Medical semi-degraded titanium-magnesium composite microsphere bone filling material

Abstract

The invention discloses a medical semi-degraded titanium-magnesium composite microsphere bone filling material which comprises titanium-magnesium composite microspheres. The titanium-magnesium composite microspheres are woven into porous microspheres by medical titanium or titanium alloy wires, wherein liquid magnesium or magnesium alloy melt liquid is injected into the centers of the porous microspheres; the titanium / magnesium two-phase composite material formed after cooling and solidifying are used for preparing microsphere cores and microsphere surfaces formed by winding type titanium porous layers; spaces for biological activity coating of the surfaces and loading of drug are formed in the surfaces of the microspheres; the magnesium in the titanium / magnesium two-phase composite material is degraded in the biological environment; the degradation rate can be regulated. By virtue of the medical semi-degraded titanium-magnesium composite microsphere bone filling material, the strength and stiffness of the bone filling material are improved; the fatigue life of the biological environment is prolonged; the excellent biocompatibility and osteoconduction are retained; the long-term stability of the implant in the biological environment can be retained by degradation of magnesium and growth of new bone; the space and the possibility of loading drugs and loading bone induction factors are also provided; the material is suitable for orthopedic clinical application for filling, repairing and rebuilding various bones in the minimally-invasive situation.

Description

technical field [0001] The invention relates to a medical bone filling material, in particular to a semi-degradable titanium-magnesium composite microsphere bone filling medical material, which belongs to the technical field of biomedical engineering. Background technique [0002] There are a large number of bone defect cases in orthopedic clinics, and bone filling and repair materials that can provide sufficient strength are needed. Although autologous bone transplantation is generally recognized as the safest and most reliable method, it will cause secondary damage to patients; The problem is also limited by the source; the bone cement used in large quantities in clinical practice has the risk of curing and exothermic damage to the surrounding body tissue, and the biomechanical properties of the cured bone cement are seriously mismatched with the natural bone, which affects the long-term stability. Therefore, new orthopedic materials with excellent bone conduction and exce...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the deficiency of low strength and rigidity of the existing human bone defect repair materials, and provide a titanium-tantalum composite microsphere bone filling medical material, which can significantly improve the strength and rigidity on the basis of maintaining excellent osteoconductivity, and Through the degradation of magnesium in the core part of the material and the ingrowth of new bone, the long-term stability of the implant in the biological environment is constructed, and a sufficient surface porous layer is provided to facilitate subsequent bioactive coatings, introduction of osteoinductive factors, loading Various functional improvements such as strontium elements, antibacterial silver ions, anti-inflammatory or anti-tumor drugs, etc., which have high strength and stiffness, long fatigue life in biological environments, and excellent bone conduction properties

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