Kit for staining esophageal mucosa

A technology of esophageal mucosa and kit, applied in the field of kits for esophageal mucosa staining, which can solve the problems of iodine stimulation, erosion, discomfort, etc.

Inactive Publication Date: 2020-06-30
金多晨
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, iodine can irritate and erode the lining of the upper GI tract, leading to adverse events including retrosternal pain and discomfort
In most medical centers, endoscopists use saline only to irrigate iodine-stained mucosa to relieve subsequent discomfort, and saline irrigation relieves mucosal irritation only to a certain extent

Method used

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  • Kit for staining esophageal mucosa
  • Kit for staining esophageal mucosa
  • Kit for staining esophageal mucosa

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Embodiment Construction

[0014] Technical thinking of the present invention:

[0015] Compound iodine solution is a mixture of elemental iodine and potassium iodide dissolved in distilled water, wherein each mL of compound iodine solution contains 0.02g elemental iodine and 0.04g potassium iodide. Therefore, the elemental iodine content of the solution is 2%, and the iodine concentration is 60 mg / mL. The elemental iodine in the compound iodine solution can stain the glycogen in the normal esophageal squamous epithelial cells into brown, while the glycogen in the epithelial cells in inflammation, squamous dysplasia and even cancerous areas is consumed or even exhausted. Light staining or even no staining after exposure to iodine solution. The significant color difference between the normal area and the lesion area can be easily detected by the endoscopist, so that the mucosal tissue can be taken from the lightly stained or non-stained area for pathological biopsy, and the detection rate of esophageal ...

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Abstract

The invention relates to a kit for staining esophageal mucosa. A staining solution used in esophageal mucosa staining by the kit is a compound iodine solution, and a neutralizing solution is a vitaminC solution. The staining solution is 20mL of the compound iodine solution and consists of iodine, potassium iodide and distilled water, wherein each milliliter of the compound iodine solution contains 0.02g iodine and 0.04g potassium iodide, the iodine content of the compound iodine solution is 2%, and the concentration of iodine is 60mg/mL. The neutralizing solution is 20mL of the vitamin C solution, wherein the vitamin C content is 2%. The invention overcomes the defect that iodine can stimulate and erode mucosa of upper digestive tracts. According to the invention, the standardization kitset comprising the compound iodine solution staining solution and vitamin C solution neutralization solution is convenient to use, can neutralize iodine staining in time, relieves discomfort symptomsof patients after iodine staining in time, and improves compliance of the patients, so that the detection rate of esophageal squamous dysplasia and canceration is greatly increased.

Description

technical field [0001] The invention relates to an esophageal mucosa staining kit set related to screening and monitoring esophageal mucosa squamous dysplasia and canceration, in particular to a kit for esophageal mucosa staining. Background technique [0002] Esophageal cancer was the sixth leading cause of cancer-related death in the world in 2012. The 5-year survival rate and postoperative 5-year survival rate of esophageal cancer were as low as 10% and 15-40%, respectively. Fortunately, early diagnosis of esophageal cancer can increase the 5-year survival rate to 85%. To date, white-light endoscopy and biopsy remain the routine methods for detecting esophageal squamous dysplasia and cancer. In addition, spraying the esophageal mucosa with compound iodine solution can increase the sensitivity of detecting esophageal dysplasia and cancer to 91-100%. Staining of esophageal mucosa with compound iodine solution has been widely used to screen for squamous dysplasia and cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/006
Inventor 张国新金多晨叶峰许迎红
Owner 金多晨
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