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Application of salvia miltiorrhiza polysaccharide in preparation of anti-inflammatory drug

A technology of polysaccharide and Salvia miltiorrhiza, applied in application, anti-inflammatory agent, food preparation and other directions, can solve problems such as unreported

Inactive Publication Date: 2012-02-29
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the anti-inflammatory research of Danshen polysaccharide at home and abroad

Method used

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  • Application of salvia miltiorrhiza polysaccharide in preparation of anti-inflammatory drug
  • Application of salvia miltiorrhiza polysaccharide in preparation of anti-inflammatory drug
  • Application of salvia miltiorrhiza polysaccharide in preparation of anti-inflammatory drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 1 kg of Danshen medicinal material, grind it into fine powder, soak it in water for extraction once, add 15 times the volume ((V / W)) of medicinal material in water, stir at 20°C for 30 minutes, control the pH of the extract solution during the extraction process to 3-4, Filtrate to obtain the filtrate, concentrate, freeze-dry, and pulverize to obtain the Danshen polysaccharide extract. The sugar content of the extract was analyzed to be 53.56%.

[0019] The Danshen polysaccharide extract is made into tablets, capsules, chewable tablets or oral liquids according to conventional methods. Drugs used to enhance the anti-inflammatory effect.

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Abstract

The invention discloses an application of salvia miltiorrhiza polysaccharide in preparation of anti-inflammatory drug or health care products. An applicant observes influence of salvia miltirorrhiza polysaccharide to DNFB (dinitrofluorobenzene) induced mice auricle allergic reaction, influence of salvia miltirorrhiza polysaccharide to in vitro mice spleen lymphopoiesis and influence of salvia miltirorrhiza polysaccharide to expression of a DNFB induced mice contact dermatitis spleen inflammatory factor by virtue of in vitro cells and molecular biological experiments and finds that the salvia miltirorrhiza polysaccharide has anti-inflammatory effect, thus new application of the salvia miltirorrhiza polysaccharide is found.

Description

technical field [0001] The invention relates to the application of salvia miltiorrhiza polysaccharide extract in anti-inflammatory drugs. Background technique [0002] Salvia miltiorrhiza polysaccharide is a kind of component that cannot be ignored except fat-soluble diterpene components and water-soluble phenolic acids in Salvia miltiorrhiza. HPLC chromatographic analysis showed that Salvia miltiorrhiza polysaccharide is a polysaccharide compound composed of mannose, galactose, glucose, xylose, arabinose, rhamnose, glucuronic acid, galacturonic acid and some unknown monosaccharides. [0003] Salvia miltionrrhiza Bge is a dicotyledonous Lamiaceae plant. Its root is used as medicine. It mainly has the effects of dispelling blood stasis and relieving pain, promoting blood circulation and regulating menstruation, nourishing blood and calming the nerves. Abdominal pain, hepatosplenomegaly, angina pectoris embolism. [0004] Danshen polysaccharide has anti-thrombotic, anti-immu...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P29/00A23L1/30
Inventor 许定舟李金华汪涛葛发欢钟鸣刘菊妍杨丽张聪琪刘忠云
Owner GUANGZHOU HANFANG PHARMA
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