Absorbable metal intramedullary nail and preparation method thereof

An intramedullary nail and metal technology, applied in the field of absorbable metal intramedullary nails and their preparation in vivo, can solve problems such as accumulation of aluminum elements, pathological changes, slow discharge, toxicity, etc., so as to reduce the stress shielding effect and promote fracture healing , beneficial to bone conduction effect

Active Publication Date: 2010-04-07
CHANGSHU MICROTUBE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing animal tests on absorbable magnesium alloys are basically short-term effects within a few months, and the possibility of accumulation and pathological changes caused by aluminum elements during long-term implantation cannot be ruled out.
On the other hand, rare earth elements also accumulate in the human body and are excreted very slowly, which can also produce toxicity and cause pathological changes. For example, rare earth ions can compete for calcium ion binding sites and affect cell life activities

Method used

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  • Absorbable metal intramedullary nail and preparation method thereof
  • Absorbable metal intramedullary nail and preparation method thereof
  • Absorbable metal intramedullary nail and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A 94wt% Mg-6wt% Zn alloy ingot was melted, heat-treated at 400°C for 3 hours, and then hot-extruded into a rough billet at an extrusion temperature of 200°C. Then the lathe is processed into a linear intramedullary nail with a circular cross-sectional shape, and finally the surface of the linear intramedullary nail is modified by coating to obtain an absorbable metal intramedullary nail;

[0029] The absorbable metal intramedullary nail prepared in this example has a diameter of 5 mm and a length of 30 mm, and a hydroxyapatite coating is prepared by a thermal spraying method. The three-point bending strength is 600MPa, the tensile strength is 300MPa, and the elastic modulus is 41GPa.

Embodiment 2

[0031] Melting 99.3wt% Mg-0.7wt% Ca alloy ingot, heat treatment at 500°C for 4 hours, then hot extruding into rough bar billets, extrusion temperature is 300°C, machined into linear pith with closed clover shape in section Intramedullary nail, and then the surface of the linear intramedullary nail is modified by coating to obtain an absorbable metal intramedullary nail;

[0032] The cross-sectional shape of the absorbable metal intramedullary nail prepared in this example is as follows: figure 1 shown in . The length of the nail is 100mm, the tricalcium phosphate coating is prepared by laser cladding method, soaked in 1 liter of simulated body fluid in vitro, after a month of degradation, the weight loss rate is 30%, and X-ray diffraction (XRD) shows that there are hydroxyapatite on the surface Osteoid Ca-P salt deposition.

Embodiment 3

[0034] Melting 99wt% Mg-1wt% Mn ingot, heat treatment at 600°C for 5 hours, hot extruding into rods, extrusion temperature at 400°C, machining into linear intramedullary nail with square cross section, and then The surface is modified by coating to obtain absorbable metal intramedullary nails;

[0035] The absorbable metal intramedullary nail prepared in this example is as follows: figure 2 Shown, and the magnesium fluoride coating was prepared by hydrothermal treatment. The three-point bending strength is 600MPa. The weight loss rate is 15% after immersion in normal saline in vitro for 1 month, and the three-point bending strength is found to be above 400MPa. It is proved that certain mechanical properties can be maintained during the degradation process.

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Abstract

The invention discloses an absorbable metal intramedullary nail and a preparation method thereof, which belong to the technical field of medical appliance. The intramedullary nail is a straight nail or a radian nail and is characterized in that the intramedullary nail comprises the follow components in percentage by mass: 0.01 to 10 percent of Zn, 0.01 to 5 percent of Ca, 0.001 to 5 percent of Fe, 0.01 to 5 percent of Mn and the balance of Mg; and the outer surface of the intramedullary nail is provided with a compound coating. The elastic modulus and the density of the intramedullary nail are close to those of a human body, which avoids or reduces stress shielding effect and promotes fracture union; and simultaneously, the intramedullary nail has higher intensity so as to make up the shortage of a degradable polymeric material. The intramedullary nail can be absorbed continuously in the human body and can generate a phosphate layer of Ca and Mg during the absorption and degradation, which contributes to bone conduction. The degradation rate can be regulated effectively by changing components and a structure of alloy, and components and a structure of a coated coating.

Description

technical field [0001] The invention relates to a device in the technical field of medical devices and a preparation method thereof, in particular to a biologically safe absorbable metal intramedullary nail and a preparation method thereof. Background technique [0002] Intramedullary nailing is the implantation of a biocompatible and strong implant in the distal and proximal medullary cavities of the bone to achieve the purpose of connection and fixation of the fracture ends. Intramedullary nailing is a central axial bone nail, which is relatively stable and can greatly reduce the degree of damage to the outer periosteum and blood supply. Intramedullary nails are commonly used for straight fractures and fractures with slight curvature, and have good therapeutic effects in clinical application. [0003] Intramedullary nails currently in clinical use are mainly made of stainless steel and titanium alloys. The elastic modulus of these alloys is much higher than that of human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/86A61B17/72A61L31/02A61L31/10A61L31/08
Inventor 张绍翔李佳楠赵常利张小农
Owner CHANGSHU MICROTUBE TECH
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