Enterococcus exopolysaccharide with immunomodulatory effect as well as preparation method and application of enterococcus exopolysaccharide

An extracellular polysaccharide, immune regulation technology, applied in microorganism-based methods, biochemical equipment and methods, bacteria, etc., can solve the problems of rare immune regulation and less research on biological activity, and achieve significant technical advantages and applications. Clear range, proliferative effect
CN112852902AActive Publication Date: 2021-05-28NANCHANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANCHANG UNIV
Publication Date
2021-05-28

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Abstract

The invention discloses an enterococcus exopolysaccharide with an immunomodulatory effect as well as a preparation method and application of enterococcus exopolysaccharide; enterococcus hiraei WEHI01 is used for fermentation to generate the exopolysaccharide, the exopolysaccharide is separated and purified, and the enterococcus hiraei WEHI01 is preserved in the China Center for Type Culture Collection, and has the preservation number of CCTCC NO:M 2019068. The prepared enterococcus exopolysaccharide comprises four components: EPS-I01, EPS-I02, EPS-I03 and EPS-I04, the average molecular weight of the component EPS-I02 is 2.28*10<4> Da, and the component EPS-I02 is composed of rhamnose, trehalose, arabinose, xylose, mannose, glucose and galactose according to the molar ratio of 1:1.76:5.48:1.76:2.52:6.2:20.92. The enterococcus exopolysaccharide prepared by the preparation method has an immunoregulation effect, can significantly improve the proliferation rate and phagocytic ability of macrophages, and significantly promote macrophages to secrete NO and cell factors, and the enterococcus exopolysaccharide as an additive is applied to the fields of food and medicine, and has a wide application prospect.
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Description

technical field

[0001] The invention relates to the technical field of polysaccharides in microbiology, in particular to an enterococcal exopolysaccharide with immune regulation function and its preparation method and application. Background technique

[0002] Lactic acid bacteria (LAB), generally refers to bacteria that utilize fermentable carbohydrates and produce a large amount of lactic acid, and are recognized as green and safe (GRAS) food-grade microorganisms. In addition to producing lactic acid, acetic acid, formic acid and folic acid, lactic acid bacteria also produce other secondary metabolites, such as bacteriocin and exopolysaccharides. The exopolysaccharide of lactic acid bacteria can not only improve the texture and flavor of fermented dairy products, such as thickening, stabilizing, emulsifying, gelling and water holding, etc.; it also has a variety of physiological functions, including promoting cell adhesion, anti-oxidation, lowering cholesterol, Anti-tumor...

Claims

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