295 results about "Acridine derivatives" patented technology

The invention relates to the field of analyzing immunological determination, in particular to a method for immunological detection by combining an acridinium ester labeling technology with general magnetic particles and an immunological determination (quantitative/qualitative) kit which is prepared by utilizing the method. According to the method disclosed by the invention, substances, such as acridinium ester or acridine sulfonamide are used for labeling and detecting an antigen or an antibody, biotin is used for labeling and capturing the antigen or the antibody, and the immunological determination of biomolecules is carried out by combining the general (chain enzyme) avidin labeled magnetic particles. The method disclosed by the invention has the advantages of high sensitivity, wide detection range and capabilities of realizing the automation easily and having a wide application prospect in the field of the immunological detection.

The invention relates to a thermal activation delayed fluorescent material with a general formula of the structure shown as the formula (I) or the formula (II). D is one of phenoxazinyl, phenothizainyl, 9,9-dimethyl acridine, 9-methyl phenazinyl, 9-phenyl phenazinyl, 4-phenoxazinyl-1-phenyl, 4-phenothizainyl-1-phenyl, 4-(9,9-dimethyl)acridinyl-1-phenyl, 4-(9-methyl)-phenazinyl-1-phenyl, 4-(9-phenyl)phenazinyl-1-phenyl and 3,5-bis-carbazolyl-1-phenyl. The invention further relates to an organic electroluminescent device which comprises a light-emitting layer, and luminescent dye of the light-emitting layer is the thermal activation delayed fluorescent material. The singlet state-triplet state energy gap (delta EST) of the thermal activation delayed fluorescent material is very small, triplet state excitors can be converted into singlet state excitors through inverse intersystem crossing (RIST) to emit light, and the efficiency and stability of an OLED device can be improved. The formula is shown in the description.

The invention relates to a kit for detecting neutrophil gelatinase-associated lipocalin content based on chemiluminescence immunoassay. According to the invention, by employing a double-antibody sandwich immunization analysis method, a chemiluminescence magnetic microspheres immunization technology is used, anti-NGAL antibody-coated magnetic microspheres for specifically combining with NGAL antigen of a standard substance/sample in a reaction cup, then are reacted to another strain anti-NGAL antibody labelled with acridine salt to form an immunization compound, through an acid-base chemical reaction of a pre-Trigger and a Trigger, relative light unit (RLU/s) of the chemiluminescence reaction can be measured; the NGAL antigen content in the sample is in direct proportion to the relative light unit (RLU/s) measured by an optical system, determination of NGAL content in an urine specimen can be determined through standard curve fitting; and the method has the obvious advantages of high sensitivity, strong specificity, good stability, simple operation and low cost.

Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 1 μm to about 200 μm. The matrix can be fibrous, and the particles can have a surface area greater than 750 m²/g and a pore diameter between about 25 and 800 Å. The device can be used to adsorb and remove a pathogen-inactivating compound that is a nucleic acid-binding compound such as psoralen, an acridine derivative or a dye from a biological composition such as a blood product.

The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a 5-HT2B antagonist.

The invention relates to novel acridine derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for the treatment of tumors.

The invention relates to a chemical illumination immunity analysis method for checking human cTnT, which uses acridiniumester and/or alkaline phosphatase as label. The immunity reaction uses two-site immunoassay and/or competition law. The immunity reaction can use streptavidin-biotin two-site immunoassay to improve sensitivity. The invention uses NaOH and H2O2 as acridiniumester illumination initiating agent, uses 1, 2-dioxo cyclohexane derivative (adamantine derivative) as the illumination substrate of alkaline phosphatase, and uses fluorescein derivative and surface activator as illumination renforcing agent. The solid carrier is orifice plate, macromolecule polymer tube (ball) and ferriferrous oxide magnetic particles or the like.

The invention relates to acridine derivatives of which the structure is disclosed as Formula (1). When the electronic transmission layer of the electroluminescent device is prepared from the material provided by the invention, the turn-on voltage of the device can be lowered, the luminescence efficiency of the device can be enhanced, and the service life of the device can be prolonged.

The invention relates to a 9-phenylacridine photoinitiator and a preparation method thereof, wherein 9-phenylacridine (compound 1) and some 9-(substituted phenyl) acridine compounds such as 9-(4-methyl phenyl) acridine (compound 2), 9-(3-methyl phenyl) acridine (compound 3), 9-(2-methyl phenyl) acridine (compound 4) and 9-(2-chlorophenyl) acridine (compound 5) can be used as a photoinitiator and is widely used for unsaturated resin and light-cured materials formed by monomers of the unsaturated resin. The preparation method takes diphenylamine as starting materials, and the diphenylamine is directly reacted with benzoic acid or substituted benzoic acid under the catalysis of a composite catalyst formed by zinc chloride and 85 percent phosphoric acid to produce the 9-phenylacridine (compound 1) and the 9-(substituted phenyl) acridine compounds 2 to 5, thereby the yield of the compounds 1 to 5 can reach above 70 percent, all the product purities are larger than 98 percent, and the technology can satisfy the requirements of industrial production.

The invention discloses a 9,9'-spiral acridine-containing compound. 9,9'-spiral acridine is taken as a core and the 9,9'-spiral acridine is combined with peripheral electrophilic Ar and Ar' units. The invention further discloses a preparation method of the 9,9'-spiral acridine-containing compound. The 9,9'-spiral acridine-containing compound is obtained through selecting different halogen-substituted Ar unit and Ar' unit, carrying out Buchwald-Hartwig coupled reaction on 10H, 10'H-9,9'-spiral acridine, carrying out copper-catalyzed aryl halide amination reaction or carrying out nucleophilic substitution reaction under a strong alkaline condition. The invention further discloses an application of the 9,9'-spiral acridine-containing compound. The 9,9'-spiral acridine-containing compound has high fluorescence and certain conductivity, and can be used for fabricating a light-emitting layer of an organic light-emitting diode as a luminous body.

The invention belongs to the field of organic photoelectric material technology, and discloses an organic small molecule luminescent material and an organic electroluminescent device prepared from same. The organic small molecule luminescent material uses 9,9-dimethyl-10- phenyl acridine or 10-phenyl phenoxazine as an electron providing unit, and is connected with a different electron withdrawing unit at 2-site of the acridine group or the 3-site of the phenoxazine group to obtain a series of novel efficient organic small molecule luminescent materials. The organic small molecule luminescent material can change the characteristic of intramolecular charge transfer in the material, can make the luminescence peak of the luminescent material has a blue-shift, can be used as a luminescent layer for the organic electroluminescent device, and has a high device efficiency.

Acridine containing cisplatin compounds have been disclosed that show greater efficacy against cancer than other cisplatin compounds. Methods of delivery of those more effective cisplatin compounds to the nucleus in cancer cells is disclosed using one or more amino acids, one or more sugars, one or more polymeric ethers, C_1-6alkylene-phenyl-NH—C(O)—R₁₅, folic acid, α_vβ₃ integrin RGD binding peptide, tamoxifen, endoxifen, epidermal growth factor receptor, antibody conjugates, kinase inhibitors, diazoles, triazoles, oxazoles, erlotinib, and/or mixtures thereof; wherein R₁₅ is a peptide.

The invention provides a novel acridine compound and organic light-emitting devices thereof, belongs to the technical field of organic photoelectric materials, and aims to solve the technical problems of low light-emitting efficiency, high driving voltage, short service life and low light-emitting performance of the organic photoelectric material in the prior art. Compared with the prior art, the light-emitting performance of the organic light-emitting devices based on organic electroluminescence device compounds and ink compositions can be obviously improved; the novel acridine compound is used as an excellent OLED material.

The invention discloses an acridine derivative represented by the formula I and a preparation method and application thereof. The formula I represents a compound or a medically accepted salt, ester and solvent composition thereof; Z is NHCH2, NHCH2CH2, NHCH2CH2CH2 or OCH2; the compound represented by the formula I has a deoxyribonucleic acid (DNA) connection function and inhibition activity to topoisomerase; the compound or the medically accepted salt, ester and solvent composition thereof can be effectively used for preparing a DNA connector, a topoisomerase inhibitor and an eucaryon biological tumor cell multiplication inhibitor and tumor preventing and/or treating medicines.

Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. These biosensor molecules address the problem of obtaining fluorescence emission at wavelengths greater than about 500 nm. Biosensor molecules generally include an (1) an acridine-based fluorophore, (2) a linker moiety and (3) a boronate substrate recognition/binding moiety, which binds polyhydroxylate analytes, such as glucose. These biosensor molecules further include a “switch” element that is drawn from the electronic interactions among these submolecular components. This fluorescent switch is generally “off” in the absence of bound polyhydroxylate analyte and is generally “on” in the presence of bound polyhydroxylate analyte. Thus, the reversible binding of a polyhydroxylate analyte essentially turns the fluorescent switch “on” and “off”. This property of the biosensor molecules, as well as their ability to emit fluorescent light at greater than about 500 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.

A method for the detection or quantitation of an analyte in a biological sample is disclosed. The method comprises the steps of selecting a biological sample suspected of containing a target analyte and binding the target analyte in the sample to a binding partner conjugated to an acridinium compound, wherein the acridinium compound comprises an acridinium nucleus having an electron-donating substituent directly attached to the acridinium nucleus at the C₂ position. Chemiluminescent acridinium compounds useful in the method have emission maxima close to or in the near infrared (NIR) region (>590 nm). These chemiluminescent acridinium compounds when used in conjunction with short wavelength-emitting acridinium esters (with emission maxima below 450 nm) can be highly useful labels for the simultaneous detection of multiple target analytes in a single assay.

The present invention relates to a negative photosensitive resin composition which is sensitive to long wavelength ultraviolet rays, and more specifically, to a negative photosensitive resin composition comprising: a) one or a mixture of copolymers selected from i) an acrylic copolymer, ii) a polyimide-based copolymer, and iii) a siloxane-based copolymer; b) a photoinitiator; and c) an acridine-based photosensitizer having a specific structure. According to the present invention, the negative photosensitive resin composition has excellent resolution, transmittance, thermochromism resistance, adhesive force and the like, particularly, has excellent sensitivity at long wavelength ultraviolet rays of 405-435 nm, and thus is appropriate for use in an exposure device for the exclusive use of GH-line or a next generation digital exposure device.

This invention provides an electrode electrolyte for a solid polymer-type fuel cell, in which a cost problem and a problem related to recovery of catalyst metals are solved, having excellent proton conductivity, dimensional stability and heat resistance.

An electrode electrolyte for a solid polymer electrolyte-type fuel cell contains a polymer, which has a polyphenylene structure as a main chain and both a sulfonic acid group and a nitrogen-containing heterocyclic group as a side chain. A side chain having the nitrogen-containing heterocyclic group has a structure represented by the following general formula (D).

(In formula, Z represents at least one kind of structures selected from a group consisting of a direct bond, —O— and —S—, Y represents at least one kind of structures selected from a group consisting of —CO—, —SO₂—, —SO—, —CONH—, —COO—, —(CF₂)₁— (1 is an integer of 1 to 10) and —C(CF₃)₂— and R²⁰ represents a nitrogen-containing heterocyclic group. q represents an integer of 1 to 5 and p represents an integer of 0 to 4.)

The above nitrogen-containing heterocyclic group is at least one kind of group derived from a compound selected from the group consisting of nitrogen-containing heterocyclic compounds including pyrrole, thiazole, isothiazole, oxazole, isoxazole, pyridine, imidazole, imidazoline, pyrazole, 1,3,5-triazine, pyrimidine, pyridazine, pyrazine, indole, quinoline, isoquinoline, purine, benzimidazole, benzoxazole, benzothiazole, tetrazole, tetrazine, triazole, carbazole, acridine, quinoxaline and quinazoline and derivatives thereof.

The invention discloses an orange red light thermal activated delay fluorescent material which is 3,6,11-tri(9,9-dimethyl acridine-10(9H)-yl)-dibenzo[a,c] phenazine (3DMAC-BP). The fluorescent material has a rigid large-plane twisted structure and a remarkable internal charge transfer (ICT) effect, has an organic red thermal activated delay fluorescence property (TADF), a high fluorescence quantumyield (PLQY) and excellent thermal stability, and is simple in synthesis preparation steps, and raw materials are easy to obtain, synthesis and purification processes are simple, the yield is high and large-scale synthesis and preparation can be achieved. The organic electroluminescence device based on the material is capable of emitting orange red fluorescence (lambda=606nm), the external quantum efficiency EQE of the device is as high as 22%, and the device has the advantages of being low in driving voltage, good in light emission stability, and the like, and has good application prospectsin fields such as lighting, panel display, sensation, night vision, bioimaging and the like.