Traditional Chinese medicine composition for treating Alzheimer's disease as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses traditional Chinese medicine composition for treating the Alzheimer's disease as well as a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises milkvetch roots, Chinese angelica, red peony roots and prince's-feather fruits. Research indicates that the traditional Chinese medicine composition can improve the spatial learning ability and the spatial exploration ability of Kunming mice suffering from the Alzheimer's disease, increase visceral indexes of brains and spleens of the mice suffering from the Alzheimer's disease, reduce the permeability of Alzheimer's disease blood brain barriers, decrease Alzheimer's disease brain tissue hippocampal Abeta, IL-6 and IL-12 protein expression levels and have no obvious effect on weight of Alzheimer's disease models, namely, the Kunming mice. The results indicate that the traditional Chinese medicine composition is good in treatment effect on the Alzheimer's disease, so that the traditional Chinese medicine composition has the broad application prospect in the field of treatment of the Alzheimer's disease.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and use, in particular to a traditional Chinese medicine composition for treating Alzheimer's disease and its preparation method and application. The invention belongs to the technical field of Chinese medicine research. Background technique [0002] Alzheimer's disease is one of the common senile diseases. It is manifested as intellectual impairment and mental disorder in the brain tissue of the body. It is a comprehensive and multiple neurodegenerative disease. The pathological manifestation of Alzheimer's disease is the deposition of a large number of amyloid plaques in the brain tissue. The main component of the plaque is β-amyloid (Aβ), and the precursor of Aβ is β-amyloid precursor protein ( APP), Aβ is a 40-42 amino acid peptide substance produced by the hydrolysis of APP by α, β, γ-secretase, mainly including Aβ 1-40 and Aβ 1-42 , where Aβ 1-40 Tox...

AI Technical Summary

Problems solved by technology

At present, the basic research of traditional Chinese medicine is relatively weak. The chemical components of the raw materials of traditional Chinese medicine are extremely complex, and the active ingredients of traditional Chinese medicine are not clear. However, traditional Chinese medicine is multi-component and multi-target. Therefore, the more the taste of the medicine, the more likely it will cause adverse reactions.

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