Method for preparing betaine hydrochloride

Abstract

The invention belongs to the technical field of feed additive and relates to a method for preparing betaine hydrochloride, which comprises the following steps: a, adding ethyl chloroacetate and methanol or isopropanol into the reactor, stirring uniformly and cooling the mixture; b, introducing trimethylamine anhydrous gas into the mixture, fully stirring after the trimethylamine anhydrous gas is introduced completely, filtering, recrystallizing collected solid product, drying under vacuum and obtaining 2-ethoxy-2-oxa-N,N,N-trimethyl-ethylammonium chloride; and c, adding 2-ethoxy-2-oxa-N,N,N-trimethyl-ethylammonium chloride and diluted hydrochloric acid into the reactor to obtain mixed solution, heating, reacting with stirring, distilling after reaction, filtering, drying collected solid product under vacuum, and thus, obtaining the refined betaine hydrochloride. In the invention, the reactions in the steps are normal operation, the safety of production is ensured, the need of using expensive raw material is obviated, the production cost is reduced, the final product does not contain sodium chloride, and the requirements of some special fields are met.

Description

technical field [0001] The invention belongs to the field of feed additives, in particular to a method for preparing betaine hydrochloride. Background technique [0002] In the development of the modern breeding industry, in order for the raised livestock and poultry to grow healthily during the growth period and have better quality after mature slaughter, in addition to the necessary staple food, some functional functions should be added during the feeding process. The auxiliary materials, that is, additives, these additives can effectively improve the quality of the cultured meat. [0003] In recent years, more and more attention has been paid to the application of betaine in the livestock and poultry industry. Because betaine can provide active methyl groups in the metabolism of biological organisms, form methyltransferases with cysteine, and participate in methylation reactions, so it is called "life methylating agent". [0004] At present, there are three main prepara...

AI Technical Summary

Problems solved by technology

[0004] At present, there are three main preparation methods of betaine, one is prepared by reacting glycine and diazomethane (Chemische Berichte, 83, 420-431, 1950), However, since diazomethane is a gas at room temperature, and is explosive, flammable, highly toxic and highly irritating, special conditions are required for transportation, storage and use, and there are likely to be potential safety hazards

The second method is prepared by reacting trimethylamine and chloroacetic acid (US 5696287). This method is a production method commonly used in China at present, but the betaine prepared by this method contains a small amount of sodium chloride, which cannot satisfy some requirements. Fields with special requirements on salt content

The third method is to use choline as raw material (WO 2001040818), and obtain betaine with oxygen oxidation under the catalysis of noble metals (such as Pt), but this method uses noble metals, and the use of oxygen also requires special conditions, so the cost is relatively high. High, not conducive to mass production