191 results about "Isothiazole" patented technology

Provided is a heterocyclic compound having an RORγt inhibitory activity. A compound represented by the formula (I):

wherein

• • ring A is an optionally substituted cyclic group,
  • Q is a bond, optionally substituted C_1-10 alkylene, optionally substituted C_2-10 alkenylene, or optionally substituted C_2-10 alkynylene,
  • R¹ is a substituent,
  • ring B is a thiazole ring, an isothiazole ring or a dihydrothiazole ring, each of which is optionally further substituted by a substituent in addition to R², and
  • R² is an optionally substituted cyclyl-carbonyl-C_1-6 alkyl group, an optionally substituted aminocarbonyl-C_1-6 alkyl group, an optionally substituted cyclyl-C_1-6 alkyl group, an optionally substituted cyclyl-C_1-6 alkylamino-carbonyl group, an optionally substituted aminocarbonyl-C_2-6 alkenyl group, an optionally substituted C_1-6 alkylcarbonylamino-C_1-6 alkyl group, an optionally substituted cyclyl-aminocarbonyl group, an optionally substituted cyclyl-carbonyl group or an optionally substituted non-aromatic heterocyclic group, or a salt thereof.

The polishing solution for CMP of the invention comprises abrasive grains, a first additive and water, wherein the first additive is at least 1,2-benzoisothiazole-3(2H)-one or 2-aminothiazole. The polishing method of the invention is a polishing method for a substrate having a silicon oxide film on the surface, and the polishing method comprises a step of polishing the silicon oxide film with a polishing pad while supplying the polishing solution for CMP between the silicon oxide film and the polishing pad.

The invention relates to a disinfectant used in anti-penetrate film and relative preparing method. It is characterized in that: said disinfectant is formed by C4H4CLNOS C4H5NOS, bromine nitrogen isothiazole, bromine nitro compound, solvent and water. In the room temperature that under 50Deg. C, adding deionized water or anti-penetrate water; adding solvent into reaction kettle; adding bromine nitrogen isothiazole to be mixed and dissolved; adding bromine nitro compound; and adding C4H4CLNOS C4H5NOS to be mixed for 20-30mins.

A microbicidal composition containing: (a) at least one non-halogenated 2-alkyl-4-isothiazolin-3-one selected from substituted and unsubstituted 2-(C1-C4)alkyl-4-isothiazolin-3-ones; and (b) at least one of 2,2'-dithiobis(N-methylbenzamide) and 2-methylbenzisothiazolone.

Isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is -CH2-, -SO-, -O-, -SO2-, or -S-; compositions comprising the isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.

This invention provides an electrode electrolyte for a solid polymer-type fuel cell, in which a cost problem and a problem related to recovery of catalyst metals are solved, having excellent proton conductivity, dimensional stability and heat resistance.

An electrode electrolyte for a solid polymer electrolyte-type fuel cell contains a polymer, which has a polyphenylene structure as a main chain and both a sulfonic acid group and a nitrogen-containing heterocyclic group as a side chain. A side chain having the nitrogen-containing heterocyclic group has a structure represented by the following general formula (D).

(In formula, Z represents at least one kind of structures selected from a group consisting of a direct bond, —O— and —S—, Y represents at least one kind of structures selected from a group consisting of —CO—, —SO₂—, —SO—, —CONH—, —COO—, —(CF₂)₁— (1 is an integer of 1 to 10) and —C(CF₃)₂— and R²⁰ represents a nitrogen-containing heterocyclic group. q represents an integer of 1 to 5 and p represents an integer of 0 to 4.)

The above nitrogen-containing heterocyclic group is at least one kind of group derived from a compound selected from the group consisting of nitrogen-containing heterocyclic compounds including pyrrole, thiazole, isothiazole, oxazole, isoxazole, pyridine, imidazole, imidazoline, pyrazole, 1,3,5-triazine, pyrimidine, pyridazine, pyrazine, indole, quinoline, isoquinoline, purine, benzimidazole, benzoxazole, benzothiazole, tetrazole, tetrazine, triazole, carbazole, acridine, quinoxaline and quinazoline and derivatives thereof.

The invention provides a preparation method of lurasidone. On the basis of the existing preparation method of lurasidone, a one-pot method is adopted to replace the method including multiple steps and obtain a target product once. The preparation method comprises the following steps: adding 3-(1-piperazinyl)-1,2-benzisothiazole in toluene, stirring to dissolve; adding (1R,2R)-1,2-bis(methanesulfonyloxymethyl)cyclohexane and an inorganic alkali, heating and carrying out reflux reaction for 12-36 hours; adding (3alpha R,4S,7R,7alpha S)4,7-methano-1H-isoindole-1,3(2H)-dione; heating and refluxing; recycling toluene at reduced pressure; adding ethyl acetate in the residue, stirring to dissolve, washing for 2-3 times with 5% hydrochloric acid, separating out the organic layers, drying for 20-120 minutes, filtering to remove the drying agent, concentrating the obtained ethyl acetate solution, dropwise adding concentrated hydrochloric acid, precipitating the solid, and performing suction filtration to obtain crude lurasidone; and refining crude lurasidone to obtain pure lurasidone. By adopting the preparation method of lurasidone, the solvent can be recycled conveniently and the method is simple in operation.

The invention discloses a hydrophilic antibacterial coating of aluminum-foil paper for cigarettes. The hydrophilic antibacterial coating is prepared from polyvinyl butyral (PVB) resin, polyacrylamide (PAM) resin, isothiazolone, a chitosan-copper complex, GR organic dye yellow, GR organic dye red, GR organic dye black, tap water, polyethylene wax as an antiwear agent, titanium dioxide, rosin and 95% ethanol. The coating is beneficial to the improvement of the quality and definition of a printed product, has good water resistance, is low in volatile substance content and strong in practicability, has excellent printing viscosity stability and low-combustion safety,is capable of improving the working environments of printing workers, simplifying the printing cleaning workload and increasing the production efficiency and can be popularized in food packaging and printing industries.

High pH aqueous coating compositions containing 3-isothiazolone microbicide that have been stabilized against the degradation of the 3-isothiazolone by the addition of low levels of copper ion are disclosed. In particular, aqueous paint compositions containing pH-adjusting amine compounds, where the pH is above 9.5, are effectively stabilized when 1 to 200 ppm of copper ion is added to the paint composition before the 3-isothiazolone is combined with other paint components or if copper ion is added together with the 3-isothiazolone to the remaining paint components or if the 3-isothiazolone is added no more than 1 hour before copper ion is added to the composition.

The invention provides a preparation method of a precious cream for deeply whitening and moistening skin, which comprises the following steps: according to parts by weight, taking and adding 0.1-0.2 part of bisabolol into an oil tank, sequentially adding 1.3-1.8 parts of glyceryl stearate citrate, 0.5-0.7 part of beheneth-25, 3-5 parts of cetearyl alcohol, 2.0-2.2 parts of ethylhexyl palmitate, 2-4 parts of mineral oil, 0.8-1.2 parts of di-C12-13 alkyl malate and 2.5-3.2 parts of dimethyl polysiloxane, and heating to 80-88 DEG C; adding 73-78 parts of deionized water into a water tank, heating to 55-65 DEG C, adding 3-6 parts of glycerol and 0.2-0.5 part of allantoin, and heating to 80-88 DEG C; dissolving 0.3-0.7 part of lycopene by utilizing ethylhexyl palmitate for use; preheating and vacuumizing a main tank, sucking the materials in the oil tank and the water tank into the main tank, homogenizing for 7-9 minutes, adding 1.0-1.2 parts of polyacrylamide, and stirring for 2-3 minutes; when the temperature is reduced to 50 DEG C, adding the lycopene, and homogenizing for 2-3 minutes; when the temperature is reduced to 45 DEG C, adding 0.1-0.2 part of benzyl alcohol/chloromethyl isothiazolinone/methyl isothiazolinone, 1.5-2.2 parts of collagen, 0.02-0.04 part of rose essence and 0.5-1.2 parts of polyquaternium-51; and when the temperature is reduced to 40 DEG C and the pH value is 4.0-7.5, discharging.

The invention provides a chloroisothiazole neonicotine compound, as well as a preparation method and application thereof. The 3,4-dichloroisothiazole neonicotine compound has a chemical structural general formula as shown in a formula I. The formula is as shown in the specification. The invention further discloses a structure general formula, a synthesizing method of the compound, application of the compound as insecticides, bactericides and plant virucides, application of a composition of the compound, agriculturally acceptable auxiliary or synergist and commercial insecticide, bactericide, plant virucdies and acaricides in prevention and control of insect pests, diseases and virus diseases of agricultural, forestal and horticultural plants and a preparation method of the composition.

The invention discloses a making method of qilaxi ketone with structural formula as formula (I), which is characterized by the following: the chemical name of compound is 5-(2-(4-(1,2-benzo isothiazole-3-base)-piperazine) acetyl)-6-chloride-1, 3-dihydrogen-2H-indole-2-ketone, which is reduced in the organic acid solvent; the solvent is C1-C6 paraffin acid substituted by at least one halogenate atom with carboxyl function group.

The invention discloses an electrolyte additive for improving high-temperature flatulence of a battery, and relates to the technical field of lithium ion batteries, the additive comprises a 1,3-diphosphate-isothiazole compound and a water removal additive. The structural general formula of the 1,3-diphosphate-isothiazole compound is shown in the specification, wherein R1 and R2 are respectively and independently selected from one of H, C1-8 alkyl, C4-10 cycloalkyl, C2-10 alkenyl, C2-10 alkynyl, C6-16 aryl, C6-16 heteroaryl and part of fluoro or perfluoro compounds of the H, the C1-8 alkyl, the C4-10 cycloalkyl, the C2-10 alkenyl, the C2-10 alkynyl, the C6-16 heteroaryl and the part of fluoro or perfluoro compounds of the C6-16 heteroaryl. The invention also provides an electrolyte containing the additive and a lithium ion battery. The electrolyte has the beneficial effects that the special high-temperature gas expansion improving additive is added into the electrolyte, so that the reaction between the electrolyte and positive and negative electrode materials in the lithium ion battery under a high-temperature condition is inhibited, the stability of the positive and negative electrode materials under a high-temperature environment is improved, and the storage gas expansion and cycle performance of the battery under the high-temperature condition is improved.

The invention discloses a benzo isothiazole azo pyrazolone disperse dye. The benzo isothiazole azo pyrazolone disperse dye is a compound having the structure shown in a formula (I) in the specification. Conjugate migration of hydrogen connected with a heteroatom in the benzo isothiazole azo pyrazolone heterocyclic ring disperse dyes is performed among benzo isothiazole ring, azo and pyrazolone to display bright-colored yellow, red and blue; and moreover, the dye is large in hue span and rich in colors; and therefore, the benzo isothiazole azo pyrazolone disperse dye can be used for preparing a fiber identification coloring agent. The invention discloses a preparation method of the benzo isothiazole azo pyrazolone disperse dye.

A water-dispersing tablet of probenazole as plant growth regulator with high activity to rice blast is proportionally prepared from probenazole, disintegrant, adhesive, disperser, wetting agent and filler through mixing, pulverizing, sieving and die pressing.

A topical formulation comprising a first active agent that is pharmaceutically acceptable salt of a cationic bisbiguanide such as chlorhexidine digluconate (CHG), a secnd active agent which is a cationic quaternary ammonium compound such as cetylpyridinium chloride (CPC), methylisothiazolone, or chloroxylenol, and a propellant; and an aerosol dispenser containing the topical formulation. The topical formulation can be sprayed onto exposed skin to prevent or reduce the risk of skin infection.