The invention provides a prescription for treating bladder calculi. The prescription comprises, by weight, 30g of salix babylonica leaf, 30g of phaseolus calcaratus, 30g of stigma maydis, 15g of talcum powder and 15g of cortex phellodendri. The prescription for treating the bladder calculi has the advantages that the prescription is applicable to patients, of various ages, with the bladder calculi, and the prescription is capable of comprehensively regulating the functions of internal organs such as the kidney, spleen and liver by using the concept of communicating the whole body, tonifying the kidney and benefiting qi, restoring the water controlling and qi transformation managing functions of the kidney, further preventing feculence from precipitating to form the calculi, strengthening and activating the spleen, dispelling dampness and promoting diuresis, allowing urine not to be heated to form the calculi, soothing the liver and regulating qi at the same time, allowing qi formation and qi rise and fall to be performed orderly, and allowing water to circulate normally to make calculi formation difficult; after the passages for forming new calculi possibly are blocked, the medicine effects of regulating qi and relieving pain, promoting diuresis and removing blood stasis, eliminating stagnation and dredging blocking, and treating stranguria and discharging the calculi of the prescription are actually brought into play, and the bladder calculi is cured comprehensively.