Dentin hypersensitivity-suppressing composition

Abstract

To provide a dentin hypersensitivity-suppressing composition enabling easy retention on a tooth surface.SOLUTION: The dentin hypersensitivity-suppressing composition comprises, based on the composition, 0.3 mass% or more and 5.0 mass% or less of aluminum lactate, 3.0 mass% or more and 6.5 mass% or less of a polymer containing a carboxyl group, and 0.05 mass% or more and 7.0 mass% or less of a chelating agent.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present disclosure relates to compositions that reduce dental hypersensitivity. [Background technology]

[0002] For example, tooth sensitivity can occur when teeth are whitened, and tooth sensitivity can also occur when teeth are whitened by the patient themselves (home whitening). A composition capable of suppressing such dentin hypersensitivity is disclosed in Patent Document 1. Patent Document 1 shows that aluminum lactate is blended with a sugar alcohol. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 10-231237 Summary of the Invention [Problem to be solved by the invention]

[0004] Such a composition for reducing tooth sensitivity must have a certain degree of viscosity (not drip-resistant) since it must be applied to the teeth and held on the tooth surface.

[0005] An object of the present disclosure is to provide a tooth hypersensitivity desensitizing composition that is easily retained on the tooth surface. [Means for solving the problem]

[0006] After extensive research, the inventors investigated thickeners to improve sagging resistance. As a result, they found that suitable sagging resistance could be achieved by adding an appropriate amount of carboxyvinyl polymer. For example, they considered adding sodium carboxymethylcellulose (CMC-Na) as another thickener, but were unable to achieve sufficient sagging resistance.

[0007] However, it was found that when a carboxyvinyl polymer is used as a thickener, lumps (so-called clumps) tend to form in the composition, making it difficult to obtain a composition with stable viscosity. The formation of clumps makes it difficult to apply the composition to the teeth, and it is also difficult to apply it evenly. In response to this, the inventors further discovered that the formation of clumps can be suppressed by creating a composition that does not contain aluminum lactate, one of the active ingredients in the composition for suppressing tooth sensitivity. Based on this, the inventors hypothesized that the presence of polyvalent metal ions (aluminum ions) during the composition manufacturing process, after the aqueous solution containing the carboxyvinyl polymer was neutralized with alkali to develop viscosity, caused the polymer to aggregate and form clumps. Based on these considerations, we thought of suppressing the occurrence of clumps without excluding aluminum lactate, since it is one of the active ingredients in the composition for suppressing tooth hypersensitivity, and we embodied this idea to complete the invention.

[0008] The present application discloses a composition for suppressing dentin hypersensitivity, which contains, relative to the composition, 0.3% by mass to 5.0% by mass of aluminum lactate, 3.0% by mass to 6.5% by mass of a polymer containing a carboxy group, and 0.05% by mass to 7.0% by mass of a chelating agent.

[0009] The polymer containing a carboxy group may be a carboxyvinyl polymer.

[0010] The chelating agent may be at least one selected from potassium citrate, sodium tripolyphosphate, and ethylenediaminetetraacetic acid. [Effects of the Invention]

[0011] According to the present disclosure, a composition containing aluminum lactate is obtained that does not form lumps and has appropriate dripping properties, and can therefore be used by users to easily and effectively suppress dentin hypersensitivity. DETAILED DESCRIPTION OF THE INVENTION

[0012] The present disclosure will be described below with reference to exemplary embodiments.

[0013] In this embodiment, the composition for desensitizing dentin is a paste-like composition and can contain the following ingredients: The composition for desensitizing dentin will be described in more detail below.

[0014] [Base material] The dentin hypersensitivity depressant composition of this embodiment contains a base material. Any base material conventionally used in dental compositions can be used as the base material. Specific examples include polyglycerins such as glycerin and diglycerin, propylene glycol, dipropylene glycol, sorbitol, xylitol, mannitol, ethylene glycol, diethylene glycol, polyethylene glycol, and monomethyl ether. Two or more of these may be used in combination. Preferably, the dentin hypersensitivity depressant composition of this embodiment contains at least one of glycerin and polyethylene glycol. The content ratio of the substrate in the dentin hypersensitivity depressant composition is adjusted appropriately depending on the materials used, but in the dentin hypersensitivity depressant composition of this embodiment, the substrate can be contained in an amount of 10% by mass or more and 80% by mass or less relative to the composition. The content of the substrate is preferably 20% by mass or more, more preferably 40% by mass or more, relative to the composition. Furthermore, the content of the substrate is preferably 70% by mass or less, more preferably 60% by mass or less. If the content of the base material is less than 10% by mass, the paste may not be able to be maintained, and if it is more than 80% by mass, the fluidity may become too high, causing problems such as dripping.

[0015] [water] In this embodiment, the dentin hypersensitivity depressant composition contains water. Preferably, it is purified water. In the dentin hypersensitivity depressant composition of this embodiment, the amount of water is preferably 10% by mass or more, more preferably 15% by mass or more, relative to the composition. On the other hand, the amount of water is preferably 40% by mass or less, more preferably 30% by mass or less, relative to the composition. If the amount of water is less than 10% by mass, dispersibility may be poor and uniformity may be difficult to achieve. If the amount of water exceeds 40% by mass, problems are unlikely to arise, but the proportions of other ingredients will be relatively low.

[0016] [Active ingredient] The composition for suppressing dentin hypersensitivity of the present disclosure contains at least aluminum lactate as an active ingredient for suppressing dentin hypersensitivity, thereby enabling effective suppression of dentin hypersensitivity. The content of aluminum lactate in the composition for suppressing dentin hypersensitivity is 0.3% by mass or more, preferably 0.4% by mass or more, and more preferably 0.5% by mass or more. If the aluminum lactate content is less than 0.3% by mass, the effect of suppressing dentin hypersensitivity may not be sufficient. On the other hand, the content of aluminum lactate in the composition for desensitizing dentin hypersensitivity is 5.0% by mass or less, preferably 3.5% by mass or less, and more preferably 2.5% by mass or less. If the aluminum lactate content exceeds 5.0% by mass, the above-mentioned clumping is likely to occur.

[0017] The active ingredient may further include materials other than aluminum lactate, such as potassium nitrate. Other materials that may be used include sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, allantoin, aluminum chlorhydrate allantoin, hinokitiol, α-bisabolol, azulene, glycyrrhetin, glycyrrhetinic acid, dipotassium glycyrrhetinate, ammonium glycyrrhetinate, and strontium chloride.

[0018] [Thickener] In this embodiment, a polymer containing a carboxy group is used as a thickener. Among these, carboxyvinyl polymer is preferred. This maintains the viscosity of the composition for suppressing dentin hypersensitivity within a predetermined range and improves sagging properties. The content of the carboxyvinyl polymer in the desensitizing composition is 3.0% by mass or more, preferably 3.5% by mass or more, and more preferably 4.0% by mass or more. If the carboxyvinyl polymer content is less than 3.0% by mass, the viscosity is low and the composition tends to drip, making it difficult to retain on the teeth. On the other hand, the content of the carboxyvinyl polymer in the composition for desensitizing teeth is 6.5% by mass or less, preferably 5.5% by mass or less, and more preferably 5.0% by mass or less. If the content of the carboxyvinyl polymer exceeds 6.0% by mass, the viscosity becomes too high, which reduces the ease of application (operability) to teeth. As mentioned above, carboxyvinyl polymer is preferred as a thickener, but any polymer containing a carboxy group can act in a similar manner, so other materials that can be used include cross-linked polyacrylates (e.g., sodium salts), alginates (e.g., sodium salts), and maleic anhydride copolymers.

[0019] [Chelate material] The dentin hypersensitivity depressant composition of this embodiment contains a chelating agent, which can prevent the dentin hypersensitivity depressant composition containing aluminum lactate and a carboxyvinyl polymer from clumping. The content of the chelating agent in the composition for suppressing dentin hypersensitivity is 0.05% by mass or more, preferably 0.1% by mass or more, and more preferably 0.2% by mass or more. If the content of the chelating agent is less than 0.05% by mass, the occurrence of clumps cannot be suppressed. On the other hand, the content of the chelating agent in the composition for suppressing dentin hypersensitivity is 7.0% by mass or less, preferably 6.0% by mass or less, and more preferably 5.0% by mass or less. If the content of the chelating agent exceeds 7.0% by mass, the effect of suppressing dentin hypersensitivity may be reduced.

[0020] The specific material of the chelating agent is not particularly limited, but examples include metaphosphoric acid, tripolyphosphate, tetrapolyphosphate, pyrophosphoric acid, hexametaphosphoric acid, sodium metaphosphate, sodium tripolyphosphate, sodium tetrapolyphosphate, sodium pyrophosphate, sodium orthophosphate, sodium hexametaphosphate, potassium metaphosphate, potassium tripolyphosphate, potassium tetrapolyphosphate, potassium pyrophosphate, potassium orthophosphate, potassium hexametaphosphate, citric acid, potassium citrate, glycine, ethylenediaminetetraacetic acid (EDTA), succinic acid, adipic acid, and salts thereof.

[0021] [pH adjuster] When the above-mentioned active ingredient aluminum lactate is contained, the dentin hypersensitivity depressant composition tends to become acidic, and to alleviate this, the dentin hypersensitivity depressant composition can contain a pH adjuster. The pH adjuster is not particularly limited and known ones can be used, but examples thereof include acidic organic compounds such as formic acid, citric acid, malic acid, lactic acid, tartaric acid, salicylic acid, trimellitic acid, benzoic acid, acetic acid, phosphoric acid, oxalic acid, maleic acid, glutaric acid, succinic acid, malonic acid, hydrochloric acid, glycerophosphoric acid, oleic acid, linoleic acid, and amino acids, and basic organic compounds such as ammonia, dimethylamine, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, calcium carbonate, magnesium carbonate, calcium carbonate, sodium bicarbonate, and potassium bicarbonate.

[0022] [others] In addition, the tooth sensitivity depressant composition of this embodiment may contain coloring agents, preservatives, sweeteners, flavorings, caries prevention materials, etc., as needed, in amounts that do not substantially adversely affect the properties and characteristics of the tooth sensitivity depressant composition.

[0023] Any coloring agent can be used as the colorant. The coloring agent can be a water-soluble coloring agent. Specific examples of coloring agents are titanium dioxide and zinc oxide. Titanium dioxide is a white powder that adds opacity to the dentifrice composition.

[0024] Any preservative can be used as the preservative, and specific examples of the preservative include ethylparaben, propylparaben, phenoxyethanol, sodium benzoate, chlorhexidine salts, isopropylmethylphenol, and cetylpyridinium chloride.

[0025] As the sweetener and flavoring agent, any sweetener and flavoring agent can be used. Specific examples of sweeteners include sucrose, sucralose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, perillartine, AMP (aspartylphenylalanine, methyl ester), sodium saccharin, and the like. Specific examples of flavoring agents include flavor oils such as oils of spearmint, peppermint (menthol), wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, and orange, and methyl salicylate. Preferably, the oral care composition of this form includes methyl salicylate.

[0026] The tooth sensitivity desensitizing composition of this embodiment can contain a material that is expected to have a caries-preventing effect, such as sodium fluoride. The material may be contained in an amount that is expected to have a caries-preventing effect, and the amount is preferably 0% by mass or more and 10% by mass or less relative to the composition.

[0027] [Effects, etc.] The dentin hypersensitivity depressant composition of the present disclosure reliably suppresses dentin hypersensitivity due to aluminum lactate, and the carboxyvinyl polymer enhances viscosity, ensuring good retention on teeth and preventing dripping. Furthermore, while the combination of aluminum lactate and carboxyvinyl polymer tends to cause clumping, the inclusion of a chelating agent can suppress clumping. Thus, the composition for suppressing tooth sensitivity of the present disclosure can simultaneously achieve suppression of tooth sensitivity, retention on teeth, and appropriate fluidity (non-formation of lumps). [Example]

[0028] The present disclosure will now be further described with reference to the following examples, although the present disclosure is not limited to these examples.

[0029] [Composition details] In Examples 1 to 8 and Comparative Examples 1 to 3, compositions for suppressing dentin hypersensitivity were prepared as shown in Table 1. Comparative Example 1 is an example in which neither a carboxyvinyl polymer nor a chelating agent was contained, Comparative Example 2 is an example in which no chelating agent was contained, and Comparative Example 3 is an example in which the amount of carboxyvinyl polymer was low.

[0030] The composition was prepared as follows: The specific materials are listed in Table 1, but are roughly as follows: Sodium fluoride, potassium nitrate, aluminum lactate, phenoxyethanol, and a chelating agent were added to distilled water and stirred to obtain a first solution. Meanwhile, a thickener was added to a mixture of glycerin and polyethylene glycol and stirred to obtain a second solution. Once the first and second solutions were homogeneous, they were mixed and stirred until homogeneous. Potassium hydroxide was then added and stirred, followed by the addition of a flavor and stirring to obtain a tooth hypersensitivity suppressant composition.

[0031] [Test method and evaluation] The compositions of each example were subjected to the following tests and evaluations, and the results are shown in Table 1. <Presence or absence of lumps> The composition of each example was visually evaluated for the presence or absence of "lumps." The evaluation was "good" when no lumps were observed, "fair" when lumps were observed but were small enough to be used as a composition for suppressing dentin hypersensitivity, and "poor" when large lumps were observed.

[0032] <Sagging> The "sagging" of each composition was measured. 0.5 ml of the composition was filled into a glass tube with an inner diameter of 10 mm and extruded onto an acrylic plate. After the surface of the acrylic plate with the composition on it was held vertically and left for 5 minutes, the length of the composition that had dripped was measured and recorded as the sagging.

[0033] <ph> The pH was measured for each example composition.

[0034] <Consistency> The "consistency" of each composition was measured. 0.5 ml of the composition was filled into a glass tube with an inner diameter of 10 mm, and the composition was extruded onto an OHP sheet (resin sheet) and crushed with a load of approximately 70 g. After 60 seconds, the diameter of the spread portion of the composition was measured, and this diameter was taken as the consistency. The diameter was the size of the most spread portion.

[0035] [Table 1]

[0036] As can be seen from Table 1, Comparative Example 1, which did not use a carboxyvinyl polymer as a thickener, had higher dripping and consistency than the Examples, making it difficult to hold on to the teeth. Also, Comparative Example 2, which used a carboxyvinyl polymer but did not use a chelating agent, produced clumps. Comparative Example 3, which contained a lower amount of carboxyvinyl polymer, had higher dripping and consistency than the Examples, making it difficult to hold on to the teeth.

[0037] The Examples showed less or no clumping compared to the Comparative Examples, and it was found that the dripping and consistency of the products made it easier to hold onto the teeth. Among them, Example 7 showed some clumping due to the small amount of chelating agent.< / ph>

Claims

1. A composition for suppressing tooth hypersensitivity, comprising: To the composition, 0.3% by mass or more and 5.0% by mass or less of aluminum lactate; A polymer containing 3.0% by mass or more and 6.5% by mass or less of a carboxy group, and 0.05% by mass or more and 7.0% by mass or less of a chelating agent, A composition for suppressing tooth hypersensitivity.

2. The composition for suppressing tooth hypersensitivity according to claim 1, wherein the polymer containing a carboxy group is a carboxyvinyl polymer.

3. 3. The composition for suppressing tooth hypersensitivity according to claim 1, wherein the chelating agent is at least one selected from potassium citrate, sodium tripolyphosphate, and ethylenediaminetetraacetic acid.

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