Spinal fusion methods and devices

Abstract

Methods, devices and compositions for fusing adjacent vertebrae, and otherwise localizing bone growth, are provided. In one form of the invention, a method for fusing adjacent vertebrae includes preparing a disc space for receipt of an intervertebral disc implant in an interwertebral disc space between adjacent vertebrae, inserting the implant into the intervertebral disc space and providing an osteoinductive composition that includes an osteoinductive factor in a pharmaceutically acceptable carrier. The carrier is advantageously substantially impermeable to efflux of the osteoinductive factor and is released as the carrier is resorbed or biodegraded. Preferred carriers include a hardened, resorbable carrier, such as a calcium phosphate cement that retains at least about 50% of the osteoinductive factors greater than about 2 days. Preferred osteoinductive factors are growth factors and include bone morphogenctic proteins and LIM mineralization proteins. In alternative forms of the invention, the method may be performed without utilization of a load-bearing spinal implant by disposing the osteoinductive composition in the disc space. The method is advantageously performed on lumbar vertebrae by a posterior approach. Intervertebral fusion devices and methods for their preparation are also provided.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]The present application claims the benefit of U.S. Provisional Application Ser. No. 60 / 424,794, filed on, Oct. 24, 2000, which is hereby incorporated by reference in its entirety.BACKGROUND OF THE INVENTION[0002]The present invention relates generally to methods and devices for stabilizing the spine. More specifically, the invention provides methods and devices for fusing adjacent vertebrae and for localizing spinal bone growth.[0003]Back pain affects millions of individuals and is a common cause of disability for the middle-aged working population. A frequent cause of back pain is rupture or degeneration of intervertebral discs.[0004]Intervertebral discs, located between the endplates of adjacent vertebrae, stabilize the spine, distribute forces between vertebrae and cushion vertebral bodies. An intervertebral disc includes the nucleus pulposus, a gelatinous component that is surrounded and confined by an outer, fibrous ring, called the a...

AI Technical Summary

Benefits of technology

The patent text describes a method for reducing bone formation in undesired locations during spinal fusion procedures. This is achieved by blending osteoinductive compositions with a slow release carrier that inhibits migration of the osteoinductive composition to tissue adjacent the treatment site. The method is particularly advantageous for treatment sites that already exhibit a localized hematoma or scar tissues or exhibit a clinical predisposition for such. The invention also provides minimally invasive methods for fusing adjacent vertebrae, as well as intervertebral fusion devices that include a spinal implant and the osteoinductive compositions described above.

Problems solved by technology

Back pain affects millions of individuals and is a common cause of disability for the middle-aged working population.

A frequent cause of back pain is rupture or degeneration of intervertebral discs.

Spinal discs may be displaced or damaged due to trauma; disease, or aging.

The extruded nucleus pulposus may press on a spinal nerve, which may result in nerve damage, pain, numbness, muscle weakness and paralysis.

Intervertebral discs may also deteriorate due to the normal aging process or disease.

As a disc dehydrates and hardens, the disc space height will be reduced leading to instability of the spine, decreased mobility and pain.

Collapse of the disc space can cause instability of the spine, abnormal joint mechanics, premature development of arthritis or nerve damage, in addition to severe pain.

In certain instances, it is possible that the osteoinductive material that includes an osteoinductive factor may diffuse, or otherwise migrate, from the implant into undesired locations, which may result in bone formation in these locations.

The can be an increased risk of hematoma formation with posterior lumbar interbody fusion (PLIF) or transforamiinal lumbar interbody fusion procedure, because the blood released during these procedures can pool in the spinal canal or foramen space.

Images