The invention discloses a green mixed refrigerant, comprising 20-60 wt% of 2,3,3,3-tetrafluoro propylene or trans-1,3,3,3-tetrafluoro propylene, 5-30 wt% of 1,1-difluoroethane or 1,1,1,2-tetrafluoro ethane, and 35-60 wt% of difluoromethane. The preparation method is characterized by physically mixing the above ingredients according to corresponding ratio at normal temperature. According to the invention, because the volume refrigerating capacity of the green mixed refrigerant is very close to that of HCFC-22 and the condensation pressure of the green mixed refrigerant is lower than that of R410A, the green mixed refrigerant can be directly filled in existing refrigeration, air-conditioning or heat pump sets which use HCFC-22; and when HCFC-22 is replaced, the components and pipeline of the system have no need of redesigning. The green mixed refrigerant can be an alternative refrigerant to HCFC-22 and R410A.