System and Method for Normalized Flourescence or Bioluminescence Imaging

a bioluminescence and flourescence technology, applied in the field of medical imaging, can solve problems such as generating an un-normalized emitted light image of the tissue, and achieve the effect of improving images

Inactive Publication Date: 2008-12-18
THE GENERAL HOSPITAL CORP
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Benefits of technology

[0016]The system and method for normalized epi-illumination imaging and normalized transillumination imaging provide normalization of images generated by planar fluorescence epi-illumination imaging, by planar fluorescence transillumination imaging, by planar bioluminescence epi-illumination imaging, and by planar bioluminescence transillumination imaging. The normalization results in substantially improved images. As further described below, by using a combination of normalized epi-illumination images and normalized transillumination images, each having particular imaging characteristics, still further improvement can be achieved.

Problems solved by technology

The method further includes generating an un-normalized emitted light image of the tissue.

Method used

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  • System and Method for Normalized Flourescence or Bioluminescence Imaging

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Embodiment Construction

[0047]Before describing the imaging system and method, some introductory concepts and terminology are explained. As used herein, the term “phantom” is used to describe a test object being imaged. A phantom is typically an article having diffuse light propagation characteristics similar to living tissue, for example, a piece of appropriately engineered resin block. For another example, a phantom can be a vial, which contains cells having fluorescent proteins therein, i.e. a fluorescent marker or a fluorochrome.

[0048]As used herein, the term “excitation light” is used to describe light generated by an “excitation light source” that is incident upon a biological tissue. The excitation light can interact with the tissue, and can be received by a light detector (e.g., a camera), at the same wavelength (excitation wavelength) as that at which it was transmitted by the excitation light source. The excitation light can be monochromatic, or it can cover a broader spectrum, for example, white...

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Abstract

A system and method provide normalized fluorescence epi-illumination images and normalized fluorescence transillumination images. The normalization can be used to improve two-dimensional (planar) fluorescence epi-illumination images and two-dimensional (planar) fluorescence transillumination images. The system and method can also provide normalized bioluminescence epi-illumination images and normalized bioluminescence transillumination images. In some arrangements, the system and method can provide imagine of small animals, into-operative imaging, endoscopic imaging, and / or imaging of hollow organs.

Description

FIELD OF THE INVENTION[0001]This invention relates generally to medical imaging and, more particularly, to a system and method for generating fluorescence epi-illumination images, fluorescence transillumination images, and bioluminescence images associated with small animal imaging, intra-operative imaging, endoscopic imaging and imaging of hollow organs.BACKGROUND OF THE INVENTION[0002]Fluorescence images can be generated in-vivo for imaging of molecular functions and gene expression in live biological tissues. Fluorescence imaging of small animals has been used in biological research, including research in drug discovery and in investigation of fluorescent reporter technologies. Fluorescence imaging has also been used to study various human tissues, for example, tissues exhibiting epithelial diseases, the human breast, joints, and human teeth.[0003]Conventionally, fluorescent light has been used for high-resolution imaging of histological slices of biological tissue using so-calle...

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B6/00
CPCA61B1/00009A61B1/043A61B5/0064A61B5/0071A61B5/0084A61B5/0088A61B5/415A61B5/418A61B1/000094A61B1/000095
Inventor NTZIACHRISTOS, VASILIS
Owner THE GENERAL HOSPITAL CORP
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