Application of black-bone chicken blood to regulation of immunity

A technology for regulating immunity and silky chickens, which can be used in applications, medical raw materials from mammals, medical raw materials from birds, etc., and can solve the problems of high price and poor quality.

Active Publication Date: 2012-03-14
CHARIOT CARNATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the active ingredients in Chinese medicinal materials usually need to be extracted through complicated procedures,

Method used

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  • Application of black-bone chicken blood to regulation of immunity
  • Application of black-bone chicken blood to regulation of immunity
  • Application of black-bone chicken blood to regulation of immunity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Preparation of silky chicken blood meal

[0024] (1) Silkie blood processing

[0025] The silky chicken was bred by Kaixin Industrial Co., Ltd. and provided for the preparation of silky chicken blood meal. The method of blood collection for silky chicken blood is to directly collect silky carotid artery blood after cutting the carotid artery after the chicken is shocked by electric shock. Put the collected silky chicken blood directly into the -20°C freezer to freeze; or it can also be placed at room temperature until it naturally coagulates into a blood clot, and then put it into the -20°C freezer for later use.

[0026] (2) Drying process

[0027] The frozen silky blood is then freeze-dried into powder, the freeze-drying conditions are -20°C, the pressure is 0.01torr, the processing time is set to 72 hours for a yield of 100 kg, and the water content is controlled below about 5%; or The powder is made by hot air drying. The hot air inlet temperature i...

Embodiment 2

[0031] Embodiment 2: experimental animal and experimental design

[0032] Male BALB / c mice were purchased from Lesco Biotechnology Co., Ltd., domesticated and quarantined for 1 to 2 weeks, and tested with 8-week-old mice. The number of experimental animals in each group was 10. This strain of experimental animals has abundant basic reference data and data, which can be applied to specific immune function evaluation tests.

[0033] The experimental animals were kept in a standard animal room with an indoor temperature of 21-25° C., a humidity of 55-75%, and a lighting time of 12 hours. After 1 to 2 weeks of domestication of the experimental animals, the experimental personnel judged to ensure that the experimental animals were in good health, and then they were weighed and divided into S-type groups. 5 animals were reared in one breeding cage, and the individual experimental animals were distinguished by ear number, and the cage number, strain, week age, animal number, test nu...

Embodiment 3

[0043] Example 3: Effect of silky chicken blood powder on body weight and spleen weight

[0044] During the test period, the clinical observation of the animals in each test group and the macroscopic lesions after sacrifice had no specific visual lesions, and there was no significant difference in body weight changes and spleen weights after sacrifice between the groups (Table 1 and Table 2), showing that silky chicken blood meal Not toxic to living organisms.

[0045] Table 1 Weight change

[0046]

[0047] Week 0: the body weight of the mice before administration of the drug on the first day of the experiment

[0048] NC: negative control group

[0049] TAL: Low-dose group of silky chicken blood meal

[0050] TAM: medium dose group of silky chicken blood powder

[0051] TAH: Silkie blood meal high dose group

[0052] PC: Shuang Hor Premium Ganoderma Lucidum Capsules

[0053] Table 2 Spleen weight

[0054] group

Dose (mg / kg)

number of animals

Sp...

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PUM

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Abstract

The invention relates to application of black-bone chicken blood powder. The black-bone chicken blood powder can be used for regulating nonspecific immunological competence, and is used for promoting production of cytokines, promoting multiplication of immune cells of the spleen and promoting the activity of natural killer cells and macrophages.

Description

technical field [0001] The present invention relates to a use for modulating immune activity. Background technique [0002] Due to the advancement of medical technology and the prolongation of human life, "population aging" has become a common problem faced by developed countries in recent years. At present, Taiwan has entered the forest of developed countries, and the phenomenon of population aging and the problems caused by it are gradually emerging. . As aging occurs, the functions of immune-related organs in the human body, including the bone marrow, thymus, spleen, and lymph nodes that produce lymphocytes, will gradually decline, increasing the risk of disease infection and death. In addition to aging, current research also shows that modern people are burdened with the immune system due to factors such as malnutrition, stress, or pollution. Under environmental stimulation, it is easy to cause abnormal secretion of cytokines and lead to chronic inflammation, which in t...

Claims

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Application Information

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IPC IPC(8): A61K35/14A61K9/14A23L1/29A61P37/02A61P37/04A23L33/00A61K35/57
Inventor 邓学凯魏敏伦曾丽芳刘姿锜
Owner CHARIOT CARNATION
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