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Ceramic matrix degradable artificial bone biomaterial for 3D printing

A biomaterial and 3D printing technology, which is applied in the field of medical artificial bone biomaterials, can solve the problems of poor clinical application effect, unstable product performance, large structure difference with human bone, etc., to save operating space and large connection diameter in the hole , good porosity

Inactive Publication Date: 2016-07-20
金马丁明
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The annual transaction volume in the domestic market is about 30 billion yuan, most of which are products of foreign multinational companies. Due to the high price, most patients in our country cannot afford it.
Although there are similar products in our country, due to the basic industry, there are differences in raw material processing, production technology and quality control, etc., the product performance is often not stable, the structure is different from human bones and there are various defects, and the clinical application effect is not good. Good, often cause medical disputes due to quality problems

Method used

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  • Ceramic matrix degradable artificial bone biomaterial for 3D printing
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Embodiment Construction

[0026] First of all, it should be noted that in the following description, these reference documents will be cited:

[0027] [1] Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science, 1999, 284(5411): 143-147.

[0028] 【2】HorwitzEM, ProckopDJ, FitzpatrickLA, etal.

[0029] 【3】JiangY, JahagirdarBN, ReinhardtRL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature, 2002, 418(6893):41-49.

[0030] 【4】TsengYH, KokkotouE, SchulzTJ, et al.

[0031] 【5】ChengH, JiangW, PhillipsFM, et al. Osteogenic activity of the fourteen types of human bonemorphogenetic proteins (BMPs).

[0032] 【6】GovenderS, CsimmaC, GenantHK, et al.

[0033] 【7】LuoJ, TangM, HuangJ, etal.TGFbeta / BMPtypeIreceptorsALK1andALK2areessentialforBMP9-inducedsteogenicsignalinginmesenchymalstemcells.JBiolChem,2010,285(38):29588-29598.

[0034] [8] Sinha KM, Zhou X. Genetic and molecular control fosterixins keletal formation. J Cell Bioc...

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Abstract

The invention discloses a ceramic matrix degradable artificial bone biomaterial for 3D printing. The biomaterial is formed by compounding a bone morphogenetic protein, tricalcium phosphate, biological ceramic and polylactic acid in percentage by weight, wherein for different age groups, the weight percentages are different. According to the preparation method, the non-wire printing is adopted, the biological ceramic and tricalcium phosphate powder are mixed uniformly, furthermore, the polylactic acid and the bone morphogenetic protein are canned in a liquid state, mixed powder enters a printer by being absorbed through a vacuum guiding pipe of the printer, the polylactic acid (PLA) and the bone morphogenetic protein (BMP) which are canned in the liquid state are fully mixed with the mixed powder to form a polymer, and then a complex artificial bone biomaterial model is printed through a printer head.

Description

technical field [0001] The invention relates to a medical artificial bone biomaterial, in particular to a ceramic-based degradable artificial bone biomaterial for 3D printing. Background technique [0002] Healthy survival is the first priority of human development. Medical health has become a great cause related to the prosperity of the country, the development of high-tech industries and the well-being of the people. Currently, the severe shortage of hard tissue bone grafts has resulted in the disability and even death of a large number of patients. Therefore, there is an urgent need to develop absorbable artificial bone scaffolds with biomimetic features in terms of material composition, microstructure, and geometry, which have become the gold standard for large-segment bone replacement. The synergistic integration of high-tech resources, venture capital, superior talent teams, and advanced management systems will create huge social and economic benefits for the everlas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/44A61L27/46A61L27/54A61L27/56A61L27/58B33Y80/00
CPCA61L27/425A61L27/427A61L27/446A61L27/46A61L27/54A61L27/56A61L27/58A61L2300/252A61L2430/02B33Y80/00C08L67/04
Inventor 金马丁明
Owner 金马丁明
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