70 results about "Amine synthesis" patented technology

The invention relates to the technical field of pretilachlor synthesis, in particular to a process for synthesizing pretilachlor through continuous acylation, which at least comprises the following steps: conveying 2, 6-diethyl anilino propyl ether and chloroacetyl chloride into a microchannel reactor for reaction to generate a pretilachlor mixture; the pretilachlor product is prepared by sequentially carrying out flash evaporation treatment, high-temperature treatment, alkali washing treatment and dehydration on the pretilachlor mixture, and compared with a traditional production process, the process flow is simple, and efficient and environment-friendly continuous production of pretilachlor is realized.

The invention discloses a reductive aminase mutant and application of the reductive aminase mutant in synthesis of chiral alkylated benzyl propylamine. The invention relates to a mutant protein of carbonyl reductase, which is characterized in that the mutant protein has one or more alternative mutations in sites 85, 87, 128, 134, 162, 197, 219, 234 and 235 on the basis of an amino acid sequence as shown in SEQ ID NO: 1. On the basis of analysis of the crystal structure of reductive aminase M5 in the early stage, stereoselective transformation is carried out through site-specific mutagenesis, combinatorial mutation and the like, an efficient mutant for synthesizing an alkylated benzyl propylamine S-enantiomer is obtained, and a series of chiral amines with the selectivity larger than 99% S are synthesized with different amine donors such as benzyl acetone and benzylamine as substrates. And the method has important significance on industrial green synthesis of the chiral amine.

The invention relates to a nucleic acid molecule for preparing indigoidine, an expression vector and a recombinant engineering strain. The nucleic acid molecule comprises a sequence as shown in SEQ ID NO.2 or a nucleotide sequence which has at least 98% sequence identity with the SEQ ID NO.2. According to the present invention, the Wlpl protein encoded by the nucleic acid molecule is derived from Williamsiapylosphaerae bacteria, the amino acid sequence of the Wlpl protein is represented by SEQ ID NO.1, the protein has excellent 4 '-phosphoric acid pantetheine transferase catalytic activity, and when the Wlpl protein is used for catalyzing the synthesis process of glutamine to synthesize the indigoidine, the yield of the indigoidine can achieve 14.26 g / L, such that the indigoidine yield is substantially improved, and the good industrialization prospect is provided;

The present invention provides a catalyst, a preparation method thereof, and an application thereof in the liquid-phase alkylation of benzene and cyclohexene to synthesize cyclohexylbenzene. The catalyst uses MWW molecular sieve synthesized from inexpensive and low-toxic cyclohexylamine as the active component and silica as the binder. The prepared catalyst exhibits excellent catalytic performance in the liquid-phase alkylation reaction of benzene and cyclohexene.

The present application discloses a molecular sieve, a preparation method thereof, and an application thereof in the liquid-phase alkylation reaction of benzene and cyclohexene. It at least includes the following steps: mixing raw materials containing a silicon source and an aluminum source with cyclohexylamine and water, crystallizing and calcining to obtain the molecular sieve. The MWW molecular sieve is synthesized by using cheap and low-toxic cyclohexylamine instead of highly toxic hexamethylenimine, making the synthesis process more green. The MWW molecular sieve synthesized by cyclohexylamine exhibits more excellent catalytic performance. The template agent can be removed during low-temperature calcination.

The application relates to the field of catalytic synthesis, and discloses a methylamine synthesis method, which comprises the following steps: reacting methanol and ammonia in the presence of a zeolite catalyst treated by an organic alkali to generate a methylamine-containing stream; the acid amount of the zeolite catalyst treated by the organic alkali is 200-400 mu mol.g ‑1 The methylamine synthesis method can reduce the selectivity of trimethylamine in the reaction product, reduce the content of trimethylamine in the product, and ensure high methanol conversion rate.

This invention discloses a continuous synthesis apparatus and process for chloroamines, belonging to the field of organic synthesis technology. The continuous synthesis apparatus for chloroamines includes, in series, an acetamide sodium salt reactor, an allylamide reactor, a chloroamine synthesis reactor, and an automatic phase separator. The lower liquid outlet of the automatic phase separator is connected to a solvent removal tower, and the upper liquid outlet is connected to a dealcoholization tower. A condenser and an alcohol receiving tank are connected in series at the top of the dealcoholization tower, and the bottom of the dealcoholization tower is connected to an alkalization reactor, an automatic phase separator, and a product distillation tower. This invention also discloses a continuous synthesis process for chloroamines. The equipment of this invention can accurately monitor the reaction, shorten the reaction time, significantly improve product yield and output, and ensure stable product quality.

The invention belongs to the technical field of disease and pest control, discloses application of tyrosine hydroxylase as a target spot in prodenia litura pest control for the first time, screens out a dopamine synthesis inhibitor AMPT aiming at tyrosine hydroxylase, and develops a technology for efficiently controlling prodenia litura. According to the technology, AMPT is injected into the fourth-instar larvae of the prodenia litura, and the melanin deposition of the exoskeleton of the larvae is reduced, the color of the body surface becomes light and the athletic ability is remarkably reduced by utilizing the dopamine synthesis inhibition function of AMPT. On one hand, reduction of melanin deposition weakens the environmental adaptability of pests, and the exposure risk of the pests in the natural environment is increased; on the other hand, the migration behavior of the pests is directly influenced by the decline of the exercise ability, and the population diffusion and hazard range of the pests are limited. The dual-action mechanism reduces the environmental adaptability and survival competitiveness of the pests, and provides a new strategy for green prevention and control.

The present application relates to the technical field of compound synthesis, and in particular to a preparation method of amino acid-based lactam, comprising: A) reacting an alpha-amino acid and an alpha-hydroxy acid ester in a first solvent under the action of a first catalyst to obtain N-(hydroxyacyl)-amino acid ester; B) reacting the N-(hydroxyacyl)-amino acid ester in a second solvent under the action of a second catalyst to obtain amino acid-based lactam with a structure shown in Formula I; in Formula I, R1 and R2 are independently selected from one of hydrogen, a C1-C4 straight-chain or branched-chain aliphatic hydrocarbon group, a substituted or unsubstituted C6-C30 aryl group, a protected amino group, a protected carboxyl group, a protected hydroxyl group and a protected sulfydryl group; and the protecting group is one of an alkoxycarbonyl group, an acyl group and an alkyl group. The present application can solve the problems in the existing lactam synthesis process, such as high raw material risk, complicated process, and difficult product purification.

A method for the catalytic reduction of amides to amines belongs to the field of amine synthesis. The method involves the direct catalytic reduction of tertiary and secondary amides to amines using reagents such as iridium and silanes. The steps are as follows: In an organic solvent, the amide and silane are reacted under the catalysis of an iridium complex and an acid, followed by concentration and purification to obtain the amine. The molar ratio of amide:iridium complex:acid:silane is 1:0.0000001–0.001:0.1–1:2–4. This invention uses stable and readily available amides as raw materials and achieves high-efficiency synthesis of amines with very low catalyst loading, using an iridium complex and a low-valence acid. The steps of this invention are simple to operate and separate, the reaction rate is fast, the reaction conditions are mild, and the reagents used are all inexpensive and readily available commercial reagents. The yield is high, and the functional group tolerance is good.

The invention discloses polyimine and polyamine containing an alkyl main chain and a preparation method of the polyimine and the polyamine, and belongs to the technical field of synthesis of high polymer materials. The preparation method comprises the following steps: firstly, reacting N, N '-diboryl diamine generated after boronizing alkyl diamine with organic dialdehyde under proper conditions to synthesize polyimine containing an alkyl main chain; and secondly, carrying out hydrogenation reduction reaction on the polyimine containing the alkyl main chain prepared in the first step under proper conditions to obtain polyamine. The method is used for solving the technical problems that an existing polyamine synthesis technology is limited by toxic monomers (such as ethyleneimine) and an alkyl-containing main chain structure cannot be synthesized by a traditional process, so that industrialization is difficult and varieties are scarce.

The invention relates to a synthesis method of 2-nitro-N-[2-(2-nitrophenoxy) ethyl] aniline. The synthesis method comprises the following steps: weighing raw materials including o-nitrochlorobenzene, ethanolamine and potassium carbonate and a solvent N, N-dimethylformamide; the preparation method comprises the following steps: respectively adding o-nitrochlorobenzene, ethanolamine, potassium carbonate and a solvent N, N-dimethylformamide into a three-neck flask, and heating and refluxing; and cooling the reactant, pouring the reactant into water while stirring, carrying out suction filtration, and drying to obtain the product 2-nitro-N-[2-(2-nitrophenoxy) ethyl] aniline. The 2-nitro-N-[2-(2-nitrophenoxy) ethyl] aniline has the advantages that the 2-nitro-N-[2-(2-nitrophenoxy) ethyl] aniline is directly synthesized in one step by taking o-nitrochlorobenzene and ethanolamine as raw materials and potassium carbonate as alkali, the synthesis steps are simple, the yield is higher, and the 2-nitro-N-[2-(2-nitrophenoxy) ethyl] aniline can be used as a new material intermediate and is applied to the fields of special spandex and polyurethane.

The utility model discloses a methylamine synthesis reaction heat exchanger, which is characterized in that fixed partition plates are respectively arranged in an upper seal head and a lower seal head, and a plurality of groups of openings are formed in the fixed partition plates; a plurality of groups of inner tubes are vertically distributed in the shell, tube plates are respectively welded at the upper ends and the lower ends of the inner tubes, cavities are formed in the tube plates, and the cavities are respectively communicated with the inner tubes and the openings; the outer part of the inner pipe is coated with an outer pipe, and the end parts of the adjacent outer pipes are communicated through a connecting pipe. According to the device disclosed by the utility model, high-temperature reaction synthesis gas can be utilized to heat a mixture raw material to the greatest extent, energy recycling is fully realized, and meanwhile, reasonable cooling of the reaction synthesis gas can be realized, so that by arranging the heat exchanger, not only is the temperature of the mixture raw material increased, but also the effective cooling of the synthesis reactor is realized; and heat can be recycled, so that multiple purposes are achieved.

The invention discloses a continuous mixing and batching system for methylamine synthesis, and relates to the technical field of methylamine synthesis, the continuous mixing and batching system comprises a methanol storage tank, a liquid ammonia storage tank, an azeotrope storage tank, a mixed amine storage tank and a mixing kettle, the methanol storage tank, the liquid ammonia storage tank, the azeotrope storage tank and the mixed amine storage tank are connected with the mixing kettle through pipelines, a low-temperature heat exchanger, a start vaporizer, a three-stage high-temperature heat exchanger, a reactor, a rectifying tower and a tail gas absorption tower are arranged at the rear section of the mixing kettle. According to the invention, all component materials firstly enter the feeding premixer through the feeding pipeline, and the atomization nozzle, located at one end of the feeding premixer, of the feeding pipeline atomizes the materials and then impacts and mixes the materials, so that an efficient premixing effect is achieved. When the first stirring mixer located on the outer side of the stirring shaft and located in the feeding premixer rotates along with the stirring shaft, the stirring resistance can be reduced, and the material mixing uniformity can be further improved through impact and mesh dispersion.

Provided are a transaminase and a variant thereof, and the use of the transaminase and the variant thereof in amine synthesis.

The invention provides a supported nickel phosphide catalyst as well as a preparation method and application thereof in reductive amination reaction, and relates to the technical field of secondary amine synthesis. The preparation method provided by the invention comprises the following steps: dispersing a composite phosphoric acid carrier in a nickel solution, adding a phosphate solution, carrying out hydrothermal reaction, separating and calcining to obtain a precursor; reducing the precursor in a hydrogen-containing atmosphere to prepare the supported nickel phosphide catalyst; the metal element in the composite phosphoric acid carrier comprises one of cerium and aluminum. According to the method, nickel phosphide can be used for replacing a traditional noble metal catalyst, the catalytic reaction cost is effectively reduced, dependence on noble metal resources is reduced, and conversion of generating bicyclic secondary amine through reductive amination is facilitated.

A modified molecular sieve and a preparation method therefor, a catalyst and the use thereof, and a method for synthesizing diphenylamine from aniline. The modified molecular sieve comprises a β molecular sieve and an auxiliary component, and the auxiliary component is selected from at least one alkali metal. The indicative constant k of the modified molecular sieve is not less than 100. The catalyst prepared from the modified molecular sieve has a relatively high diphenylamine selectivity and a longer one-way operation period.

The application discloses a linear drainage ditch for rural areas and a permeation testing method thereof, relates to the technical field of sewage collection, and solves the problems of high use cost and easy damage of the existing concrete drainage ditch for rural areas, reduces the material consumption, and reduces the construction difficulty, and the specific scheme is as follows: the drainage ditch main body is provided with a grid on the groove, the drainage ditch main body is made of a mixed material, the main agent of the mixed material is epoxy resin, the curing agent is modified amine T31 synthesized by phenol, formaldehyde and fatty amine, the diluent is acetone, the toughening agent is dibutyl phthalate, the filler is fly ash, and the aggregate is fine aggregate produced by using construction waste.

This application relates to the field of catalyst technology, and more specifically, to a method for preparing a composite catalyst for the synthesis of piperoethylamine, an intermediate of berberine. The method for preparing the composite catalyst for the synthesis of piperoethylamine, an intermediate of berberine, includes the following steps: 1) mixing a nickel source and a cerium source uniformly in water, then adding aminotrimethylenephosphonic acid and mixing uniformly to obtain a mixed solution; 2) mixing the mixed solution obtained in step 1), a PVA solution, and SBA-15 powder uniformly, impregnating, and freeze-drying to obtain a lyophilized powder; 3) heating the lyophilized powder obtained in step 2) to 400-500℃ in a nitrogen atmosphere, calcining for 3-5 hours, cooling to 30-60℃; then heating to 530-700℃ in a reducing atmosphere and holding for 2-3 hours, followed by cooling to obtain the final product. The composite catalyst prepared in this application can significantly improve the conversion rate of piperoacetonitrile and the selectivity of piperoethylamine.

The invention discloses a method for photocatalytic synthesis of polydeuterium substituted amine, and relates to the technical field of chemical synthesis. The method comprises the step of reacting a carbonyl compound with an amine compound in the presence of a deuterium-containing reagent, a mercaptan catalyst and a reducing agent under the conditions of a photocatalyst and illumination to obtain the polydeuterium substituted amine. According to the method disclosed by the invention, multiple introduction of deuterium atoms at alpha-carbon sites of a target amine product is realized through a series free radical mechanism initiated by photon-generated carriers, so that simple and easily available raw materials are directly converted into the polydeuterium substituted amine. According to the invention, the ubiquitous problems that only one deuterium atom can be introduced to a nitrogen alpha-site, the synthesis route is tedious, the operation steps are complicated and the existing deuterated amine synthesis technology depends on an expensive deuterium source or a metal catalyst are solved; the invention provides a novel polydeuterium substituted amine synthesis strategy which has the advantages of simple steps, mild conditions, high atom economy and easiness in large-scale production.

The invention discloses a synthesis method of an N, N-alkyl substituted amine compound, which utilizes an optimized Gabriel amine synthesis method, and directly uses phthalimide in the presence of alkali, thereby saving the step of converting the phthalimide into sylvite.

The present invention relates to a method for producing carbamoyl fluoride, etc., characterized by obtaining carbamoyl fluoride by reacting a secondary amine with CF3SO2Na, and by establishing reaction conditions under an oxygen atmosphere along with light irradiation in the presence of a DDQ catalyst, various carbamoyl fluorides can be synthesized from a secondary amine in an environmentally friendly manner and with excellent yield.

The invention discloses a preparation method and application of a high-selectivity boron-containing transition metal catalyst in diglycolamine synthesis, and belongs to the technical field of functional materials. Comprising the following steps: (1) adding active aluminum oxide into deionized water, uniformly dispersing, and adding salt of metal Co, Cu or Ni; (2) introducing nitrogen to replace air, and dropwise adding a hydroboron solution under an ice bath condition until reduction is completed; (3) repeatedly washing with deionized water and absolute ethyl alcohol until the solution is neutral; and (4) drying and grinding. According to the prepared boron-containing transition metal catalyst, the conversion rate of catalyzing the amination reaction of diethylene glycol can reach 90% or above, and the selectivity of generated diglycolamine can reach 80% or above.

The application discloses a method for separating bismuth from actinium, which comprises the following steps: passing a hydrochloric acid or nitric acid solution containing actinium through a cation exchange column, and eluting the cation exchange column with first hydrochloric acid to obtain an eluate containing bismuth (Bi); passing the eluate containing Bi through a TK201 resin column to obtain Bi adsorbed on the TK201 resin column; and eluting the Bi adsorbed on the TK201 resin column with second hydrochloric acid or nitric acid to obtain a Bi eluate. The application uses TK201 resin as a purifying material of Bi for the first time, the TK201 resin is synthesized based on a tertiary amine and doped with a small amount of long-chain alcohol, has specific adsorption on Bi under the condition of a certain concentration of hydrochloric acid, and has no adsorption capacity on Ac and Fr, so that the content of Ac in Bi is greatly reduced.

The invention discloses a method for improving the yield of aromatic or heterocyclic primary amine and reducing accumulation of toxic intermediate aldehyde by utilizing dynamic regulation and control, and belongs to the technical field of gene engineering and fermentation engineering. In order to solve the problem that toxic intermediates are easily accumulated due to metabolism imbalance of carboxylic acid reductase ncCAR and transaminase OATA in the biosynthesis process of cinnamyl amine, promoters P4 and Pd which respond to accumulation of cinnamyl aldehyde are used for respectively regulating the expression levels of the carboxylic acid reductase ncCAR and transaminase OATA in the synthesis route of cinnamyl amine; the accumulation level of a toxic intermediate cinnamyl aldehyde is reduced, so that the inhibition of cinnamyl aldehyde on the activity of engineering bacteria is reduced, and the yield of cinnamyl amine is further improved.

The present application relates to a kind of 2-isopropyl-4-methylpyridine-3-amine synthesis process, with nickel catalyst, Grignard reagent, to carry out one-step Kumada coupling reaction to obtain product 2-isopropyl-4-methylpyridine-3-amine with 2-chloro-3-amino-4-methylpyridine as starting material.The synthesis process of 2-isopropyl-4-methylpyridine-3-amine of the present application, step is short, raw material is easy to obtain, and does not need to use expensive palladium metal catalyst, cost is low, yield is high, process is simple, three wastes are less, suitable for industrial amplification production.

The methylamine synthesis, rectification and purification system comprises a deamination unit, an extraction unit, a dehydration unit, a separation unit and an environment-friendly treatment unit, and the deamination unit comprises a deamination tower, a first tower top condenser, a first reflux tank and a first kettle liquid cooler; the extraction unit comprises an extraction tower, a second tower top condenser, a second reflux tank and a second kettle liquid cooler; the separation unit comprises a first filler rectifying tower, a third tower top condenser, a third reflux tank, a second filler rectifying tower, a fourth tower top condenser and a fourth reflux tank. According to the deamination unit disclosed by the invention, through the cooperation of the deamination tower, the first tower top condenser and other equipment, excessive liquid ammonia in a material after a synthesis reaction can be effectively removed, and the influence of ammonia on the quality of a subsequent product is reduced. Due to the two-way design of the outlet of the first reflux tank, reflux and extraction can be flexibly controlled, and the deamination efficiency and the material utilization rate are improved.

The invention discloses a synthesis process and a synthesis device of clothianidin, and relates to the technical field of clothianidin synthesis, the synthesis device comprises a four-in-one reactor and a preheating cylinder, the four-in-one reactor comprises a stirring mechanism, a vacuum mechanism, a nitrogen valve, a charging valve and a jacket and filtering mechanism, the nitrogen valve is installed on the outer side of the four-in-one reactor, and the charging valve is installed on the outer side of the four-in-one reactor; one end of the jacket is fixedly connected with a third pipeline, the other end of the jacket is provided with a first pipeline, the outer side of the preheating cylinder is fixedly sleeved with a preheating sleeve, and the interior of the preheating cylinder is rotationally connected with a rotating column through a bearing. According to the present invention, the 1, 5-dimethyl-2-nitroiminohexahydro-1, 3, 5-triazine is adopted to replace the 1, 5-dimethyl-2-nitroiminohexahydro-1, 3, 5-triazine to prepare the clothianidin, such that the reaction yield can be improved by more than 10%, and the yield is stable; side reactions are reduced, and the product has few impurities and high purity.

The application provides a coordination metal catalyst, a preparation method and application thereof, a hindered amine and a preparation method thereof. The preparation method of the coordination metal catalyst comprises uniformly mixing a first metal salt and a second metal salt, then adding an amide-substituted benzene, standing, drying to obtain the coordination metal catalyst; the metal element in the first metal salt comprises one of Co, Pd and Ni or a combination of two or more thereof; the second metal salt is triflate and / or chloride. The application further provides the coordination metal catalyst obtained by the above preparation method and a hindered amine catalyst comprising the coordination metal catalyst. The application further provides the hindered amine and a preparation method thereof, which is prepared by using the above hindered amine catalyst. The coordination metal catalyst provided by the application has the advantages of low cost, high catalytic activity, mild reaction conditions and the like, and can be used for the hindered amine and other reactions related to alcohol amine synthesis.

The application discloses a synthesis method of a conjugated diene amide with a full (E) configuration, and belongs to the technical field of conjugated diene amide synthesis. The application realizes the conversion of an unsaturated aldehyde into a conjugated diene carboxylic acid ester by keeping the double bond configuration of the (E)-unsaturated aldehyde as a raw material, the double bond migration of a phosphoryl intermediate is used, the configuration isomerization in the traditional method is avoided, the product configuration is single, continuous reaction reduces separation loss, the total yield is about 20% higher than that of the prior art, the reaction condition is mild, and the method is suitable for industrial production.