A dentin-sensitive mineralizing solution, its preparation method and application

Abstract

This invention relates to the field of oral care, and particularly to an anti-dentin hypersensitivity mineralizing solution, its preparation method, and its application. The anti-dentin hypersensitivity mineralizing solution provided by this invention, on the one hand, due to the ultra-small size of the ions and ion clusters in the solution and its fluidity, ensures effective diffusion into the dentinal tubules after being coated on the dentin surface; on the other hand, when the mineralizing solution comes into contact with saliva or bodily fluids, it produces a biocompatible mineral—strontium-containing calcium phosphate stable by polyphosphate—which can block exposed dentinal tubules; moreover, the introduced strontium ions can passivate the nerve conduction of external stimuli, thereby alleviating the symptoms of tooth sensitivity; polyphosphate also provides certain antibacterial properties; strontium ions and polyphosphate can jointly regulate the mineralization properties of the mineralizing solution. Therefore, the anti-dentin hypersensitivity mineralizing solution provided by this invention can effectively prevent and treat dentin hypersensitivity and other symptoms related to tooth demineralization.

Description

Technical Field

[0001] This invention relates to the field of oral care, and in particular to an anti-dentin hypersensitivity mineralizing solution, its preparation method, and its application. Background Technology

[0002] Dentin hypersensitivity (DH) refers to transient, sharp pain or discomfort that occurs when exposed dentin is stimulated by mechanical, chemical, temperature, or osmotic pressure factors, and cannot be classified as other types of dental diseases. Dentin hypersensitivity is a common oral symptom that affects a large number of people and impacts their quality of life to varying degrees. In cases of enamel erosion, gingival recession, and tooth defects, dentin can be directly exposed to the oral environment. When stimulated by heat, cold, touch, osmosis, or chemicals, the movement of fluid within the dentinal tubules generates a stimulating sensation that is transmitted to nerves, resulting in sharp pain. Therefore, the treatment of dentin hypersensitivity is generally based on two strategies: (1) desensitizing the nerve conduction of external stimuli; and (2) using dentinal tubule occlusion to seal the exposed dentinal tubules. The former uses materials primarily composed of soluble substances, but its anti-sensitivity effect is difficult to sustain. The latter uses materials primarily composed of mineralized materials, which, after application, produce a substance similar to the inorganic components of teeth—calcium phosphate—that directly seals the dentinal tubules. However, the calcium phosphate minerals produced by most mineralized materials only exist on the surface of the dentin and cannot penetrate deep into the dentin, making it difficult to maintain the sealing effect for a long time and limiting the anti-dentin hypersensitivity effect. Summary of the Invention

[0003] The purpose of this invention is to provide an anti-dentin hypersensitivity mineralizing solution, its preparation method, and its application, to solve the problems existing in the prior art. The anti-dentin hypersensitivity mineralizing solution provided by this invention, after being coated on the dentin surface, can effectively diffuse into the interior of the dentinal tubules, ultimately achieving the purpose of anti-dentin hypersensitivity.

[0004] To achieve the above objectives, the present invention provides the following solution:

[0005] This invention provides an anti-dentin hypersensitivity mineralizing solution, which includes an organic solvent, a phosphorus source, a calcium source, and a strontium source;

[0006] The concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is ≤125 mmol / L, the concentration of calcium is ≤100 mmol / L, and the concentration of strontium is ≤25 mmol / L.

[0007] Preferably, the organic solvent includes glycerol and polyethylene glycol;

[0008] The average molecular weight of the polyethylene glycol is 200-700 Da;

[0009] The volume ratio of glycerol to polyethylene glycol is (1-9):(9-1).

[0010] Preferably, the phosphorus source includes phosphate and polyphosphate; the molar ratio of the phosphate and polyphosphate is (1-50):1, based on elemental phosphorus.

[0011] The calcium source is calcium chloride and / or calcium nitrate;

[0012] The strontium source is strontium chloride and / or strontium nitrate.

[0013] Preferably, the phosphate is one or more of sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium phosphate, potassium hydrogen phosphate, potassium dihydrogen phosphate, potassium phosphate, ammonium hydrogen phosphate, ammonium dihydrogen phosphate, and ammonium phosphate; and the polyphosphate is one or more of sodium polyphosphate, potassium polyphosphate, and ammonium polyphosphate.

[0014] This invention provides a method for preparing the above-mentioned anti-dentin hypersensitivity mineralizing solution, comprising the following steps:

[0015] Mix 1 / 2 volume of organic solvent with phosphorus source and dissolve them completely to obtain a phosphorus-containing solution; the concentration of phosphorus in the phosphorus-containing solution is ≤250 mmol / L;

[0016] The remaining 1 / 2 volume of organic solvent, calcium source, and strontium source are mixed and fully dissolved to obtain a calcium and strontium-containing solution; the concentration of calcium in the calcium and strontium-containing solution is ≤200 mmol / L and the concentration of strontium is ≤50 mmol / L.

[0017] The phosphorus-containing solution is mixed with a calcium- and strontium-containing solution to obtain the dentin-sensitive mineralizing solution.

[0018] Preferably, the organic solvent includes glycerol and polyethylene glycol;

[0019] The average molecular weight of the polyethylene glycol is 200-700 Da;

[0020] The volume ratio of glycerol to polyethylene glycol is (1-9):(9-1).

[0021] Preferably, the phosphorus source includes phosphate and polyphosphate; the molar ratio of the phosphate and polyphosphate is (1-50):1, based on elemental phosphorus.

[0022] The calcium source is calcium chloride and / or calcium nitrate;

[0023] The strontium source is strontium chloride and / or strontium nitrate.

[0024] Preferably, the phosphate is one or more of sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium phosphate, potassium hydrogen phosphate, potassium dihydrogen phosphate, potassium phosphate, ammonium hydrogen phosphate, ammonium dihydrogen phosphate, and ammonium phosphate; and the polyphosphate is one or more of sodium polyphosphate, potassium polyphosphate, and ammonium polyphosphate.

[0025] This invention provides the application of the above-mentioned anti-dentin hypersensitivity mineralizing solution in the preparation of anti-dentin hypersensitivity products and / or oral remineralization products.

[0026] This invention provides an anti-dentin hypersensitivity product and / or an oral remineralization product, the active ingredient of which includes the above-mentioned anti-dentin hypersensitivity mineralizing solution.

[0027] The present invention discloses the following technical effects:

[0028] This invention proposes a biocompatible organic anti-dentin hypersensitivity mineralizing solution. This invention improves the sealing effect of mineralizing materials on dentinal tubules by combining this with the idea of ​​desensitizing nerve conduction, thereby enhancing the therapeutic effect of anti-dentin hypersensitivity. This invention uses two biocompatible organic solvents, glycerol and polyethylene glycol (average molecular weight between 200-700 Da), as solvents, with calcium and strontium ions as the main cations and phosphate and polyphosphate ions as the main anions, to prepare the organic anti-dentin hypersensitivity mineralizing solution. All reagents used have high biocompatibility. In the anti-dentin hypersensitivity mineralizing solution, the cations and anions exist as free ions, while the remainder exists as ion clusters with a size ≤5 nm. This anti-dentin hypersensitivity mineralizing solution can stably maintain its ionic and ion cluster state for more than one month in a sealed environment at ≤45℃ without producing particles with an average size >5 nm, and it does not corrode or deteriorate without the addition of corrosion inhibitors.

[0029] The anti-dentin hypersensitivity mineralizing solution prepared in this invention, on the one hand, ensures effective diffusion into the dentinal tubules after being coated on the dentin surface due to the ultra-small size of the ions and ion clusters in the solution and its fluidity; on the other hand, when the solution comes into contact with saliva or body fluids, it produces biocompatible minerals—strontium-containing calcium phosphate with polyphosphate ions—which can block exposed dentinal tubules. Furthermore, the introduced strontium ions can passivate nerve conduction of external stimuli, thus alleviating the symptoms of tooth sensitivity; the polyphosphate ions also provide certain antibacterial properties. Therefore, the anti-dentin hypersensitivity mineralizing solution provided by this invention can effectively prevent and treat dentin hypersensitivity.

[0030] The various components used in this invention do not each produce a single effect, but rather work synergistically with other components to ultimately control the state, stability, mineralization properties, and performance of the product. Because conventional materials, when applied to the tooth surface, stimulate the oral cavity to produce a large amount of saliva instantly, the material may rapidly transform into larger particles before penetrating the dentinal tubules, thus failing to penetrate deeply. However, the strontium ions and polyphosphate ions of this invention, along with polyethylene glycol, can control the morphology and phase transformation rate of the anti-dentin hypersensitivity mineralizing solution upon contact with saliva or body fluids, thereby reducing or preventing mineralization before entering the dentinal tubules. Furthermore, the polyethylene glycol used in this invention is not only a biocompatible solvent but also inhibits the aggregation of particles formed upon contact with saliva or body fluids, slowing down their size growth. All of these characteristics facilitate the penetration of the material into the dentinal tubules.

[0031] This invention also provides a method for preparing an anti-dentin hypersensitivity mineralizing solution. This method is simple and convenient, requires no additional solutions, reduces the types and amounts of raw materials used, and significantly lowers production costs. Moreover, the raw materials used in the preparation of the anti-dentin hypersensitivity mineralizing solution are water-soluble phosphates, water-soluble calcium salts, water-soluble strontium sources, and polyethylene glycol and glycerol solutions. No other toxic substances are involved. Therefore, the preparation process and the prepared product are both non-toxic.

[0032] In summary, this invention, based on the purpose of relieving tooth sensitivity, combines two approaches: sealing dentinal tubules and desensitizing nerve conduction. These two approaches are cleverly integrated into a liquid mineralization material based on an organic solvent. By stabilizing calcium and phosphorus ions and ultra-small nanoparticles, the sealing effect of dentinal tubules is significantly improved. Moreover, the introduced components have high stability. Attached Figure Description

[0033] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0034] Figure 1 The scanning electron microscope image of the dentin cross section after the anti-dentin hypersensitivity mineralizing solution prepared in Comparative Example 1 was applied to the acid-etched dentin surface.

[0035] Figure 2 The scanning electron microscope image of the dentin cross section after the anti-dentin hypersensitivity mineralizing solution prepared in Comparative Example 2 was applied to the acid-etched dentin surface.

[0036] Figure 3The image shows a scanning electron microscope (SEM) image of a dentin cross section after the dentin-sensitive mineralizing solution prepared in Example 2 was applied to the acid-etched dentin surface; where A is a SEM image of a dentin cross section at a scale bar of 10 μm, and B is a SEM image of a dentin cross section at a scale bar of 2 μm.

[0037] Figure 4 The results of stability observation of the anti-dentin hypersensitivity mineralizing solution prepared in Comparative Example 1(A) and Example 2(B);

[0038] Figure 5 This is a liquid in-situ transmission electron microscope image of the anti-dentin hypersensitivity mineralizing solution prepared in Example 2. Detailed Implementation

[0039] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0040] It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the invention. Furthermore, with respect to numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any stated value or intermediate value within a stated range, as well as each smaller range between any other stated value or intermediate value within said range, is also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0041] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0042] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be readily apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0043] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0044] Example 1: Preparation of Dentin Sensitizing Mineralizing Solution

[0045] 90 mL of glycerol was mixed with 10 mL of polyethylene glycol to obtain a mixed solvent, wherein the average molecular weight of polyethylene glycol was 200 Da.

[0046] Trisodium phosphate and sodium polyphosphate (molecular weight 1000 Da) were dissolved in a 1 / 2 mixed solvent. The amount of trisodium phosphate added made the phosphorus concentration in the mixture 240 mmol / L, and the amount of sodium polyphosphate added made the phosphorus concentration in the mixture 10 mol / L. The molar ratio of trisodium phosphate to sodium polyphosphate was 24:1 based on phosphorus content.

[0047] The remaining half of the mixed solvent was used to dissolve calcium chloride and strontium chloride, so that the concentration of calcium was 200 mmol / L and the concentration of strontium was 50 mmol / L.

[0048] The two solutions are mixed to form an anti-dentin hypersensitivity mineralizing solution, wherein the concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is 125 mol / L, the concentration of calcium is 100 mol / L, and the concentration of strontium is 25 mol / L.

[0049] Example 2: Preparation of Dentin Sensitizing Mineralizing Solution

[0050] Mix 50 mL of glycerol and 50 mL of polyethylene glycol to obtain a mixed solvent, wherein the average molecular weight of polyethylene glycol is 500 Da;

[0051] Trisodium phosphate and sodium polyphosphate (molecular weight 5000 Da) were dissolved in a 1 / 2 mixed solvent. The amount of trisodium phosphate added made the phosphorus concentration in the mixture 100 mmol / L, and the amount of sodium polyphosphate added made the phosphorus concentration in the mixture 50 mol / L. The molar ratio of trisodium phosphate to sodium polyphosphate was 2:1 based on phosphorus content.

[0052] The remaining half of the mixed solvent was used to dissolve calcium chloride and strontium chloride, so that the concentration of calcium was 120 mmol / L and the concentration of strontium was 20 mmol / L.

[0053] The two solutions are mixed to form an anti-dentin hypersensitivity mineralizing solution, wherein the concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is 75 mmol / L, the concentration of calcium is 60 mmol / L, and the concentration of strontium is 10 mmol / L.

[0054] Example 3: Preparation of Dentin Sensitizing Mineralizing Solution

[0055] 10 mL of glycerol and 90 mL of polyethylene glycol were mixed to obtain a mixed solvent, wherein the average molecular weight of polyethylene glycol was 700 Da.

[0056] Trisodium phosphate and sodium polyphosphate (molecular weight 10000 Da) were dissolved in a 1 / 2 mixed solvent. The amount of trisodium phosphate added made the phosphorus concentration in the mixture 40 mmol / L, and the amount of sodium polyphosphate added made the phosphorus concentration in the mixture 10 mol / L. The molar ratio of trisodium phosphate to sodium polyphosphate was 4:1 based on phosphorus content.

[0057] The remaining half of the mixed solvent was used to dissolve calcium chloride and strontium chloride, so that the concentration of calcium was 140 mmol / L and the concentration of strontium was 10 mmol / L.

[0058] The two solutions are mixed to form an anti-dentin hypersensitivity mineralizing solution, wherein the concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is 25 mmol / L, the concentration of calcium is 70 mmol / L, and the concentration of strontium is 5 mmol / L.

[0059] Example 4: Preparation of Dentin Sensitizing Mineralizing Solution

[0060] 90 mL of glycerol and 10 mL of polyethylene glycol were mixed to obtain a mixed solvent, wherein the average molecular weight of polyethylene glycol was 200 Da.

[0061] Trisodium phosphate and sodium polyphosphate (molecular weight 50000 Da) were dissolved in a 1 / 2 mixed solvent. The amount of trisodium phosphate added made the phosphorus concentration in the mixture 120 mmol / L, and the amount of sodium polyphosphate added made the phosphorus concentration in the mixture 100 mol / L. The molar ratio of trisodium phosphate to sodium polyphosphate was 1.2:1 based on phosphorus content.

[0062] The remaining half of the mixed solvent was used to dissolve calcium chloride and strontium chloride, so that the concentration of calcium was 40 mmol / L and the concentration of strontium was 10 mmol / L.

[0063] The two solutions are mixed to form an anti-dentin hypersensitivity mineralizing solution, wherein the concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is 110 mmol / L, the concentration of calcium is 20 mmol / L, and the concentration of strontium is 5 mmol / L.

[0064] Example 5: Preparation of Dentin Sensitizing Mineral Solution

[0065] Mix 50 mL of glycerol and 50 mL of polyethylene glycol to obtain a mixed solvent, wherein the average molecular weight of polyethylene glycol is 500 Da;

[0066] Trisodium phosphate and sodium polyphosphate (molecular weight 100,000 Da) were dissolved in a 1 / 2 mixed solvent. The amount of trisodium phosphate added made the phosphorus concentration in the mixture 140 mmol / L, and the amount of sodium polyphosphate added made the phosphorus concentration in the mixture 10 mol / L. The molar ratio of trisodium phosphate to sodium polyphosphate was 14:1 based on phosphorus content.

[0067] The remaining half of the mixed solvent was used to dissolve calcium chloride and strontium chloride, so that the concentration of calcium was 14 mmol / L and the concentration of strontium was 5 mmol / L.

[0068] The two solutions are mixed to form an anti-dentin hypersensitivity mineralizing solution, wherein the concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is 75 mmol / L, the concentration of calcium is 7 mmol / L, and the concentration of strontium is 2.5 mmol / L.

[0069] Example 6: Preparation of Dentin Sensitizing Mineral Solution

[0070] 10 mL of glycerol and 90 mL of polyethylene glycol were mixed to obtain a mixed solvent, wherein the average molecular weight of polyethylene glycol was 700 Da.

[0071] Trisodium phosphate and sodium polyphosphate (molecular weight 500,000 Da) were dissolved in a 1 / 2 mixed solvent. The amount of trisodium phosphate added made the phosphorus concentration in the mixture 30 mmol / L, and the amount of sodium polyphosphate added made the phosphorus concentration in the mixture 20 mol / L. The molar ratio of trisodium phosphate to sodium polyphosphate was 1.5:1 based on phosphorus content.

[0072] The remaining half of the mixed solvent was used to dissolve calcium chloride and strontium chloride, so that the concentration of calcium was 200 mmol / L and the concentration of strontium was 40 mmol / L.

[0073] The two solutions are mixed to form an anti-dentin hypersensitivity mineralizing solution, wherein the concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is 25 mmol / L, the concentration of calcium is 100 mmol / L, and the concentration of strontium is 20 mmol / L.

[0074] Comparative Example 1

[0075] Prepare 100 mL of glycerol solvent;

[0076] The trisodium phosphate was dissolved in 1 / 2 glycerol solvent to a concentration of 150 mmol / L. The amount of sodium polyphosphate added was such that the concentration of phosphorus in the mixture was 50 mol / L.

[0077] Dissolve calcium chloride in the remaining half of the mixed solvent to a concentration of 140 mmol / L;

[0078] The two solutions are mixed to form an anti-dentin hypersensitivity mineralizing solution, wherein the concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is 75 mmol / L and the concentration of calcium is 70 mmol / L.

[0079] Comparative Example 2

[0080] Mix 50 mL of glycerol and 50 mL of polyethylene glycol to obtain a mixed solvent, wherein the average molecular weight of polyethylene glycol is 500 Da;

[0081] Dissolve trisodium phosphate and sodium polyphosphate (molecular weight 5000 Da) in a 1 / 2 mixed solvent. The amount of trisodium phosphate added is such that the concentration of phosphorus in the mixture is 150 mmol / L. No polyphosphate is added.

[0082] The remaining half of the mixed solvent was used to dissolve calcium chloride and strontium chloride, so that the concentration of calcium was 120 mmol / L and the concentration of strontium was 20 mmol / L.

[0083] The two solutions are mixed to form an anti-dentin hypersensitivity mineralizing solution, wherein the concentration of phosphorus in the anti-dentin hypersensitivity mineralizing solution is 75 mmol / L, the concentration of calcium is 60 mmol / L, and the concentration of strontium is 10 mmol / L.

[0084] Experimental Example 1

[0085] The dentinal tubule sealing experiment was conducted on the anti-dentin hypersensitivity mineralizing solutions prepared in Example 2 and Comparative Examples 1-2. The specific steps were as follows:

[0086] A dentin slice 1 mm above the pulp chamber of the tooth crown was cut, soaked in 10% ethylenediaminetetraacetic acid solution for 5 min, then sonicated for 10 min, and washed with deionized water to obtain a dentin sample with exposed tubules.

[0087] The dentin-sensitive mineralizing solutions prepared in Example 2 and Comparative Examples 1-2 were applied to the acid-etched dentin surface, respectively. The dentin samples to be repaired were then immersed in simulated saliva and incubated in a 37°C oven for 24 hours. After rinsing under running water for 1 minute and air-drying, the samples were observed using an electron microscope. The results are as follows: Figures 1-3 As shown, the samples prepared in Comparative Examples 1 and 2 after treatment with the anti-dentin hypersensitivity mineralizing solution, although covered with a layer of mineralized material on the surface, showed no material penetration into the dentinal tubules. Figure 1 and Figure 2 However, the dentin treated with the prepared dentin-sensitive mineralizing solution produced dense mineralization on both the surface and inside, thus achieving a good sealing effect on dentinal tubules. Figure 3Meanwhile, the sealing rate was calculated based on whether the material entered the dentinal tubules. The results showed that the sealing rate after treatment in Example 2 was 90%, while the sealing rates of Comparative Examples 1 and 2 were less than 10%.

[0088] Experimental Example 2

[0089] The stability of the anti-dentin hypersensitivity mineralizing solutions prepared in Example 2 and Comparative Example 1 was observed. Specifically, the anti-dentin hypersensitivity mineralizing solutions prepared in Example 2 and Comparative Example 1 were mixed with water at a volume ratio of 1:10, allowed to stand, and the clarity, stability, and presence of precipitation were observed. The results are as follows: Figure 4 As shown, the anti-dentin hypersensitivity mineralizing solution prepared in Comparative Example 1 becomes turbid when mixed with water. After standing for 10 minutes, obvious precipitation occurs. This indicates that the anti-dentin hypersensitivity mineralizing solution prepared in Comparative Example 1 is not stable. Figure 4 In Example 2, the anti-dentin hypersensitivity mineralizing solution also forms turbidity when mixed with water. After standing for 10 minutes, no obvious precipitation occurs. This shows that the anti-dentin hypersensitivity mineralizing solution prepared in Example 2 has high stability. Figure 4 (B in the middle).

[0090] Experimental Example 3

[0091] The anti-dentin hypersensitivity mineralizing solution prepared in Example 2 was observed in situ using liquid transmission electron microscopy. The results are as follows: Figure 5 As shown, the size of the ion cluster is ≤5nm.

[0092] Experiment Example 4

[0093] The storage time and product quality of the anti-dentin hypersensitivity mineralizing solution prepared in Example 2 were investigated. The results showed that the anti-dentin hypersensitivity mineralizing solution prepared in Example 2 could stably maintain the ion and ion cluster state for more than 1 month in a sealed environment at ≤45℃ without producing particles with an average size >5nm, and it did not corrode or deteriorate without the addition of corrosion inhibitors.

[0094] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. Use of an anti-dentin sensitivity mineralizing solution for the preparation of an anti-dentin sensitivity product and / or an oral remineralization product, characterized in that, The anti-dentin sensitivity mineralization solution is composed of an organic solvent, a phosphorus source, a calcium source and a strontium source; the concentration of phosphorus element in the anti-dentin sensitivity mineralization solution is ≤125 mmol / L, the concentration of calcium element is ≤100 mmol / L, and the concentration of strontium element is ≤25 mmol / L; the organic solvent is glycerol and polyethylene glycol; the phosphorus source is phosphate and polyphosphate; the phosphate is trisodium phosphate; the polyphosphate is sodium polyphosphate; the calcium source is calcium chloride; the strontium source is strontium chloride; the average molecular weight of the polyethylene glycol is 200-700 Da; the volume ratio of the glycerol to the polyethylene glycol is 1:1; and the molar ratio of the phosphate to the polyphosphate is 2:1 in terms of phosphorus element. The preparation method of the anti-dentin sensitivity mineralization solution comprises the following steps: mixing 1 / 2 volume of the organic solvent and the phosphorus source to make them fully dissolved to obtain a phosphorus-containing solution; mixing the remaining 1 / 2 volume of the organic solvent, the calcium source and the strontium source to make them fully dissolved to obtain a calcium-and-strontium-containing solution; mixing the phosphorus-containing solution and the calcium-and-strontium-containing solution to obtain the anti-dentin sensitivity mineralization solution; the anti-dentin sensitivity mineralization solution is in the form of ions and ion clusters.

2. A dentin hypersensitivity product and / or a remineralization product of the mouth, characterized in that, The effective component comprises the anti-dentin sensitivity mineralization solution as claimed in claim 1.

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