of 30%;

[0054] Step 2: Preparation of calcium phosphate bone cement precursor

[0055] Take 30% of calcium hydrogen phosphate and 70% of tetracalcium phosphate according to the mass percentage, and the sum of the mass percentages of the above components is 100%, mix evenly to obtain the solid phase of calcium phosphate bone cement; take 64% of the solid phase of calcium phosphate bone cement according to the mass percentage , 36% phosphate...

Embodiment 2

[0061] Step 1: Preparation of Piezoelectric Porous Scaffold

[0062] Take 30% potassium sodium niobate powder, 2% citric acid, 1% polyvinylpyrrolidone, and 67% distilled water according to the volume percentage. The volume percentage of the above components is 100%. Mix the above ingredients evenly, and remove air bubbles in a vacuum environment Finally, pour it into the mold, freeze at -75°C for 2 hours, dry it in a vacuum environment for 48 hours, and finally sinter at 1300°C for 2 hours to obtain a piezoelectric porous scaffold with a volume fraction of 55%;

[0063] Step 2: Preparation of calcium phosphate bone cement precursor

[0064] Take 35% of calcium hydrogen phosphate and 65% of tetracalcium phosphate according to the mass percentage, and the sum of the mass percentages of the above components is 100%, mix evenly to obtain the solid phase of calcium phosphate bone cement; take 67% of the solid phase of calcium phosphate bone cement according to the mass percentage ...

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Abstract

The invention discloses a preparation method of a piezoelectric ceramic/bone cement biological piezoelectric composite material. The method includes the steps of: 1, preparation of a piezoelectric porous scaffold; 2, preparation of a calcium phosphate bone cement precursor; 3, preparation of a biological piezoelectric composite material preform; and 4, self-curing and polarization, thus finally obtaining the piezoelectric ceramic/bone cement biological piezoelectric composite material. The method provided by the invention solves the problems that: existing biological piezoelectric materials have a high piezoelectric phase content, osteoconduction is poor in the cell growth process; by employing the traditional physical blending to reduce the piezoelectric content, the piezoelectric coefficient is low and cannot reach a bone induction effect; and common sintering of hydroxyapatite and biological piezoelectric ceramic cannot achieve optimal material performance.

Description

technical field [0001] The invention relates to the technical field of preparation methods of biomedical materials, in particular to a preparation method of a piezoelectric ceramic / bone cement bio-piezoelectric composite material. Background technique [0002] Every year due to diseases or traffic accidents, millions of patients around the world need to undergo bone graft surgery, thus promoting the research and development of bone substitute materials. Bone substitute materials are synthesized from bone-like matrix components, all of which have good biocompatibility, not only can be well integrated with the surrounding recipient bone tissue, but also some artificial bone materials can be stably degraded. In addition, the biggest advantage of artificial bone material is that its own composition and performance can be adjusted arbitrarily, and it can not only retain good biocompatibility without any immune reaction. Bone substitute materials are mostly composed of calcium-ph...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/10A61L27/12A61L27/56C04B38/00C04B35/465C04B35/468C04B35/495C04B35/475C04B35/49C04B41/85
CPCA61L27/10A61L27/12A61L27/50A61L27/56A61L2430/02C04B35/465C04B35/4682C04B35/475C04B35/49C04B35/495C04B38/0605C04B41/5092C04B41/85C04B2235/656C04B41/4539
Inventor 汤玉斐段子豪赵康吴聪
Owner XIAN UNIV OF TECH
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