89 results about "Human organism" patented technology

The present invention relates to a nucleic acid molecule comprised of first and second nucleic acid elements that each bind a target molecule, and a three-way junction operably linking the first and second nucleic elements. Also disclosed is an RNA scaffold comprising first and second RNA receptor regions operably linked by a three-way junction, wherein the first and second RNA receptor regions each comprise a stem defined by at least two sets of consecutive, canonic, paired bases. A method of using a multivalent nucleic acid aptamer to bring a first and second target molecule into proximity of one another is also disclosed. Also disclosed are constructed DNA molecules, engineered genes, transgenic non-human organisms, methods of modifying activity of target molecules, and functional RNA molecules comprising an RNA scaffold and one or more functional modules. A method for modular design and construction of nucleic acid molecules is also disclosed.

The present invention discloses a kind of degradable bone lacuna inside haemostatic material and preparation method thereof which belongs to biological material field. The purpose of the invention is to solve existing problem that bone wax not easily degraded and absorbed, or degradation production tend to initiate inflammation. The haemostatic material described in the invention is composed of 1-10% medical sodium alginate solution in mass concentration and medical faecula which accounts for 15-40% of mass of sodium alginate solution. Inorganic particulate, antibiotic, bone-inducing factor and haemostatic can be further added. Degradable bone lacuna inside haemostatic material can be prepared by mixing medical sodium alginate solution and medical faecula. The haemostatic material of the invention is easy degraded, the degradation production is innoxious and nonirritant to human organisms, and has good ductibility and mechanical strength.

Positive-negative selector (PNS) vectors are provided for modifying a target DNA sequence contained in the genome of a target cell capable of homologous recombination. The vector comprises a first DNA sequence which contains at least one sequence portion which is substantially homologous to a portion of a first region of a target DNA sequence. The vector also includes a second DNA sequence containing at least one sequence portion which is substantially homologous to another portion of a second region of a target DNA sequence. A third DNA sequence is positioned between the first and second DNA sequences and encodes a positive selection marker which when expressed is functional in the target cell in which the vector is used. A fourth DNA sequence encoding a negative selection marker, also functional in the target cell, is positioned 5′ to the first or 3′ to the second DNA sequence and is substantially incapable of homologous recombination with the target DNA sequence. The invention also includes transformed cells containing at least one predetermined modification of a target DNA sequence contained in the genome of the cell. In addition, the invention includes organisms such as non-human transgenic animals and plants which contain cells having predetermined modifications of a target DNA sequence in the genome of the organism.

The invention relates to medicine and can be used for the disclosure of diseases in early stages. An object of the present invention is simplification and increase of accuracy of diagnosis of the state of human organism. According to the invention in the method of diagnosis of the human organism state consisting in obtaining visual images of structure of gas discharge streamers of fingers in electromagnetic field when contacted with electrode and in estimating streamer parameters, the visual images of structure of gas discharge streamers of fingers are divided into sectors, corresponding to various organs or systems of human organism, each sector is projected along the contour of the silhouette of human body, forming a single image at that, after which the human organism state is diagnosed by way of estimating parameters of gas discharge streamers of the obtained single image; closed curves are determined at that, corresponding to the borders of zones of contact of fingers with the electrode, cross points of these lines with the lines dividing the images of structure of gas discharge streamers of fingers into sectors are determined, and the single image is formed by these points along the silhouette of human body.

The invention relates to a skidproof nail box of a surgical linear cutting stapler, which is provided with a nail box (6), wherein the upper wall surface of the nail box is provided with a longitudinal cutting groove (62) and the two sides of the cutting groove are respectively provided with a nail outlet hole. The skidproof nail boxis characterized in that the upper wall surface of the nail box is provided with a skidproof convex-concave surface. The skidproof convex-concave surface can effectively prevent human organisms from skidding in an operation process, thereby ensuring surgical cutting and suturing quality.

This invention is in the area of regulatory DNA sequences and their methods of use. Specifically, DNA sequences found in the regulatory region of cytoprotective genes are described that are termed cytoprotective response elements. DNA constructs also are provided that include cytoprotective response elements operably linked to heterologous protein coding sequence, as well as cells and non-human organisms that include the cytoprotective response elements optionally operably linked to a heterologous protein coding sequence, and a method for screening for a compound that increases mRNA or protein regulated by a cytoprotective response element. It has been discovered that the cytoprotective response elements mediate the coordinate activation of certain genes that protect cells from damaging effects of oxidative stress, and that they do so, for example during conditions of hemodynamic shear stress.

The invention relates to an ultrasonic diagnostic instrument which comprises a front-end device and a digital signal processing device. The front-end device comprises a front-end logical control module, a transmission module, a probe array processing module and a receiving module; wherein, the transmission module comprises a high-pressure regulating sub-module and a transmission driving sub-module; and the receiving module comprises an amplification sub-module and an analog / digital conversion sub-module. The ultrasonic diagnostic instrument is characterized in that the amplification sub-module comprises at least a two-stage time-gain controlling amplifier. By adopting the transmission module with adjustable power, the ultrasonic diagnostic instrument is applied to various human organisms, and the damage to a fetus is avoided; a multistage time-gain controlling amplifier is arranged in the receiving module, so the gain range is expanded, and the brightness of the near field pattern is reduced, so as to lead the near field pattern to be clearer.

The invention discloses a safe medical needle comprising a needle tubule. A second inclined plane and a first inclined plane are positioned at the front end of the needle tubule, and the axial length L1 of the first inclined plane is shorter than the axial length L2 of the second inclined plane; the length L2 of the second inclined plane is preferably 65-75% of the total length L of the two inclined planes, and a small concave arc extending backwards is positioned at an inner point of the needle on the first inclined plane, and the inner point is adjacent to the top end of the arc line. Based on the structure of the former needle, the length L2 of the second inclined plane extends towards the first inclined plane, and a small concave arc is formed on the top end of the arc line of the inner point of the needle by fine grinding, sand blasting or laser beam heat treatment, thus the resistance against insertion of the needle head is reduced, absolute safety is ensured as human organism is not affected, needle insertion is more smooth, amount of bleeding is reduced, and pains of patients can be relieved. The medical needle is a really safe medical needle and can replace all the existing medical needles used in various situations.

The invention discloses a method for preparing donkey skin collagens. In the method, fresh donkey skin is used as a raw material, and modified donkey skin collagen products are modified by steps of unhairing, degreasing, crushing, alkali solution soaking, low-temperature enzymolysis, purification, modification and the like. The donkey skin collagen products prepared by the method is characterized by retaining a triple helical structure, possessing biological activity, being homologous and compatible with human organisms and skin, along with high biological degradability, low antigenicity and the like; and the donkey skin collagens can be diluted by water in any ratio and be used for preparing surgical implants and tissue engineering medical products and developing medicaments, medical preparations, healthcare products and the like.

The invention provides isolated nucleic acids that encode LCP, including two isoforms, and fragments thereof, vectors for propagating and expressing LCP nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel LCP isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human LCP nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human LCP gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the LCP nucleic acids, proteins, and antibodies of the present invention.

The invention relates to a reflection type pulse oximeter, which comprises an acquiring module, a processing module, a display module and a power supply module, wherein the acquiring module is used for acquiring pulse blood oxygen data, and comprises a light-emitting drive, a light-emitting tube and a light sensor; the light-emitting drive is used for driving the light-emitting tube; the light-emitting tube and the light sensor are arranged on the same side of a measured part, and an included angle with a predetermined degree is formed between the light-emitting tube and the light sensor; the light sensor acquires data by receiving reflected light of the measured part; the processing module is connected with the acquiring module, and is used for processing the pulse blood oxygen data acquired by the acquiring module; the display module is connected with the processing module, and is used for displaying information processed by the processing module to a user; and the power supply module is connected with the acquiring module, the processing module and the display module, and is used for supply power for each module under the control of the processing module. The reflection type pulse oximeter can be used for detecting the pulse blood oxygen saturation degree on a plurality of parts of a human body, does not press human organisms, and is simple in structure and convenient and quick in measurement.

The invention relates to a quantum biological resonance bed pad, which comprises a bed pad for support horizontal body. Wherein, said bed pad also comprises a quantum generator outside the bed pad, and wires connecting the bed pad and quantum generator; the bed pad has bed pad winding distributed inside whole bed pad; the bed pad has interface via which the wire is connected to the bed pad winding; the quantum generator uses low voltage, to generate impulse current, which via the winding will generate alternative magnetic field; the impulse frequency uses the 50Hz that nears the biological frequency of human cell most as the central frequency; the alternative magnetic field can effective pass human organism to take resonance with body.

A personal electromagnetic hygiene sleep system for calibrating a human to a baseline bio-electric homeostasis with the human and the environment via stimulus-responsive and performance textiles. These textiles possessing tested and theoretical benefits to the human organism such as: Harnessing the Earth's electrically negative potential via the Earth's mobile and free electrons to be an agent that assist in canceling, reducing, or pushing away electric fields from the body as well as serving to help attenuate oxidative stress and damage to the body from positively charged Reactive Oxygen Species (Free Radicals). Conference of these benefits are effected via a person being in direct or field contact with certain stimulus-responsive performance textiles and a plurality of adjacent conductive fibers for the transport of free electrons to the body from a greater electrically negative potential, an electrical ground, via the ground potential in a standard wall outlet. All superimposed upon a mattress.

A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.

The invention relates to a healthy and environment-friendly particle feed for beef cattle, and belongs to the technical field of feed formula. The particle feed is composed of the following components in percentage by weight: 20% to 30% of straw powder, 15% to 25% of soybean meal, 12% to 20% of corn, 10% to 18% of rapeseed meal, 5% to 8% of silkworm excrement, 0.1% to 0.5% of raw ginger powder, 10% to 20% of corn protein feed, 1.5% to 3% of calcium hydrogen phosphate, 2% to 4% of stone flour, 0.5% to 1% of salt, and 0.08% to 1.5% of urea. The feed is prepared according to a natural, pollution-free and environment-friendly feed formula, is rich in a plurality of natural nutrients, can improve the organism resistance and immunity of the cattle, and improves the disease resistant performance of the cattle. The beef produced by the cattle which is fed by the particle feed is healthy, environment-friendly, green, and pollution-free, is benefit for human health, has a strong anti-oxidation performance, and can strengthen the human organism immunity. The particle feed is suitable for scale farming in medium or large scale feeding farms.

The invention relates to a pharmacological composition based on biologically active substances obtained from leaves, stems and fruit of the plant Tribulus terrestris L. to be used as an agent strengthening the immune system, increasing T-cells and anti-bodies number and testosterone quantity in human organism and having a strong anti-virus and anti-inflammatory effect in the form of a medicine or as an addition to food. The pharmacological composition represents a combination of bio-active zinc, bio-active selenium and a complex of steroid saponins obtained from leaves, stems and fruit of the plant Tribulus terrestris l. and consisting of furostanols spirostanols, sapogenins, sterols, flavonoids and other biologically active substances typical of this plant.

The present invention relates to transgenic animal models. Specifically, the present invention relates to transgenic animal models for applications associated with TSPO-related normal physiology, diseases and disorders. The present invention features transgenic nonhuman animal comprising cells with at least one copy of a non-functional, endogenous TSPO gene. Also disclosed are compounds for investigating or modulating TSPO-related functions.

The use of sensory G protein-coupled receptors that recognize chemical sensants, parti-cularly those involving olfactory and taste receptors; polypeptide fragments and mutants thereof; classes of such receptors; polynucleotides encoding such receptors, fragments and mutants thereof, and representatives of receptor classes; genetic vectors including such polynucleotides; and cells and non-human organisms engineered to express such receptor complexes, fragments and mutants of an olfactory or taste receptor, and representatives of receptor classes to simulate sensory perception of odorants and tastants is described. The use of such products as a biosensor or a component thereof to detect, identify, measure, or otherwise process the event of binding between the receptor and its cognate ligand (i.e., chemical sensant) is also described. The invention has application, for example, in the design and formulation of odorant and tastant compositions.

The invention discloses a method used for producing humanized antibodies or antigen combination fragments. The method comprises following steps: antibody heavy chain variable region and light chain variable region sequences of a non-human organism specific to a certain antigen are obtained; the sequences are compared with amino acid sequences of human embryonal system antibodies; human embryonal system amino acid sequences, which possesses highest homology with the heavy chain variable region and the light chain variable region of the non-human organism, are selectively respectively; human embryonal system antibody heavy chain and light chain variable region frame libraries are constructed, and a complete frame assembly library is assembled; the frame assembly library is expressed so as to obtain humanized heavy chain variable region and light chain variable region, which are capable of combining with the antigen, by screening, and realize preparation of the humanized antibodies or the antigen combination fragments of the humanized heavy chain variable region and light chain variable region. The method is capable of avoiding dependence on antibody structure analysis in antibody engineering processes, at the same, realizing screening on antibody expression and stability, and maintaining affinity of the humanized antibodies as far as possible.

Provided is a method for producing a homozygous non-human organism from a heterozygous non-human organism, which homozygous organism can be crossed to obtain a hybrid, comprising providing a heterozygous starting organism; allowing the organism to produce SDR-0 cells through meiosis, which cells originate from second division restitution; regenerating SDR-0 organisms from the SDR-0 cells; and producing the homozygous organism from the SDR-0 organisms thus obtained. Further provided is a method for producing a hybrid, comprising crossing a first homozygous organism that is produced according to the above method with a second homozygous organism. Also provided is a homozygous non-human organism and hybrid non-human organisms obtainable by these methods. In a preferred embodiment, the organisms are plants.

The present invention provides a method of producing sclareol, said method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP). In particular, said method may be carried out in vitro or in vivo to produce sclareol, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing said nucleic acid, as well as a non-human organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention.

The invention relates to Vitamin D2 solid dispersion coated tablet and the preparation method, belonging to pharmaceutical preparation technical field. The tablet contains Vitamin D2 and pharmaceutical excipient, with Vitamin D2 as the active component. Every ten thousand tablets contain 0.3125g of Vitamin D2, 100g of PEG-6000, 2500g of starch, 2250g of phosphoric acid calcium hydrogen, 75ml of alcohol, 100g of magnesium stearate and 50g of talc. The invention has a simple preparation method, according to which Vitamin D2 is coated to produce tablets. The Vitamin D2 tablets prepared in the method has obvious treating effects and can be taken orally. The toxicity is low and the bioavailability is greatly enhanced. Besides, the tablet has the functions of sustaining, targeting, energy provision for human organism, etc.

The invention relates to the field of measurements for diagnostic purposes, in particular to measurements associated with assessing the influence of food loads on a human organism. In order to determine the glycaemic index on the basis of the results of measuring glucose concentration in a person's blood, the period of time [delta]t from the beginning of an increase in the concentration of glucosecaused by an intake of food up to reaching a maximum value of the concentration of glucose is determined and the maximum increase in the concentration of glucose in the blood [delta]G max for a specified period of time is determined. Furthermore, the glycaemic index of food is determined as a ratio of the maximum increase in the concentration of glucose in the blood [delta]G max to the maximum increase in the concentration of glucose in the blood which would enter a human organism upon the intake of pure glucose, the amount of which is equal to the amount of carbohydrates contained in the consumed food, and which is determined as a value proportional to the production of [delta]G max per [delta]t. The invention substantially simplifies the procedure of determining the glycaemic index of actual food and makes it possible, on the basis thereof, to produce simple personal devices for monitoring carbohydrate metabolism.

The invention belongs to the technical field of brewing of beer, and in particular relates to blueberry beer and a preparation method thereof. The blueberry beer is prepared from the following raw materials in percentage by weight: 40 to 50 percent of water, 15 to 25 percent of barley malt, 5 to 10 percent of wheat, 20 to 25 percent of blueberry juice, 2 to 4 percent of white sugar, 0.1 to 0.3 percent of lupulus, 0.2 to 0.4 percent of yeast, 4 to 8 percent of elderberry juice, and 0.2 to 0.5 percent of edible spices. The raw materials of the blueberry beer provided by the invention are easy to get, and the elderberry has the effects of promoting blood circulation and stopping pain, dispelling wind and promoting dampness, preventing a cold, and increasing the immunity of the organism; the blueberry has the effects of preventing aging of brain nerves, strengthening the heart, resisting cancers and softening blood vessels, and enhancing human organism immunity. The blueberry beer does not only maintain the flavor of the beer, also has a flavor of fruit juice; therefore, the fruity smell is pure, the bouquet is dense, the color of the blueberry beer is blue, a nutritional value is high, and the taste is sweet; moreover, the blueberry beer has a certain health-care effect; the preparation method of the blueberry beer is simple, and is suitable for industrial production.

The invention relates to a soft capsule containing oviductus ranae. The soft capsule comprises content matters and a capsule shell, wherein the content matters contain the following materials in percentage by mass: 10-50% of oviductus ranae meal, 3-30% of ginseng extract, and 20-80% of vegetable oil. The soft capsule is prepared from the ginseng extract and oviductus ranae meal, active ingredients in the ginseng extract and oviductus ranae meal can supplement with each other, namely can be complementary, the oviductus ranae has the effects of tonifying the kidney and nourishing the essence, and nourishing the lung and yin, and ginseng has functions of treating collapse and cardiovascular diseases as well as stomach and liver diseases, so that the soft capsule has the function of tonifying the internal organs of the body in general and is capable of enhancing the human organism immunity and prolonging the service life of the organism after being eaten.

The invention relates to the brewing and non-alcoholic industry and specifically for production of beer, low-alcohol and alcohol-free drinks The “Antioxilen” additive for beer, alcohol-free drinks contains an organic selenium compound—di-(3,4)-methyldipyrazolylselenide (DMDPS)—and also succinic acid and salts thereof (ammonium succinate or sodium succinate) as an antioxidant. The method of conditioning (enriching) drinks involves increasing biological value, improving quality and contributing antioxidant, antitoxic and hepatoprotective properties to drinks, i.e. protective properties for a human organism by adding the above additive to the finished product (drink). The additive is added in the form of a dry mixture or a solution. The invention allows for improving biological value of the product (drink), taste and useful properties thereof and also extending the “life” thereof.

The invention relates to a device with a sensor arrangement, which is able to detect magnetic or magnetized oral administration forms after oral take-up, moreover tracks the dissolution thereof via the reduction or disappearance of the magnetic field of the oral administration form, and with a log function, which records a subjective evaluation on the part of the human wearer of the sensor arrangement during or after the oral take-up.