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Preparation method of bone restoration material containing multiple drug-loaded slow release systems

A technology for bone repair and sustained release, which is used in medical science, prosthesis, tissue regeneration, etc., and can solve problems such as non-infection.

Active Publication Date: 2017-05-31
BEIJING UNIV OF CHEM TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, excessive use of autologous bone will bring new trauma and complications to patients; allogeneic bone transplantation can overcome some of the problems caused by autologous bone transplantation, but it will be affected by the source of the donor, tissue conditions at the time of transplantation, and immunogens. Sex and other limitations; non-tissue repair surgery is usually used for joint replacement surgery, the main problem is that it cannot integrate with the surrounding tissue and form a focus of infection

Method used

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  • Preparation method of bone restoration material containing multiple drug-loaded slow release systems
  • Preparation method of bone restoration material containing multiple drug-loaded slow release systems
  • Preparation method of bone restoration material containing multiple drug-loaded slow release systems

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Take 5g of halloysite nanotubes, add 200mL of toluene solvent to ultrasonically disperse evenly, add 5mL of KH550 under toluene reflux conditions at 120°C, and react for 12 hours to obtain modified halloysite nanotubes A;

[0040] (2) Take a certain amount of bone-promoting drug icariin to react with acryloyl chloride. The molar ratio of bone-promoting drug to acryloyl chloride is 1:1. After the reaction is carried out in an ice-water bath for 12 hours, the reaction product is purified and dried to obtain C;

[0041] (3) reacting A and C under certain conditions to obtain halloysite nanotubes D grafted with bone-promoting drugs on the surface, wherein the molar ratio of A to C is 1:2;

[0042] (4) Take a certain amount of the bone-promoting drug icariin and add it to N,N-dimethylformamide (DMF), stir and ultrasonically dissolve it to obtain a saturated solution;

[0043] (5) Mix 5 g of halloysite nanotubes D with a saturated solution containing 5 g of the bone-prom...

Embodiment 2

[0053] (1) Take 5g of halloysite nanotubes, add 200mL of toluene solvent to ultrasonically disperse evenly, add 25mL of KH550 under toluene reflux conditions at 120°C, and react for 12 hours to obtain modified halloysite nanotubes A;

[0054] (2) Take a certain amount of bone-promoting drug icariin to react with acryloyl chloride. The molar ratio of bone-promoting drug to acryloyl chloride is 1:1.5. After the reaction is carried out in an ice-water bath for 12 hours, the reaction product is purified and dried to obtain C;

[0055] (3) reacting A and C under certain conditions to obtain halloysite nanotubes D grafted with bone-promoting drugs on the surface, wherein the molar ratio of A to C is 2:3;

[0056] (4) Take a certain amount of the bone-promoting drug icariin and add it to N,N-dimethylformamide (DMF), stir and ultrasonically dissolve it to obtain a saturated solution;

[0057] (5) Get 5g of halloysite nanotube D and mix with the saturated solution of icariin, ultrason...

Embodiment 3

[0067] (1) Take 5g of halloysite nanotubes, add 200mL of toluene solvent to ultrasonically disperse evenly, add 15mL of KH550 under toluene reflux conditions at 120°C, and react for 12 hours to obtain modified halloysite nanotubes A;

[0068] (2) Take a certain amount of bone-promoting drug icariin to react with acryloyl chloride. The molar ratio of icariin to acryloyl chloride is 1:1.2. After the reaction is carried out in an ice-water bath for 24 hours, the reaction product is purified and dried. get C;

[0069] (3) A and C are reacted with a mixed solvent of methanol and water (methanol volume: water volume = 4:1) at 60°C to obtain halloysite nanotubes D grafted with icariin on the surface, wherein A and The molar ratio of C is 1:1.2;

[0070] (4) Take a certain amount of growth factor bone morphoprotein (BMP) and add it to deionized water, fully stir it to dissolve it to obtain its saturated solution;

[0071] (5) Mix 5 g of halloysite nanotube D with a saturated solutio...

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Abstract

The invention relates to a preparation method of a bone restoration material containing multiple drug-loaded slow release systems, and belongs to the field of biomaterials. The preparation method comprises the following steps: adding an antibacterial medicine and halloysite nanotubes loaded with an osteogenesis promoting medicine through intracavity loading and tube outside grafting to main raw materials comprising biocompatible degradable aliphatic polyester and natural polymer, and carrying out an electrospinning technology to prepare the bone restoration material. The material has the advantages of excellent biocompatibility, controllable and long-term drug release performance, bone defect restoration promotion effect, no secondary surgery, and inhibition of bacterial infection and inflammations easily appearing after the defect.

Description

technical field [0001] The invention relates to a preparation method of a bone repair material containing a multi-drug-loaded slow-release system, which belongs to the field of biological materials, and in particular to a fiber formed by degradable aliphatic polyester as the main matrix material and loaded with antibacterial drugs and surface A bone repair material loaded with a nano-carrier of a bone-promoting drug in a grafting and internal adsorption mode and a preparation method thereof. [0002] technical background [0003] Bone defect is a very common clinical trauma, and the bone repair process is very long, which mainly includes the hematoma and inflammation phase, the initial callus reaction phase, the cartilage formation phase, and the bone formation and remodeling phase. In the process of bone repair, cells secrete a variety of growth factors to play a role in different timing to ensure the repair of bone defects. [0004] Clinically, when a bone defect occurs, t...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/50A61L27/02A61L27/18
CPCA61L27/025A61L27/18A61L27/50A61L27/54A61L2300/404A61L2300/412A61L2430/02C08L67/00
Inventor 张立群宫敏石锐池骋吴新宝田伟
Owner BEIJING UNIV OF CHEM TECH
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