Biocompatible bone graft and preparation method thereof

A technology of biocompatibility and bone graft, applied in the field of biocompatible bone graft and its preparation, can solve the problem of lack of ability to promote cell adhesion and regeneration, lack of cartilage regeneration ability, difficulty in applying bone graft, etc. problems, to achieve the effect of facilitating the adhesion and regeneration of bone cells, the adhesion of bone cells, and a wide range of sources

Active Publication Date: 2017-03-15
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, with the rise of research on tissue-engineered organs and cell scaffolds and the development of various biotechnologies, silk fibroin has been used more and more widely, and has been successfully used in various medical materials such as surgical sutures. However, silk fibroin Does not have the ability to promote cartilage regeneration
In additi

Method used

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  • Biocompatible bone graft and preparation method thereof
  • Biocompatible bone graft and preparation method thereof
  • Biocompatible bone graft and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of Biocompatible Bone Graft with Regenerative Performance and Elastic Strength

[0023] Preparation method 1: According to the composition of each experimental group and control group of biocompatible bone grafts in Table 1, each component was weighed, and the amphibian cartilage decellularized scaffold was crushed, and calcium salt, silk fibroin and osteogenic The inducing factor is mixed evenly, and polyvinyl alcohol ethanol solution is added, and mixed evenly to form a uniform semi-solid, which is placed in a metal mold for drying and molding to form a three-dimensional tubular bone graft with a hollow channel, and is sterilized by gamma-ray irradiation.

[0024] Preparation method 2: According to the composition of each experimental group and control group of biocompatible bone grafts in Table 1, each component was weighed, and the amphibian cartilage decellularized scaffold was crushed, mixed with calcium salt and silk fibroin, Add polyvinyl a...

Embodiment 2

[0029] Performance testing and application effect of embodiment 2 biocompatible bone graft

[0030] (1) Performance testing of bone grafts in each group

[0031] Observation of surface pore size: whether the porosity and pore size of the surface of the biocompatible bone grafts in each group were uniform under light microscope and scanning electron microscope observation.

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Abstract

The invention provides a biocompatible bone graft. The main components of the stent include silk fibroin, polyvinyl alcohol, calcium salt, cartilage cytoskeleton-removed component of amphibian and an osteogenic induction factor; and the mechanical strength and degradation speed of the bone graft can be controlled by changing the proportion of the components. The biocompatible bone graft is of a three-dimensional solid shape and has good mechanical properties; and dense holes in the surface promote the adhesion and regeneration of cartilage cells. In the preparation process of the biocompatible bone graft, heating is not needed, no chemical or enzyme crosslinking agent is used, and the activity of each component is maintained. The biocompatible bone graft gives play to the collaborative advantage of each component and is applied to the substitute graft of bone tissue defect.

Description

technical field [0001] The invention relates to the technical field of medical bone graft engineering, in particular to a biocompatible bone graft with regeneration performance and ideal mechanical strength and a preparation method thereof. Background technique [0002] The self-repair ability of bone is extremely limited, and the construction of engineered bone with tissue engineering technology provides a promising method for repairing bone defects. The research content of bone transplantation involves many aspects of materials, preparations, and transplantation medicine. The key to success is to construct an ideal biocompatible bone graft with regenerative properties and ideal mechanical strength. [0003] At present, the scaffold materials used in bone transplantation engineering include natural materials and synthetic materials. The synthetic materials mainly include polyglycolide, polylactide and their copolymers. The disadvantage of artificial synthetic materials is ...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/02A61L27/12A61L27/16A61L27/22A61L27/54A61L27/58
CPCA61L27/02A61L27/12A61L27/16A61L27/227A61L27/3608A61L27/3612A61L27/365A61L27/3683A61L27/54A61L27/58A61L2430/02A61L2300/252A61L2300/412C08L29/04
Inventor 赵应征鲁翠涛徐荷林陈翩翩诸葛德力杨靖靖许洁范子梁金冰慧沈碧欣朱群燕
Owner WENZHOU MEDICAL UNIV
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