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Application of Yigong powder in preparation of drug for treating splenomegaly and mitochondrial damage caused by anemia of chronic disease, infection or inflammation disease

A technology for inflammatory diseases and Yigongsan, applied in the field of drug application, to achieve the effect of expanding indications

Inactive Publication Date: 2018-05-25
罗梅宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, erythropoiesis-stimulating agents or blood transfusions are mostly selected for correcting ACD. However, although erythropoiesis-stimulating agents can increase the utilization of iron by immature erythrocytes in some ACD patients, they can stimulate the recirculation of internal iron storage to a certain extent, and partly solve the recirculation of internal iron storage. Utilization problems still cannot completely solve ACD from the whole process of absorption, utilization and storage of iron metabolism, and some patients themselves are resistant to erythropoiesis-stimulating agents, and about 1 / 3 of patients are ineffective for erythropoiesis-stimulating agents

Method used

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  • Application of Yigong powder in preparation of drug for treating splenomegaly and mitochondrial damage caused by anemia of chronic disease, infection or inflammation disease
  • Application of Yigong powder in preparation of drug for treating splenomegaly and mitochondrial damage caused by anemia of chronic disease, infection or inflammation disease
  • Application of Yigong powder in preparation of drug for treating splenomegaly and mitochondrial damage caused by anemia of chronic disease, infection or inflammation disease

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Reference attached figure 1 The results of the spleen size changes on the 7th and 14th days after the intervention of Yigong Powder in ZIGI inflammation model mice showed that the spleen size of the mice in the Yigong Powder intervention group was significantly smaller than that of the ZIGI model group, indicating that Yigong Powder has the ability to reduce inflammation in model mice. The effect of enlarged spleen.

[0038] Table 1 Changes of spleen index 7 days and 14 days after ZIGI inflammation model mice were intervened with Yigong powder

[0039]

[0040] Among them, ** means p<0.01 compared with the control group, ΔΔ means p<0.01 compared with the ZIGI model group.

[0041] It can be seen from the above table that the spleen index of the mice in the Yigong Powder group was significantly lower than that in the model group, indicating that the Yigong Powder can reduce the spleen enlargement of the inflammatory model mice.

Embodiment 2

[0043] Reference attached figure 2 , where ** means p<0.01 compared with the control group, ΔΔ means p<0.01 compared with the ZIGI model group. The impact results show that after 7 days and 14 days of intervention with Yigong Powder, compared with the ZIGI model group, the hemoglobin of mice in the Yigong Powder intervention group increased significantly, indicating that Yigong Powder can improve anemia in ACD mice.

Embodiment 3

[0045] Reference attached image 3 The changes of damaged mitochondria in ZIGI inflammatory model mice after 7 days and 14 days after the intervention of Yigongsan can be seen, from image 3 It can be seen that the spleen tissue of the healthy control group is rich in organelles, only a small amount of mitochondria are slightly swollen, most of the mitochondria in the ZIGI model group are swollen and expanded, the cristae completely disappear, and a small amount of mitochondria undergoes autophagy to form an autophagy-lysosome structure. After 7 days of administration of Gongsan, most of the mitochondrial structure was normal, and the cristae structure was clearly visible, and a small amount of mitochondria underwent autophagy to form an autophagy-lysosome structure. After 14 days of administration of Yigongsan, the organelles were abundant, and the mitochondrial structure was complete and clearly visible . It can be seen that while protecting mitochondria, Yigongsan also cle...

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Abstract

The invention discloses an application of Yigong powder in preparation of drug for treating splenomegaly and mitochondrial damage caused by anemia of chronic disease, infection or inflammation disease. The Yigong powder is applied to prepare a drug for treating splenomegaly and mitochondrial damage caused by anemia of chronic disease, infection or inflammation disease, the adaptation disease of the formula is enlarged, and a new treatment drug is provided for these patients with uncontrolled basic disease and anemia of chronic disease. The Yigong powder can improve the effect of hemoglobin ofanemia of chronic disease (ACD), and further correct the anemia of chronic disease; meanwhile, the Yigong powder can obviously reduce the splenomegaly caused by inflammation; through reducing spleen phagocytosis to red cells, the ACD anemia can be improved; besides, the Yigong powder also can protect mitochondria and lighten the mitochondria damage caused by inflammation; through the autophagy wayof mitochondria, the injured autophagy is removed, and the influence of inflammation on an organism is reduced.

Description

technical field [0001] The invention relates to the technical field of drug application, in particular to the application of Yigong Powder in the preparation of drugs for treating anemia of chronic diseases, and the application of drugs for splenomegaly and mitochondrial damage caused by infectious or inflammatory diseases. Background technique [0002] Anemia of chronic disease (ACD) is an immune-driven disease related to inflammatory response. Anemia of chronic disease (ACD) refers to a group of anemia secondary to chronic infection, inflammation and malignant tumors, characterized by shortened red blood cell lifespan, iron metabolism disorder, inflammatory cytokines The increase leads to a decrease in erythropoietin and inhibition of the bone marrow's compensatory proliferative response to anemia. With changes in lifestyle and disease spectrum, ACD caused by non-infectious diseases (tumor, chronic kidney disease, heart failure, obesity, etc.), aging (the level of pro-infl...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/14A61P7/06A61P31/00A61P29/00A61P35/00A61P13/12A61P9/04A61P3/04
CPCA61K9/14A61K36/076A61K36/258A61K36/284A61K36/484A61K36/752A61K2300/00
Inventor 罗梅宏邹纯朴郑秦管宇闫明霞夏乐敏
Owner 罗梅宏
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