Preparation method of micron or nanometer calcium phosphate/catechol-based polymer bone repair scaffold

A nano-calcium phosphate and catechol-based technology, applied in the fields of medical science and prostheses, can solve the problems of uniform distribution of fibers and carbon nanotubes, inability to use 3D printing methods, and limited improvement of material mechanical properties, etc., to achieve Avoid adverse effects, good biocompatibility, and improve the effect of mechanical properties

Inactive Publication Date: 2014-04-02
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the mixing in a solid state, it is difficult to distribute the fibers and carbon nanotubes uniformly, resulting in limited improvement in the mechanical properties of the material.
And because the fiber or carbon nanotube itself is not viscous, it can only be molded or poured to form a bracket, but cannot be formed by 3D printing, and cannot be made into a bracket with an inner cavity or a fine special shape and structure

Method used

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  • Preparation method of micron or nanometer calcium phosphate/catechol-based polymer bone repair scaffold
  • Preparation method of micron or nanometer calcium phosphate/catechol-based polymer bone repair scaffold
  • Preparation method of micron or nanometer calcium phosphate/catechol-based polymer bone repair scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A method for preparing micro- and nano-calcium phosphate / catechol-based polymer bone repair scaffolds, the steps are:

[0034] A. Combine 85 parts by weight of alpha tricalcium phosphate with an average particle diameter of 500 μm, 10 parts by weight of dibasic calcium phosphate dihydrate with an average particle diameter of 500 μm, and 5 parts by weight of hydroxyapatite with an average particle diameter of 500 μm. One part by weight of pore former—mannitol is mixed with 20 parts by weight of polydopamine, and trihydroxyaminomethane-hydrochloric acid buffer is added to obtain a slurry mixture;

[0035] B. The slurry mixture of step A is molded by molding, and then placed in a 37°C water bath for curing for 24 hours.

[0036] The polydopamine of this example was prepared by the following method:

[0037] Dopamine was added to the potassium hydroxide solution of pH 8.5, stirred for 24 hours under the condition of oxygen gas, and then the solution was centrifuged and freeze-dried...

Embodiment 2

[0041] A method for preparing micro- and nano-calcium phosphate / catechol-based polymer bone repair scaffolds, the steps are:

[0042] A. Mix 100 parts by weight of α-type tricalcium phosphate with an average particle size of 1μm, 40 parts by weight of pore former-hydrogen peroxide and 0.1 part by weight of polydopamine, and then add trihydroxyaminomethane-hydrochloric acid buffer to obtain a slurry mixture;

[0043] B. The slurry mixture of step A is molded by pouring, and then placed in a 35°C water bath for curing for 20 hours after molding.

[0044] The polydopamine of this example was prepared by the following method:

[0045] Add dopamine to the pH10 sodium hydroxide solution, stir for 24h under UV irradiation, and then centrifuge and freeze-dry the solution.

Embodiment 3

[0047] A method for preparing micro- and nano-calcium phosphate / catechol-based polymer bone repair scaffolds, the steps are:

[0048] A. Mix 100 parts by weight of β-tricalcium phosphate with an average particle size of 500μm, 1 part by weight of pore former-degradable polymer and 45 parts by weight of polydopamine, and then add trihydroxyaminomethane-hydrochloric acid buffer to obtain Slurry mixture

[0049] B. The slurry mixture of step A is molded by molding, and then placed in a 40°C water bath for curing for 30 hours.

[0050] The polydopamine of this example was prepared by the following method:

[0051] Add dopamine to the pH7.4 sodium hydroxide solution, add sodium periodate, stir for 24h, then centrifuge the solution and freeze-dry it to obtain.

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Abstract

The invention discloses a preparation method of a micron or nanometer calcium phosphate / catechol-based polymer bone repair scaffold. The preparation method comprises the following steps: A, mixing 100 parts by weight of calcium phosphate, 1-40 parts by weight of pore-forming agent and 0.1-45 parts by weight of catechol-based polymer, and adding a trihydroxymethyl aminomethane-hydrochloric acid buffer solution to obtain a slurry mixture, wherein calcium phosphate is micron calcium phosphate and / or nanometer calcium phosphate, and the catechol-based polymer is a polydopamine or dopamine graft copolymer; B, forming the slurry mixture obtained in the step A by virtue of mold pressing, pouring or 3D (Three-Dimensional) printing, and then curing the mixture for 20-30 hours in a water bath kettle at 35-40 DEG C. The bone repair material scaffold prepared by the method has good bioactivity, osteoconduction, degrading capacity and biocompatibility, and has good mechanical properties at the same time. The bone repair material scaffold can be formed by virtue of a mold pressing, pouring or 3D printing method, and can be prepared into any shape and structure.

Description

Technical field [0001] The invention relates to biomedical materials, in particular to a method for preparing micro- and nano-calcium phosphate / catechol-based polymer bone repair scaffolds Background technique [0002] Bone defect repair materials are one of the most clinically demanded biomaterials (Al-Aql ZS, et al. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res, 2008;87(2):107-118 ), and bone scaffold materials are more suitable bone repair and replacement materials. The ideal bone scaffold material needs to have the following properties: (1) good biocompatibility, biological activity and osteoconductivity; (2) degradability; (3) mechanical properties similar to bone, namely mechanical compatibility ; (4) Suitable porosity; (5) Easy processing and shaping, etc. (Wagoner Johnson AJ, et al. A review of the mechanical behavior of CaP and CaP / polymer composites for applications in bone replacement and repair. Acta ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/56
Inventor 屈树新刘宗光熊雄黄萍翁杰
Owner SOUTHWEST JIAOTONG UNIV
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