Composite bracket made of multialdehyde sodium alginate crosslinked calcium polyphosphate/chitosan and preparation and use thereof

A technology of polyaldehyde-based sodium alginate and sodium alginate, which is applied in non-active ingredients medical preparations, pharmaceutical sciences, prostheses, etc., can solve problems such as difficult tissue engineering scaffolds, and achieve good biocompatibility, good Biocompatibility and controllable degradability, the effect of improving mechanical properties

Inactive Publication Date: 2008-11-12
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Toxicity of starting materials and degradation products makes these systems difficult to use as scaffolds for tissue engi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0039] Take sodium alginate to make an aqueous solution with a mass concentration of 1%, add a sodium periodate solution with a molar ratio of 1:1 to sodium alginate and a mass concentration of 2%, and oxidize it in the dark for about 24 hours, then add it to a solution volume of 1 / 10 The ethylene glycol terminates the oxidation reaction. Add NaCl equal to the quality of sodium alginate and mix well, then add ethanol to make it precipitate. Suction filtration, dissolving the product with deionized water, precipitation with ethanol, suction filtration, repeated 3 times, and vacuum drying. Finally a white product was obtained.

[0040] The CPP is ground, sieved, and the powder with a particle size of less than 200 mesh is taken for later use. ADA (degree of oxidation: 43.7%) was dissolved in 0.1M PBS solution to prepare a solution with a mass concentration of 10%. Chitosan is dissolved in acetic acid solution to prepare a chitosan solution with a mass content of 10%. Transfe...

example 2

[0042] Take sodium alginate to make an aqueous solution with a mass concentration of 2.5%, add sodium periodate solution with a molar ratio of 1:2 to sodium alginate and a sodium periodate solution with a mass concentration of 1%, and oxidize it in the dark for about 24 hours, then add to make the solution volume 1 / 10 The ethylene glycol terminates the oxidation reaction. Add NaCl twice the mass of sodium alginate and mix well, then add ethanol to precipitate out. Suction filtration, dissolving the product with deionized water, precipitation with ethanol, suction filtration, repeated 3 times, and vacuum drying. Finally a white product was obtained.

[0043] CPP is ground, sieved, and the powder with a particle size between 200-300 mesh is taken for use. ADA (degree of oxidation: 43.7%) was dissolved in 0.1M PBS solution to prepare a solution with a mass concentration of 12%. Chitosan was dissolved in acetic acid solution to prepare a chitosan solution with a mass concentrat...

example 3

[0045] Take sodium alginate to make an aqueous solution with a mass concentration of 4%, add a sodium periodate solution with a molar ratio of 2:1 to sodium alginate and a mass concentration of 1%, and oxidize it in the dark for about 24 hours, then add it to a solution volume of 1 / 10 The ethylene glycol terminates the oxidation reaction. Add NaCl that is 1 / 2 times the mass of sodium alginate and mix thoroughly, then add ethanol to precipitate out. Suction filtration, dissolving the product with deionized water, precipitation with ethanol, suction filtration, repeated 3 times, and vacuum drying. Finally a white product was obtained.

[0046] CPP is ground, sieved, and the powder with a particle size between 200-300 mesh is taken for use. ADA (degree of oxidation: 43.7%) was dissolved in 0.2M PBS solution to prepare a solution with a mass concentration of 8%. Chitosan was dissolved in acetic acid solution to prepare a chitosan solution with a mass concentration of 5%. Trans...

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PUM

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Abstract

The invention discloses a composite frame of multi-aldehyde sodium alginate cross-linked polyethylene / chitosan for bone or cartilage repair and treatment, as well as preparation and application of the material of the framework. The framework is made from Calcium polyphosphate, chitosan and multi-aldehyde sodium alginate. As organic matrix multi-aldehyde sodium alginate cross-linked chitosan derived from nature which is the main component of the composite frameworks of the invention, therefore the composite framework is safe and non-toxic, has good biocompatibility and biodegradability, and cell identificaton signal existed on the surface provides physical support and the best chemical environment for bone or cartilage regeneration and reconstruction, the network structure makes the mechanical properties improved greatly. In addition, the components of the inorganic strengthened calcium polyphosphate are consistent with those of human bone tissue, has the property of activity which promotes bone or cartilage growth and the controllable degradation. The composite of the invention can be used as defect repair of bone or cartilage and tissue engineering, drug delivery carrier.

Description

technical field [0001] The invention relates to the technical field of bone or cartilage defect repair materials, in particular to a composite scaffold material containing inorganic / organic phases, and at the same time, the invention also relates to a preparation method and application of the composite scaffold material. Background technique [0002] Bones are the scaffolding of the human body, responsible for supporting, protecting, bearing, hematopoietic, storing calcium, and metabolizing functions. They are important tissues and organs of the human body. Clinically, bone tissue necrosis, defects and lesions are often caused by trauma, tumor, infection, congenital defects and other reasons. With the aging of the population and the increase of various traumas, the demand for biomedical materials, especially hard tissue (bone, tooth) replacement materials, continues to grow, with a large and wide range of characteristics. In 1998, the annual transaction volume of the global...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/54A61K47/34A61K47/36
Inventor 万昌秀王践云余喜讯张小华宋巍田猛陈峰李华
Owner SICHUAN UNIV
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