The invention discloses a finishing agent composition for cotton-silk fabrics. The finishing agent composition comprises the following ingredients by weight: 120 to 180 parts of dihydroxy ethylene-urea resin, 10 to 60 parts of a powerful protecting agent, 10 to 50 parts of a smoothing agent, 30 to 80 parts of a softening agent, 10 to 25 parts of a catalyst, 5 to 10 parts of an anti-fraying agent, 1 to 5 parts of a penetrating agent, and 5 to 10 parts of a formaldehyde scavenger. The invention further provides a processing method of a cotton-silk easy-care shirt. The processing method of the cotton-silk shirt garment comprises the following steps: prewashing, drying, material spraying, pre-drying, pressing, baking, purified water washing, drying and moisture regaining, wherein the finishing agent composition is uniformly applied onto the cotton-silk easy-care shirt in the material spraying step. The finishing agent composition is used for finishing process of the cotton-silk fabrics, and can be used for overcoming the defect that the anti-sliding property of the cotton-silk fabrics is lowered after conventional easy-care treatment, reserving the own moisture permeability, air permeability and natural drapability of the cotton-silk fabrics, and enabling the cotton-silk fabrics to have relatively high easy-care property. Therefore, people can wear the shirt comfortably, and the shirt is easy to care. Moreover, the formaldehyde content of the finished cotton-silk easy-care shirt can be lower than the national standard.