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Keywords: Diabetic nephropathy, osteoinductive factor, early diagnosis, biomarker Introduction Diabetic nephropathy (DN) is a diabetic syndrome called chronic capillaries pathological change and has become the leading cause of end stage renal diseases in diabetic patients from Asia, Europe and United States [ 1 , 2 ].
Drug-loaded microsphere-modified porous calcium phosphate cement and its preparation method and repair material
This invention relates to the field of bone repair technology, specifically to drug-loaded microsphere-modified porous calcium phosphate bone cement, its preparation method, and repair material. The solid phase of the porous calcium phosphate bone cement consists of a porous calcium phosphate bone cement matrix and drug-loaded microspheres dispersed therein. The porous calcium phosphate bone cement matrix has a three-dimensional interconnected pore structure, and the drug-loaded microspheres have a core-shell structure, with the outer shell being a biodegradable material and the core being a osteoinducing factor. This porous calcium phosphate bone cement utilizes porous CPC to provide space for bone integration, and the drug-loaded microspheres achieve long-term controlled release of the osteoinducing factor, achieving efficient bone defect repair through an integrated "bone conduction-bone induction-bone integration" process.
Owner:CHANGCHUN SINOBIOMATERIALS CO LTD