Methods for treating inflammatory conditions or inhibiting JNK

a technology of inflammatory conditions and inhibitors, applied in the direction of antinoxious agents, drug compositions, extracellular fluid disorders, etc., can solve the problems of cell death and scar formation, congestive heart failure, renal failure, or cerebral dysfunction, and selective defect in the ability of th1 effector cells to express ifng
US20040092562A1Inactive Publication Date: 2004-05-13SIGNAL PHARMA LLC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
SIGNAL PHARMA LLC
Publication Date
2004-05-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention is generally directed to methods for treating or preventing a disease or disorder comprising administering to a patient in need thereof an effective amount of a Jun N-terminal kinase (JNK) inhibitor, such as an isothiazoloanthrone, isoxazoloanthrone, isoindolanthrone, or derivative thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein Ro is -CH2-, -SO-, -O-, -SO2-, or -S-.
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Description

[0001] This application is a continuation-in-part of U.S. application Ser. No. 10 / 071,390 filed Feb. 7, 2002 which claims the benefit of U.S. Provisional Application No. 60 / 269,013 filed Feb. 15, 2001, each of which is incorporated by reference herein in its entirety.1. FIELD OF THE INVENTION

[0002] This invention is generally directed to methods for treating or preventing a disease or disorder comprising administering to a patient in need thereof an effective amount of a Jun N-terminal kinase ("JNK") inhibitor, such as an isothiazoloanthrone, isoxazoloanthrone, isoindolanthrone, or derivative thereof, including pharmaceutically acceptable salts thereof.2. BACKGROUND OF THE INVENTION

[0003] The Jun N-terminal kinase pathway is activated by exposure of cells to environmental stress or by treatment of cells with pro-inflammatory cytokines. Targets of the JNK pathway include the transcription factors c-jun and ATF2 (Whitmarsh A. J., and Davis R. J. J. Mol. Med. 74:589-607, 1996). These t...

Claims

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