Chinese patent medicament for treating reflux esophagitis and preparation method thereof

A technology for reflux esophagitis and Chinese patent medicine, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc. Novel dosage form, excellent efficiency and long-lasting effect

Inactive Publication Date: 2010-11-03
THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is that the existing western medicines for treating reflux esophagitis have large toxic and side effects; the tech...

Method used

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  • Chinese patent medicament for treating reflux esophagitis and preparation method thereof
  • Chinese patent medicament for treating reflux esophagitis and preparation method thereof
  • Chinese patent medicament for treating reflux esophagitis and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0058] 1. The Chinese patent medicine for the treatment of reflux esophagitis of the present invention is a medicament made from raw materials in the following weight ratio: 10-25 parts by weight of Rubescens, 20-30 parts by weight of fried trifoliate, 6 parts by weight of licorice 15 parts by weight.

[0059] 2. The preparation method of the Chinese patent medicine for the treatment of reflux esophagitis of the present invention is carried out according to the following steps:

[0060] (1) First take 10-25 parts by weight of Rubescens, and extract 3 times with 80-90% ethanol at reflux. Each time the weight of adding 80-90% ethanol is 6-8 times the weight of Rubescens, and each extraction is 0.8~ After 1.5 hours, the reflux liquid was combined and filtered to obtain filtrate I.

[0061] (2) Combine 6-15 parts by weight of licorice, 20-30 parts by weight of fried citrus aurantium, and Dongling herbal dregs extracted with 80-90% ethanol, add water and decoc 3 times, each time adding w...

Embodiment 2

[0064] 1. The Chinese patent medicine for the treatment of reflux esophagitis of the present invention is a medicament made from raw materials with the following weight ratios: 10 g of rubescens, 28 g of fried citrus fruit, and 8 g of licorice.

[0065] 2. The preparation method of Chinese patent medicine for the treatment of reflux esophagitis is carried out according to the following steps:

[0066] (1) First take 10g of Rubescens vulgaris and extract 3 times with 80% ethanol at reflux. Each time the weight of 80% ethanol is 60g (6 times the weight of Rubescens vulgaris), extract for 0.8 hours each time, combine the reflux solution and filter, Obtain filtrate Ⅰ.

[0067] (2) Combine 8g of licorice, 28g of fried citrus aurantium and Dongling herbal residue extracted with 80% ethanol, add water and decoc 3 times, each time adding water weighs 360g (10 times the total weight of the above three herbs) , Decoction for 2.5 hours each time, combine the decoction, filter, and concentrate ...

Embodiment 3

[0070] 1. The Chinese patent medicine for the treatment of reflux esophagitis of the present invention is a medicament made from raw materials with the following weight ratios: 15 g of rubescens, 23 g of fried citrus fruit, and 10 g of licorice.

[0071] 2. The preparation method of Chinese patent medicine for the treatment of reflux esophagitis is carried out according to the following steps:

[0072] (1) First take 15g of Rubescens and extract 3 times with 85% ethanol under reflux, add 105g of 85% ethanol each time (7 times the weight of Rubescens), extract 1 hour each time, combine the reflux liquid, filter, Obtain filtrate Ⅰ.

[0073] (2) Combine 10g of licorice, 23g of fried citrus fruit, and Dongling herb residue extracted with 85% ethanol, add water to decocting 3 times, each time adding water weighs 576g (12 times the total weight of the above three herbs) , Decoction for 2.2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure ...

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Abstract

The invention relates to a Chinese patent medicament for treating reflux esophagitis and a preparation method thereof, and belongs to the field of Chinese medicinal preparations. The Chinese patent medicament is prepared from the following raw materials in part by weight: 10 to 25 parts of rabdosia rubescens, 20 to 30 parts of stir-fried immature bitter orange and 6 to 15 parts of liquorice root. The Chinese patent medicament is a pure Chinese medicinal preparation and is a novel gel oral administration preparation, can be adhered to esophageal mucosa for a long time after oral administration to play a role in local treatment, can avoid the first pass effect caused by oral administration, has the advantages of high medicament carrying rate, strong wall-hanging properties, continuous and complete absorption of medicaments, lasting medicinal effect and quick response, and can be adhered to the esophageal mucosa for a long time after the oral administration to play a role in local inflammation resistance.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and specifically relates to a Chinese patent medicine for treating reflux esophagitis and a preparation method thereof. Background technique [0002] Reflux esophagitis refers to the inflammation, erosion, ulcer and fibrosis of the esophageal mucosa caused by the reflux of the contents of the stomach and / or duodenum into the esophagus. It belongs to gastroesophageal reflux disease; it is a common disease , Frequently-occurring diseases, related to smoking, drinking, diet and mood. At present, there are not many Chinese and Western medicines used to treat reflux esophagitis on the market. Western medicines generally take a long time, and symptoms are prone to relapse after stopping the medicine, and they are expensive and have relatively large side effects. Ranitidine is currently a commonly used western medicine for the treatment of reflux esophagitis, but due to its strong si...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P1/04
Inventor 魏明宰军华段晓颖魏群段飞杨霄张建民
Owner THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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