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Application of raspberry polysaccharide in preventing or treating toxic and side effect of chemotherapeutics

A technology of raspberry polysaccharide and chemotherapeutic drugs, applied in the field of medicine, can solve problems such as raspberry polysaccharide which have not been seen yet

Active Publication Date: 2015-08-26
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant research on the effect of raspberry polysaccharides on chemotherapy drugs

Method used

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  • Application of raspberry polysaccharide in preventing or treating toxic and side effect of chemotherapeutics
  • Application of raspberry polysaccharide in preventing or treating toxic and side effect of chemotherapeutics
  • Application of raspberry polysaccharide in preventing or treating toxic and side effect of chemotherapeutics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Inhibitory effect of combination of docetaxel and raspberry polysaccharide on tumor growth of melanoma B16F10 xenograft in mice

[0041] Take the melanoma cell B16F10 in the logarithmic growth phase and prepare it into 5×10 under aseptic conditions 7 / ml cell suspension was inoculated subcutaneously in the right axilla of C57BL / 6 mice with 0.1ml. After 5 days, use a vernier caliper to measure the diameter of the transplanted tumor in the mouse, and wait until the tumor grows to 60~90mm 3 The animals were randomly divided into groups. Use the method of measuring tumor diameter to dynamically observe the anti-tumor effect of the tested drug. The number of measurements of tumor diameter is once every 2 days, and the weight of the rat needs to be weighed at the same time for each measurement. The grouping and administration methods are as follows: the docetaxel group was injected subcutaneously, 10 mg / kg, once every three days. Docetaxel ~ raspberry polysaccharide low, mediu...

Embodiment 2

[0047] Cisplatin-Raspberry Polysaccharide Combination on Growth Inhibition of Human Lung Cancer H460 Xenograft Tumor in Nude Mice

[0048] Take the tumor cells in the logarithmic growth phase and prepare them into 5×10 under aseptic conditions 7 / ml cell suspension, inoculated subcutaneously in the right armpit of nude mice with 0.1ml. Measure the diameter of the transplanted tumor in nude mice with a vernier caliper, and wait until the tumor grows to 100~200mm 3 The animals were randomly divided into groups. Use the method of measuring tumor diameter to dynamically observe the anti-tumor effect. The number of measurements of tumor diameter is once every 2 days, and the weight of the rat needs to be weighed at the same time for each measurement. The method of administration is as follows: the negative control group is injected with the same amount of normal saline, once a day; the cisplatin group is administered at 10 mg / kg, once a week; the cisplatin-raspberry polysaccharide lo...

Embodiment 3

[0058] The inhibitory test of paclitaxel-raspberry polysaccharide combination on human liver cancer Bel-7402 xenograft tumor growth in nude mice

[0059] Refer to Example 2 for the specific implementation. The dosage regimen is as follows: the negative control group is injected with the same amount of saline once a day; the paclitaxel group is administered at 10 mg / kg, once a week; the paclitaxel-raspberry polysaccharide low, medium and high combined administration group, paclitaxel is injected subcutaneously, 10 mg / kg, once a week, raspberry polysaccharides are administered by gavage, the dosages are 100mg / kg, 200mg / kg, 400mg / kg, once a day.

[0060] Table 3. Inhibitory effect of paclitaxel~raspberry polysaccharide on the growth of human liver cancer Bel~7402 xenograft tumor in nude mice

[0061]

[0062] Results: see Table 3 and image 3 The inhibitory rate of paclitaxel 10mg / kg group on human liver cancer Bel-7402 transplanted tumor in nude mice was 68.55%; the paclitaxel-raspbe...

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Abstract

The invention provides application of raspberry polysaccharide in the preparation of medicament for preventing or treating toxic and side effect of chemotherapeutics. After using chemotherapeutics, the human body certainly produces toxic side effects, such as liver, kidney and / or spleen injury. The research of the present invention find that raspberry polysaccharide can effectively reduce the side effects of organ damage caused by the chemotherapeutics, and in particular amount can reduce toxic and side effect but not reduce the curative effect of chemotherapeutics, and even enhance the curative effect, so as to provide novel options for clinical medication of cancer patients.

Description

Technical field [0001] The invention belongs to the field of medical science and technology, and specifically relates to a new use of raspberry polysaccharide. technical background [0002] Malignant tumors are still major diseases that seriously threaten human life. Recent statistics show that there are about 20 million newly discovered cancer patients in my country each year, of which 1.5 million die from cancer. Cancer deaths account for 1 / 5 of the total deaths. [0003] Currently, the most commonly used method of treating cancer is still chemotherapy. However, due to the non-specific cytotoxicity of chemical drugs, serious side effects such as bone marrow suppression, mucositis, dermatitis, diarrhea, and organ damage can occur. Due to the existence of serious side effects, many patients are reluctant to insist on treatment. How to reduce the side effects of chemotherapy drugs has always been a problem that medical personnel pay close attention to. [0004] Raspberry (Rubus i...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P39/02A23L1/09C08B37/00
Inventor 索有瑞杨永晶叶英韩丽娟
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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