31 results about "OSTEOINDUCTIVE FACTOR" patented technology

An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-β, BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.

The present invention discloses a kind of degradable bone lacuna inside haemostatic material and preparation method thereof which belongs to biological material field. The purpose of the invention is to solve existing problem that bone wax not easily degraded and absorbed, or degradation production tend to initiate inflammation. The haemostatic material described in the invention is composed of 1-10% medical sodium alginate solution in mass concentration and medical faecula which accounts for 15-40% of mass of sodium alginate solution. Inorganic particulate, antibiotic, bone-inducing factor and haemostatic can be further added. Degradable bone lacuna inside haemostatic material can be prepared by mixing medical sodium alginate solution and medical faecula. The haemostatic material of the invention is easy degraded, the degradation production is innoxious and nonirritant to human organisms, and has good ductibility and mechanical strength.

The invention discloses a nano bone repair material with biological activity and a preparation method thereof. The nano bone repair material with biological activity has controlled release effectiveness for bone inductive factors and belongs to the technical field of biomedical materials. The bone repair material with biological activity consists of nano-hydroxyapatite/ collagen composite nHAC, biodegradable polymer material polylactic acid PLA and chitosan controlled release microspheres for treating effective quantity of bone inductive factors. By adopting the method described in the patent claim 1 of physically mixing three materials and combining the three materials by supersonic dispersion technology, the bone repair material with biological activity is compounded and prepared. The invention is a novel bone which has excellent biocompatibility and biodegradability and better bone inductive property than bone inductive property reported in technical literature reports of the prior art, and is very hopeful to be widely used in clinic as the repair material of bone defects.

The invention relates to injectable hydrogel for promoting bone regeneration and a preparation method of the injectable hydrogel, and belongs to the technical field of biomedical engineering materials. The invention provides a bioactive nano-composite hydrogel based on chitosan methacrylate and pami magnesium phosphate nano-particles. The hydrogel is used for local delivery and on-demand simultaneous release of bioactive ions and biological factors. The nano-composite hydrogel prepared by the invention has good injectability and effective stress relaxation, so that the hydrogel is easy to inject and adapts to bone defects with irregular shapes. Magnesium ions released by the hydrogel promote osteogenic differentiation of human mesenchymal stem cells (hMSCs) and activation of alkaline phosphatase (ALP). In addition, a bone induction factor BMP-2 is released to further promote osteogenic differentiation of the hMSC. Results show that the injectable nano-composite hydrogel mediates optimized release of various treatment factors, and effectively promotes in-situ bone regeneration through minimally invasive surgery.

The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g. a transgene) encoding a therapeutic osteoinductive factor to target cells in vivo enabling the cells to produce the osteoinductive factor at the site of the bone pathology. The delivery is achieved by a simplified method which does not require cumbersome ex vivo techniques or additional matrix or scaffolding agents. Such viral and non-viral delivery vehicles of the present invention are derived from the following nonlimiting examples: adenoviruses, adeno-associated viruses, retroviruses, herpes simplex viruses, liposomes, and plasmids. The osteoinductive factors include, but are not limited to, growth factors, cytokines, growth factor inhibitors and cytokine inhibitors.

The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g. a transgene) encoding a therapeutic osteoinductive factor to target cells in vivo enabling the cells to produce the osteoinductive factor at the site of the bone pathology. The delivery is achieved by a simplified method which does not require cumbersome ex vivo techniques or additional matrix or scaffolding agents. Such viral and non-viral delivery vehicles of the present invention are derived from the following nonlimiting examples: adenoviruses, adeno-associated viruses, retroviruses, herpes simplex viruses, liposomes, and plasmids. The osteoinductive factors include, but are not limited to, growth factors, cytokines, growth factor inhibitors and cytokine inhibitors.

The invention provides a biocompatible bone graft. The main components of the stent include silk fibroin, polyvinyl alcohol, calcium salt, cartilage cytoskeleton-removed component of amphibian and an osteogenic induction factor; and the mechanical strength and degradation speed of the bone graft can be controlled by changing the proportion of the components. The biocompatible bone graft is of a three-dimensional solid shape and has good mechanical properties; and dense holes in the surface promote the adhesion and regeneration of cartilage cells. In the preparation process of the biocompatible bone graft, heating is not needed, no chemical or enzyme crosslinking agent is used, and the activity of each component is maintained. The biocompatible bone graft gives play to the collaborative advantage of each component and is applied to the substitute graft of bone tissue defect.

The invention discloses a bone induction material which comprises bone induction factors and carriers; the bone induction factors comprise bone morphogenetic proteinbmp or basic fiberblast growth factors, and the carriers form gel matrix through the interaction among fibernogen, fibernectin, heparin, fiber protein stabling factor, thrombin and calcium chloride; the bone induction factor is embedded in the gel matrix. The invention further discloses a preparation method and application of bone induction material, which can release the bone morphogenetic proteinbmp slightly, efficiently and stably, and can improve the biological activity of bone morphogenetic proteinbmp.

The present invention is directed to methods, systems and reagents for providing contrast media that are compatible with osteoinductive factor induced bone formation.

The invention relates to a preparation method of a dextral hydrogel material, and solves the technical problem that an existing matrix material can hardly precisely regulate adipogenic differentiationof stem cells. The preparation method comprises mainly the following main steps: (1) dissolving a dextral gel factor in a dimethyl sulfoxide solution to obtain a dextral gel factor solution with a volumetric concentration of 12 to 33 mg/[mu]l, and placing the solution at the bottom of a 24-pore plate; (2) uniformly mixing the prepared dextral gel factor solution with a culture medium suspension of mesenchymal stem cells in the 24-pore plate, and standing still at 30 to 40 DEG C for 30 to 60 minutes to form dextral hydrogel; (3) putting the prepared dextral hydrogel into an osteoinductive factor-free culture medium suspension of mesenchymal stem cells for culturing, and replacing the culture medium of the mesenchymal stem cells on the dextral hydrogel at intervals. The preparation method can be widely applied to the field of hydrogel fibers for regulating and controlling the adipogenic differentiation of the three-dimensional mesenchymal stem cells.

A titanium and tantalum composite microsphere bone filling medical material is characterized in that the bone filling medical material is a titanium and tantalum composite microsphere, the titanium and tantalum composite microsphere comprises a microsphere core made of a titanium/tantalum two-phase composite material and a microsphere surface formed by a winding tantalum porous layer, the titanium/tantalum two-phase composite material is formed through the steps of preparing a porous microsphere by braiding medical tantalum or tantalum alloy wires, injecting a liquid titanium or titanium alloy melt into the center of the porous microsphere, cooling and solidifying, and the microsphere surface includes a space for surface bioactive coating and medicine loading. The titanium and tantalum composite microsphere bone filling medical material substantially improves the strength and rigidity of the bone filling medical material, realizes high fatigue life in biological environment, maintains excellent biocompatibility and bone conduction, provides enough space and possibility for medicine loading and loading of bone inducement factors, and is suitable for various bone filling, restoration, reconstruction and other orthopedic clinic applications under minimal invasion conditions.

An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.