The invention discloses an urban domestic sludge treatment process.The process includes the following steps of 1 preparation of dewatered sludge, wherein sludge which is concentrated and dewatered by an urban sewage treatment plant is adopted; 2, conditioning of sludge, the dewatered sludge is conveyed to a slurry regulating pool, a chemical conditioning agent is added, and the mixture is stirred and mixed to be uniform through a stirrer in the regulating pool; 3, slurry radiation treatment, wherein slurry obtained after chemical conditioning is conveyed to a radiation workshop through a conveyor belt for radiation treatment; 4, slurry low-temperature pyrohydrolysis; slurry obtained after radiation treatment is beaten into a reaction kettle through a slurry conveying pump, a reaction kettle keeps closed in the work period, after slurry enters the reaction kettle, the temperature is raised continuously in the continuous stirring process, when the temperature is raised to 85-95 DEG C, timing is started, and the temperature is maintained at 90 +/-5 DEG C for 30-35 minutes; 5, slurry obtained after low-temperature pyrohydrolysis can be directly dewatered through a membrane filter press, the moisture content is lowered to 60% or below, the number of fecal coliform groups is smaller than or equal to 100/g (mL), the slurry obtained after low-temperature pyrohydrolysis can also be combined with anaerobic digestion which has been developed and matured for stabilizing treatment, and methane gas utilization is achieved.