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Method for preparing potato starch medicament carrier microspheres

A potato starch and drug technology, which is applied in the directions of pharmaceutical formulations, inactive medical preparations, and bulk delivery, can solve the problem of weak construction of industrial technical support systems, low overall benefits, and insufficient development of the advantages and potential of the potato industry. and other problems, to achieve the effect of neat shape, simple production process and operation, and low production cost

Inactive Publication Date: 2010-04-21
GANSU AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitations of natural conditions, economic foundation, and technological level, the construction of the industrial technology support system is weak, the superiority and potential of the potato industry have not been fully realized, and the overall benefit is low

Method used

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  • Method for preparing potato starch medicament carrier microspheres
  • Method for preparing potato starch medicament carrier microspheres
  • Method for preparing potato starch medicament carrier microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 A kind of preparation method of potato starch drug carrier microsphere comprises the following steps:

[0029] (1) Mix 14g of potato refined starch produced by Gansu Tengsheng Starch Co., Ltd. with 400ml of water, stir at room temperature to form a starch emulsion with a milk concentration of 3.5g / 100ml, and adjust the pH with a NaOH solution with a mass concentration of 2mol / L value up to 8.

[0030] (2) Move the starch emulsion into a 2L multifunctional reactor produced by Zhengzhou Jiachuang Instrument Equipment Co., Ltd., and paste the starch emulsion at a constant temperature under the conditions of gelatinization temperature of 60°C, gelatinization time of 30min, and stirring speed of 400rmp. to obtain gelatinized starch milk.

[0031] (3) In a 2L multifunctional reactor, add 12ml of edible oil and 0.12g of Span60 emulsifier to the gelatinized starch milk for every 100ml of starch milk to make an inverse emulsion.

[0032] (4) Add 0.28g of cross-lin...

Embodiment 2

[0034] Embodiment 2 A kind of preparation method of potato starch drug carrier microsphere, comprises the following steps:

[0035] (1) Mix 16g of potato starch with 400ml of water, stir at room temperature to form a starch emulsion with a milk concentration of 4.0g / 100ml, and adjust the pH value to 9 with a NaOH solution with a mass concentration of 2mol / L.

[0036] (2) Transfer the starch emulsion into a 2L multifunctional reactor, and perform constant-temperature gelatinization on the starch emulsion at a gelatinization temperature of 70° C., a gelatinization time of 25 min, and a stirring speed of 380 rpm to obtain gelatinized starch milk.

[0037](3) In a 2L multifunctional reactor, add 20ml of edible oil and 0.14g of Span60 emulsifier to the gelatinized starch milk for every 100ml of starch milk to make an inverse emulsion.

[0038] (4) In a 2L multi-functional reactor, add 0.31g of cross-linking agent N-N methylenebisacrylamide, 0.06g of sodium bisulfite, and 0.1g of am...

Embodiment 3

[0040] Embodiment 3 A kind of preparation method of potato starch drug carrier microsphere, comprises the following steps:

[0041] (1) Mix 18g of potato starch with 400ml of water, stir at room temperature to form a starch emulsion with a milk concentration of 4.5g / 100ml, and adjust the pH value to 10 with a NaOH solution with a mass concentration of 2mol / L.

[0042] (2) Transfer the starch emulsion into a 2L multifunctional reactor, and gelatinize the starch emulsion at a constant temperature under the conditions of gelatinization temperature of 80° C., gelatinization time of 10 min, and stirring speed of 350 rpm to obtain gelatinized starch milk.

[0043] (3) In a 2L multifunctional reactor, add 28ml of edible oil and 0.16g of Span60 emulsifier to the gelatinized starch milk for every 100ml of starch milk to make an inverse emulsion.

[0044] (4) In a 2L multi-functional reactor, add 0.34g of cross-linking agent N-N methylenebisacrylamide, 0.07g of sodium bisulfite, and 0.1...

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Abstract

The invention relates to a method for preparing potato starch medicament carrier microspheres, which comprises the following steps: (1) mixing potato native starch with water to form a starch emulsion with the emulsion concentration of 3.5 to 5.0g / 100ml, and adjusting the pH value to between 8 and 11; (2) performing constant temperature gelatinization on the starch emulsion to obtain a gelatinized starch emulsion; (3) adding edible oil and an emulsifying agent into the starch emulsion respectively to prepare a reversed phase emulsion; and (4) adding a crosslinking agent, sodium bisulfite and ammonium persulfate into the reversed phase emulsion respectively to perform reactions, adjusting the pH to between 8 to 11, then standing the mixture, removing the supernatant fluid, washing, drying and crushing the mixture, and passing the powder through a sieve of 80 meshes. The method has a simple production process and simple operation and is easy to grasp, the production cost is low, the pollution is less, and the potato starch medicament carrier produced by the method has a long slow-release time and a high slow-release rate.

Description

technical field [0001] The invention relates to a preparation method of starch drug carrier microspheres, in particular to a preparation method of potato starch drug carrier microspheres. Background technique [0002] my country is a large starch production and consumption country, but with the rapid development of industrial production technology, some properties of raw starch no longer meet the requirements of new equipment and new processes, and it needs to be treated to obtain better application effects Therefore, starch microspheres have become one of the research hotspots in various countries in recent years. [0003] Starch microspheres are polymer microspheres made of natural starch or starch derivatives, which are widely used in medicine, food, chemical industry and other fields. For many drugs that cannot be used directly or have unsatisfactory curative effects, they can be embedded in microspheres or adsorbed on the surface of microspheres, and the size, surface p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36C08J3/12C08J3/24
Inventor 韩舜愈蒲露梅虎玉森王文莹祝霞齐治国毕阳蒋玉梅盛文军张盛贵张波康继民张红丽
Owner GANSU AGRI UNIV
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