The invention discloses a preparation method of
inositol nicotinate tablets, and belongs to the technical field of pharmaceutical preparations. By optimizing the existing process and
coating components, stable
dissolution of drugs is realized, and the method comprises the following steps: dispersing
inositol nicotinate in mixed oil to prepare an
oil phase, mixing and emulsifying the
oil phase and a water phase, performing
spray drying to obtain
drug milk
powder,
coating the
drug milk
powder with modified
chitosan, and directly tabletting the coated
drug milk
powder and auxiliary materials. The preparation method comprises the following steps: uniformly dispersing
inositol nicotinate in mixed oil to promote the
inositol nicotinate to maintain the uniformity of the
drug content in the subsequent process, and adsorbing
solid particles on the surfaces of drug-containing oil drops through an emulsification technology to protect the drug components;
coating components are reasonably designed, so that fixed-point release of the
medicine is realized, the
medicine is endowed with anti-pressure ability, and the
medicine can be directly tableted; and the coated medicine particles are mixed with auxiliary materials and then are directly tableted, so that the process is simplified, and the coating structure of the medicine particles is protected at the same time. The preparation method can prepare the
inositol nicotinate tablet with stable
drug dissolution, and the
inositol nicotinate tablet is good in taste and small in stimulation to
gastric mucosa.