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Degradable bone lacuna inside haemostatic material and preparation method thereof

A hemostatic material and bone cavity technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of large product influence, multiple reaction conditions, and long reaction time, and achieve simple preparation process, short degradation cycle, and preparation short cycle effect

Inactive Publication Date: 2009-06-03
BEIJING UNIV OF CHEM TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this patent is that there are many monomers involved in the preparation process and many reaction conditions, so the reaction conditions have a great influence on the composition and properties of the product, and the reaction time is long

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) adding medical sodium alginate into sterile deionized water, mechanically stirring at 40°C to prepare a 1% sodium alginate solution;

[0028] 2) Add medical corn starch accounting for 40% of the mass of the sodium alginate solution to the sodium alginate solution, stir in a Hacker internal mixer for 15 minutes at 80°C and 20t / min, and wait until the temperature drops to 30°C under static conditions , after continuing to stir mechanically at 60t / min for 20min in the Haake mixer, use Co 60 Sterilized to obtain a degradable hemostatic material in the bone cavity.

Embodiment 2

[0030] 1) adding medical sodium alginate into sterile deionized water, mechanically stirring at 80°C to prepare a 10% sodium alginate solution;

[0031] 2) Add medical cornstarch accounting for 15% of the mass of sodium alginate solution to the sodium alginate solution, stir in a Hacker mixer for 15 minutes at 60°C and 20t / min, and wait for the temperature to drop to 30°C under static conditions , after continuing to stir mechanically at 60t / min for 20min in the Haake mixer, use Co 60 Sterilized to obtain a degradable hemostatic material in the bone cavity.

Embodiment 3

[0033] 1) adding medical sodium alginate into sterile deionized water, mechanically stirring at 60°C to prepare an 8% sodium alginate solution;

[0034] 2) Add medical corn starch accounting for 30% of the mass of the sodium alginate solution to the sodium alginate solution, stir in a Hacker internal mixer for 15 minutes at 70°C and 20t / min, and wait for the temperature to drop to 30°C under static conditions , after continuing to stir mechanically at 60t / min for 20min in the Haake mixer, use Co 60 Sterilized to obtain a degradable hemostatic material in the bone cavity.

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Abstract

The present invention discloses a kind of degradable bone lacuna inside haemostatic material and preparation method thereof which belongs to biological material field. The purpose of the invention is to solve existing problem that bone wax not easily degraded and absorbed, or degradation production tend to initiate inflammation. The haemostatic material described in the invention is composed of 1-10% medical sodium alginate solution in mass concentration and medical faecula which accounts for 15-40% of mass of sodium alginate solution. Inorganic particulate, antibiotic, bone-inducing factor and haemostatic can be further added. Degradable bone lacuna inside haemostatic material can be prepared by mixing medical sodium alginate solution and medical faecula. The haemostatic material of the invention is easy degraded, the degradation production is innoxious and nonirritant to human organisms, and has good ductibility and mechanical strength.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a degradable hemostatic material in a bone cavity and a preparation method thereof. technical background [0002] Bone wax (the main component is beeswax) is widely used in hemostasis of bone sections in craniocerebral surgery, cardiac surgery, orthopedics and other operations because of its unique hardness, toughness, viscosity and mechanical barrier effect. However, its fatal flaw is that it cannot be degraded, so it will remain permanently in the human body as a foreign body, which can easily inhibit bone regeneration and cause symptoms such as bacterial infection and rejection. [0003] In order to overcome the non-degradable defect of bone wax, people try to research and develop absorbable bone wax substitutes. For example, in 1950, Geary and Frantz reported a composite material made of absorbable polyethylene glycol and oxidized cellulose. This composite mat...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/44A61L15/42A61L15/62
Inventor 石锐张立群田伟陈大福行勇刚徐小川
Owner BEIJING UNIV OF CHEM TECH
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