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Application of raspberry polysaccharide in prevention or treatment of side effects of chemotherapeutic drugs

A technology of raspberry polysaccharides and chemotherapy drugs, which is applied in the field of medicine and can solve problems such as raspberry polysaccharides that have not yet been seen

Active Publication Date: 2018-06-22
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant research on the effect of raspberry polysaccharides on chemotherapy drugs

Method used

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  • Application of raspberry polysaccharide in prevention or treatment of side effects of chemotherapeutic drugs
  • Application of raspberry polysaccharide in prevention or treatment of side effects of chemotherapeutic drugs
  • Application of raspberry polysaccharide in prevention or treatment of side effects of chemotherapeutic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Inhibitory effect of docetaxel-raspberry polysaccharide combination on xenograft tumor growth in melanoma B16F10 mice

[0041] Take melanoma cells B16F10 in the logarithmic growth phase and prepare 5×10 7 / ml cell suspension, inoculated subcutaneously in the right armpit of C57BL / 6 mice with 0.1ml. After 5 days, measure the diameter of the mouse transplanted tumor with a vernier caliper, and wait until the tumor grows to 60-90mm 3 Animals were then randomly grouped. Using the method of measuring tumor diameter, dynamically observe the antitumor effect of the tested drug. Tumor diameter was measured once every 2 days, and the weight of the mouse was also weighed at the same time as each measurement. The grouping and administration methods are as follows: the docetaxel group was injected subcutaneously, 10 mg / kg, once every three days. In the docetaxel-raspberry polysaccharide low-medium-high combined administration group, docetaxel was injected subcutaneously at 10 m...

Embodiment 2

[0047] Inhibitory test of cisplatin-raspberry polysaccharide combination on the growth of human lung cancer H460 xenograft tumor in nude mice

[0048] Tumor cells in the logarithmic growth phase were taken and prepared under sterile conditions into 5×10 7 / ml cell suspension, inoculated subcutaneously in the right armpit of nude mice with 0.1ml. Use a vernier caliper to measure the diameter of the transplanted tumor in nude mice, and wait until the tumor grows to 100-200mm 3 Animals were then randomly grouped. Using the method of measuring tumor diameter, dynamically observe the anti-tumor effect. Tumor diameter was measured once every 2 days, and the weight of the mouse was also weighed at the same time as each measurement. The administration method was as follows: the negative control group was injected with the same amount of normal saline, once a day; the cisplatin group was given 10 mg / kg, once a week; in the cisplatin-raspberry polysaccharide combined administration g...

Embodiment 3

[0058] Inhibitory test of paclitaxel-raspberry polysaccharide combination on human liver cancer Bel-7402 xenograft tumor growth in nude mice

[0059] The specific embodiment is with reference to embodiment 2. The dosing regimen was as follows: the negative control group was injected with the same amount of normal saline, once a day; the paclitaxel group was given 10 mg / kg, once a week; the paclitaxel-raspberry polysaccharide combined administration group was subcutaneously injected with 10 mg / kg. kg, administered once a week, raspberry polysaccharides were administered orally, and the dosages were 100mg / kg, 200mg / kg, and 400mg / kg, administered once a day.

[0060] Table 3. Inhibitory effect of paclitaxel-raspberry polysaccharide on tumor growth of human liver cancer Bel-7402 xenograft in nude mice

[0061]

[0062] Results: See Table 3 and image 3 , the tumor inhibition rate of paclitaxel 10mg / kg group on human liver cancer Bel~7402 nude mouse transplanted tumor was 68.5...

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Abstract

The invention provides application of raspberry polysaccharide in the preparation of medicament for preventing or treating toxic and side effect of chemotherapeutics. After using chemotherapeutics, the human body certainly produces toxic side effects, such as liver, kidney and / or spleen injury. The research of the present invention find that raspberry polysaccharide can effectively reduce the side effects of organ damage caused by the chemotherapeutics, and in particular amount can reduce toxic and side effect but not reduce the curative effect of chemotherapeutics, and even enhance the curative effect, so as to provide novel options for clinical medication of cancer patients.

Description

technical field [0001] The invention belongs to the field of medical science and technology, and in particular relates to a new application of raspberry polysaccharide. technical background [0002] Malignant tumors are still major diseases that seriously threaten human life. Recent statistics show that about 20 million cancer patients are newly discovered every year in my country, and 1.5 million of them die from cancer. Cancer deaths account for 1 / 5 of all deaths. [0003] Currently, the most common method of treating cancer is still chemotherapy. However, due to the non-specific cytotoxicity of chemical drugs, severe side effects such as myelosuppression, mucositis, dermatitis, diarrhea, and organ damage will occur. Due to the existence of severe toxic side effects, many patients are reluctant to adhere to treatment. How to reduce the toxic and side effects of chemotherapy drugs has always been a problem that medical personnel pay close attention to. [0004] Raspber...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P39/02A23L33/125C08B37/00
Inventor 索有瑞杨永晶叶英韩丽娟
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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