Polysaccharide/calcium orthophosphate composite bone cement and preparation method thereof

Abstract

The invention discloses a polysaccharide / autosolidification calcium phosphate composite bone cement composition, which comprises the following components in percentage by weight: 10 to 95 weight percent of autosolidification calcium phosphate bone cement and 5 to 90 weight percent of polysaccharide. The bone cement composition can obtain bone cement with high strength, good toughness, strong plasticity, quick solidification, and good biocompatibility and degradability, thereby overcoming the defects of inadequate toughness and slow degradation in human bodies existing in the prior calcium phosphate bone cement materials and the defects existing in a plurality of enhancement methods in the prior art, and better meeting the requirement of operation use.

Description

technical field

[0001] The invention belongs to the field of medical biomaterials and relates to a novel organic / inorganic composite material used for filling or injecting to repair human hard tissue defects. Background technique

[0002] The repair and treatment of bone defects has long been a thorny problem for surgeons. Scientists from all over the world have been devoting themselves to the research and development of ideal bone repair materials. In the mid-1980s, Brown and Chow in the United States invented a self-curing bioactive bone defect repair material—calcium phosphate cement (Calcium phosphate cement, CPC), which can be hydrated and solidified by itself in the physiological environment of the human body. It is finally transformed into hydroxyapatite (HA) which is similar to the composition of human bone, and the heat release is less during the curing process, and it can be shaped arbitrarily according to the shape of the bone defect, which has attracted great att...