The invention relates to the field of biomedical materials, in particular to
bone cement as well as a preparation method and application thereof. Comprising the steps that a component A, a component B and a component C react to form a citrate-based
prepolymer, the component A is
citric acid polyester containing at least two reactive ester-based functional groups on a terminal group or a
side chain, the component B is non-
citric acid polyester containing at least two reactive functional groups on a terminal group or a
side chain, and the functional groups are the same or different; the functional groups are selected from at least one of ester groups, hydroxyl groups, amino groups, sulfydryl groups,
epoxy groups, carboxyl groups, acid anhydrides and organic
substituent groups; the component C is
polyol; the reaction comprises an ester exchange reaction and / or a condensation
polymerization reaction and a
substitution reaction; the injectable citrate
bone cement is prepared by blending the citrate-based
prepolymer,
isocyanate and an additive, has the advantages of low curing temperature, degradability, excellent mechanical properties and osteogenesis promotion, and is suitable for orthopedics, brain
surgery and cranio-maxillofacial
plastic repair.