122 results about "Difluoroethyne" patented technology

Environmentally friendly refrigerant blends utilizing refrigerants including E-1,3,3,3-tetrafluoropropene (HFO-1234zeE), difluoromethane (HFC-32), and 1,1-difluoroethane (HFC-152a). The blends have low GWP, low toxicity, and low flammability with improved efficiency for use in a hybrid, mild hybrid, plug-in hybrid, or full electric vehicles for thermal management (transferring heat from one part of the vehicle to the other) of the passenger compartment providing air conditioning (A / C) or heating to the passenger cabin.

The present invention relates to a liquid pharmaceutical composition suitable for administration by inhalation comprising: (i) a suspension of particles comprising 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554); and (ii) a diluent which is 1,1,1,2-tetrafluoroethane (HFA-134a), wherein the liquid pharmaceutical composition is substantially free of surfactant. The invention also relates to a pressurised metered dose inhaler comprising the liquid pharmaceutical composition.

The present invention relates to an environmentally friendly refrigerant blend that utilizes a refrigerant comprising E-1, 3, 3, 3-tetrafluoropropene (HFO-1234zeE), difluoromethane (HFC-32), and 1, 1-difluoroethane (HFC-152a), and more particularly, to a refrigerant blend that uses a refrigerant comprising E-1, 3, 3, 3-tetrafluoropropene (HFO-1234zeE), difluoromethane (HFC-32), and 1, the blend has low GWP, low toxicity and low flammability as well as improved efficiency for thermal management of the passenger compartment (transferring heat from a portion of the vehicle to another) of a hybrid, mild, plug-in hybrid, or all-electric vehicle to provide air conditioning (A / C) or heating to the passenger compartment.

The invention discloses a heat transfer composition as well as a preparation method and application thereof. According to the total mass of the composition, the mass ratios of the first component, trans-1, 3, 3, 3-tetrafluoropropene and difluoromethane are x%, y% and z% respectively, the first component is 2, 3, 3, 3-tetrafluoropropene and 1, 1-difluoroethane, the ratios (x, y and z) of the first component, the trans-1, 3, 3, 3-tetrafluoropropene and 1, 1-difluoroethane are located in a ternary phase diagram, the x coordinate of a point A is 23.6%, the x coordinate of a point B is 90.0%, the point coordinates on a curve section AB are (x, 70.06-0.6395 x-0. 001538 x2 and 29.94-0.3605 x + 0.001538 x2), and the coordinates of a point C are (77.6, 0 and 22.4 The GWP of the composition does not exceed 150, the flammability grade reaches A2L, and the composition is a heat transfer composition which is used for replacing propane and is low in global warming potential value, high in refrigeration / heat efficiency and low in flammability and is suitable for refrigeration / heating application.

Provided is a working medium for a heat cycle, including trifluoroethylene, 1,1-difluoroethane, and trifluoroiodomethane, in which a proportion of 1,1-difluoroethane with respect to a total of trifluoroethylene and 1,1-difluoroethane is 57.5% by mass or less, a proportion of trifluoroiodomethane with respect to a total of trifluoroethylene, 1,1-difluoroethane, and trifluoroiodomethane is 24.5% by mass or less, and a total proportion of trifluoroethylene, 1,1-difluoroethane, and trifluoroiodomethane with respect to the working medium for a heat cycle as a whole is 75.0% by mass or more.

The invention discloses a method for preparing 1-chloro-1, 1-difluoroethane and co-producing 1, 1-difluoroethylene, which comprises the following steps: mixing 1, 1-difluoroethane, chlorine and a hot substance, preheating, introducing into a reactor, and carrying out thermal chlorination reaction to obtain 1-chloro-1, 1-difluoroethane and 1, 1-difluoroethylene, wherein the reaction temperature of the thermal chlorination reaction is 300-600 DEG C, and the reaction retention time is less than or equal to 150s. The hot substance is introduced in the hot chlorination reaction process to take away the heat of the reaction system, so that the temperature rise of the reaction system is prevented from being too fast, the reaction temperature is easy to control, and the yield of the target product is improved. Besides, the method avoids the use of a catalyst, can co-produce the downstream product 1, 1-difluoroethylene of the 1-chloro-1, 1-difluoroethane, has the advantages of simple process, high production efficiency, low production cost, continuous production and the like, and is a feasible industrial route for production.

The invention relates to the field of chemical equipment, and discloses a production device and method of 1, 1-difluoroethane. The production apparatus comprises: a reactor; a reflux tower and a first condenser, a feed inlet and a liquid phase outlet of the reflux tower are connected with the reactor, a gas phase outlet of the reflux tower is connected with the first condenser, and a gas phase outlet of the first condenser is connected with the reactor; the separation tower is connected with a liquid phase outlet of the first condenser, a liquid phase outlet of the separation tower is connected with the reactor, a gas phase outlet of the separation tower is connected with the second condenser, a gas phase outlet of the second condenser is connected with the reactor, and a liquid phase outlet of the second condenser is connected with the separation tower; and the post-treatment system is connected with the liquid phase extraction port of the separation tower. The production device can be used for separating and recycling hydrogen fluoride, reducing the content of hydrogen fluoride in the product, eliminating the consumption of fresh water and alkali liquor caused by a water alkali washing process, avoiding the generation of aqueous hydrofluoric acid with low additional value, and eliminating a heavy component removal tower.

Method of filling a pressurised dispensing container (10) with a product to be dispensed; wherein the pressurised dispensing container comprises a container (11) for the product (12) to be dispensed, and a valve fixed to the container; wherein the valve comprises a valve stem (15), a valve body and one or more seals, the valve stem being slidable within the valve body, the one or more seals co-operating with the valve stem for regulating discharge of a fluid; the valve further comprises a sealing gasket for sealing the valve to the dispensing container; and each of the one or more seals and the sealing gasket (14) comprises a polymer material comprising bromobutyl rubber; wherein the product to be dispensed comprises a propellant comprising 1,1-difluoroethane or a derivative thereof and / or 1,3,3,3-tetrafluoroprop-1-ene or a derivative thereof; and wherein the method comprises filling the container with the product to be dispensed through the valve.

The application discloses a method for preparing 1,2-difluoroethylene from 2-chloro-1,1-difluoroethane resource utilization, and the method comprises the following steps: under the action of an M-N / Y catalyst, 2-chloro-1,1-difluoroethane is subjected to a gas phase dehydrochlorination reaction to obtain 1,2-difluoroethylene, wherein M is an active component, is a fluoride and / or chloride of at least one of K, Cs, Mg, Sr or Ba; N is a metal additive, is at least one of Ru, Rh, Pd, La, Ce or Pr; and Y is a carrier, is selected from activated carbon, graphene or metal fluoride. The preparation method has the advantages of mild reaction conditions, high selectivity of target products and the like.

An azeotrope or azeotrope-like composition consists essentially of an effective amount of 1-chloro-1, 1-difluoroethane (HCFC-142b) and 1, 1, 2-trifluoroethane (HFC-143), and a method for producing the azeotrope or azeotrope-like composition. Also disclosed are methods for separating azeotrope or azeotrope-like compositions and / or utilizing the same in extraction and pressure swing distillation in conjunction with methods of making 1, 1, 2-trifluoroethane (HFC-143).

A pressurised dispensing container (10) comprising a container (11) for product to be dispensed, and a valve fixed to the container, wherein the container contains a propellant comprising 1,1-difluoroethane or a derivative thereof and optionally ethanol. The valve comprises a valve stem (15), a valve body (16, 18) and one or more seals (20, 21), the valve stem being slidable within the valve body, the one or more seals co-operating with the valve stem for regulating discharge of a fluid. The valve further comprises a sealing gasket (14) for sealing the valve to the dispensing container. The one or more seals (20, 21) is / are formed from (i) an elastomeric composition, preferably an elastomeric composition comprising an ethylene-propylene-diene terpolymer. The sealing gasket (14) is formed from (ii) an elastomeric composition comprising an isobutylene polymer or co-polymer thereof.

The invention discloses a highly efficient 1,1-difluoroethane cracking furnace equipment, including a shell, a flow bypass system, a tube-and-tube reaction system, a temperature measuring device, and a cracking gas inlet and outlet system, wherein the flow bypass system includes a baffle, and the baffle is in a spiral shape; the tube-and-tube reaction system includes tubes, the tubes are equipped with catalysts, and the ends of the tubes are sealed with a spring support structure for the catalyst part; the cracking gas inlet and outlet system includes a top air inlet pipe box and a bottom discharge pipe box, a gas distributor is installed in the top air inlet pipe box, and a separation and filtering device is installed in the bottom discharge pipe box. The present invention adopts the design of the separation and filtering device, and when the output shaft of the hydraulic cylinder rotates, the cross pipe and the cleaning brush will also rotate synchronously to clean the rectangular filter plate, and the washing liquid is sprayed through the cleaning liquid nozzle, and the cleaning liquid can be sprayed during the cleaning of the rectangular filter plate by the cleaning brush, thereby improving the cleaning effect.

The invention relates to a gas insulation technology of an electric power system, in particular to a mixed insulating gas containing perfluorodimethyl sulfide and application of the mixed insulating gas. The insulating mixed gas is composed of a component 1 and a component 2, and the component 1 is perfluoromethyl sulfide; and the component 1 is 1, 1, 2, 2-tetrafluoroethane, 2, 3, 3, 3-tetrafluoropropene and 1, 1-difluoroethane, and the component 2 is 1, 1, 2, 2-tetrafluoroethane, 2, 3, 3, 3-tetrafluoropropene and 1, 1-difluoroethane. The insulating mixed gas provided by the invention has the insulating property equivalent to or even more excellent than that of sulfur hexafluoride, has a lower GWP value, and is particularly suitable for gas-insulated electrical transformers, gas-insulated wires for transmitting or distributing electric power, or connectors / disconnectors in the middle-high voltage field. The mixed gas disclosed by the invention has the characteristics similar to that of single gas, and the liquefaction temperature of the insulating mixed gas is lower than that of each component; and the mixed gas also has an insulating synergistic effect, and has the advantages of low GWP, low toxicity, low boiling point and high insulating strength.

The invention belongs to the technical field of refrigerants, and particularly relates to a refrigerant for replacing R134a as well as a preparation method and application of the refrigerant. The refrigerant for replacing R134a is prepared from the following components in parts by weight: 60 to 80 parts of 1, 1, 1, 2-tetrafluoroethane and 20 to 40 parts of 1, 1-difluoroethane. As a refrigerant for replacing R134a, the refrigerant provided by the invention generally has the advantages of excellent environmental protection property, high refrigeration efficiency and good safety.

The invention belongs to the technical field of refrigerants, and particularly relates to an R134a alternative refrigerant as well as a preparation method and application thereof. The R134a alternative refrigerant is prepared from the following components in parts by weight: 1 to 5 parts of fluoroethane, 5 to 15 parts of 1, 1-difluoroethane and 80 to 94 parts of hexafluoropropylene. As an alternative refrigerant of R134a, the refrigerant has the advantages of being more environmentally friendly and safer on the whole.

A working medium for heat cycles, which contains trifluoroethylene, 1, 1-difluoroethane, and trifluoroiodomethane, and wherein the ratio of 1, 1-difluoroethane to the total of trifluoroethylene and 1, 1-difluoroethane is 57.5 mass% or less, and the ratio of trifluoroiodomethane to trifluoroethylene, 1, 1-difluoroethane to the total of trifluoroethylene and 1, 1-difluoroethane is 57.5 mass% or less, and the ratio of trifluoroiodomethane to the total of trifluoroethylene and 1, 1-difluoroethane is 57.5 mass% or less. The ratio of the total of trifluoroethylene, 1, 1-difluoroethane and trifluoroiodomethane is 24.5 mass% or less, and the ratio of the total of trifluoroethylene, 1, 1-difluoroethane and trifluoroiodomethane is 75.0 mass% or more relative to the entire working medium for heat cycles.

It is an object to provide a new azeotropic or azeotropic-like composition comprising HCFC-142. The present disclosure provides, as its solution, an azeotropic or azeotropic-like composition comprising a refrigerant, wherein the refrigerant comprises 2-chloro-1,1-difluoroethane (HCFC-142) and at least one additional compound selected from the group consisting of trans-1,2-dichloroethylene (HCO-1130(E)) and the like.

Metered dose inhaler device including an actuator housing (10) with a substantially hollow first portion (15) including a nozzle block, and a substantially hollow second portion (25) defining a mouthpiece and located adjacent the substantially hollow first portion. A spray orifice (45) is formed in the nozzle block (30). The spray orifice (45) defines a jet length (46) along an orifice axis. The spray orifice defines an orifice exit (49) with an orifice exit diameter (47). The jet length is at least 0.8 millimeters ("mm"). The device includes a composition including a propellant that includes 1,1-difluoroethane ("HFA-152a") or trans-1, 1,1,3-tetrafluoropropene ("HFO-1234ze(E) "), the composition located in a canister (40) disposed in the substantially hollow first portion (15). Once the composition is ejected from the orifice exit (49), the composition defines a spray pattern. The spray pattern matches that of a similar device using a propellant including 1,1,1,2,3,3,3-heptafluoropropane ("HFA-227") and a jet length less than or equal to 0.8 mm.

The invention discloses a preparation method of a photoacid generator 2-((-adamantane-1-carbonyl) oxy)-1, 1-difluoroethane-1-sulfonate diphenyl (p-tolyl) sulfonium salt, and belongs to the technical field of synthesis of photoacid generators. The preparation method comprises the following steps: dissolving methyl fluorosulfonyl difluoroacetate in isopropyl ether, adding isopropanol at normal temperature, dropwise adding triethylamine at low temperature, and performing reflux reaction after dropwise adding to prepare sulfonate; dissolving the sulfonate in isopropanol, reacting with sodium borohydride at low temperature, and reducing the contained ester group into hydroxyl to obtain a compound 1, 1-difluoro-2-hydroxyl ethanesulfonic acid sodium salt; the preparation method comprises the following steps: preparing 1-adamantanecarboxylic acid from 1-adamantanecarboxylic acid, performing esterification reaction on hydroxyl contained in the molecule and 1-adamantanecarboxylic acid under the action of trifluoroacetic acid and trifluoroacetic anhydride to prepare anions, stirring the anions and (4-methylphenyl) diphenylsulfonium trifluoromethane sulfonate in an organic solvent, and performing post-treatment and purification after the reaction is finished to obtain a pure product. The preparation steps are simple, and the reaction is efficient.

The present application relates to a refrigerant and its use, wherein the refrigerant includes a first component, a second component, a third component and a fourth component, wherein the first component is trifluoroiodomethane; the second component is 1,1,2-trifluoroethylene, the third component is propane; the fourth component includes at least one of 1,1-difluoroethane, 2,3,3,3-tetrafluoropropylene and trans-1,3,3,3-tetrafluoropropylene. In a liquid phase at room temperature and pressure, the first component, the second component, the third component and the fourth component are mixed to obtain a refrigerant, the GWP of the refrigerant is less than 50, the ODP is 0, and it has obvious environmental advantages. At the same time, the thermal performance and unit volume refrigeration capacity of the environmentally friendly mixed refrigerant are similar to those of R290. Compared with R290, the safety of the mixed refrigerant is significantly improved, and the safety level of the mixed refrigerant is better than that of R290, and it can be used in air conditioners.

The embodiment of the utility model provides a 1, 2-dibromo-2-chloro-1, 1-difluoroethane preparation system, which relates to the technical field of chemical production and comprises a reactor, one side of the reactor is connected with a washing tower through a pipeline, the lower end of the washing tower is connected with an intermediate tank through a pipeline, the lower end of the intermediate tank is communicated with a rectifying tower through a pipeline, and the rectifying tower is arranged at one end of the intermediate tank. A gas-phase material 1, 1-difluoro-2-vinyl chloride generated in the reactor is communicated to a third section of the washing tower for feeding and washing, a material at the bottom of the washing tower is fully reacted, the material enters an intermediate tank after the internal bromine content is detected to be qualified, a material in the intermediate tank is fed into the rectifying tower, and a material generated at the bottom of the rectifying tower is separated from the first condenser; according to the present invention, the 1, 2-dibromo-2-chloro-1, 1-difluoroethane is subjected to cooling and temporary storage so as to prepare the 1, 2-dibromo-2-chloro-1, 1-difluoroethane through the 1, 1-difluoro-1, 2-dichloroethane, such that the process is simple, the generation of the more intermediate products is avoided, and the production processing is convenient.

The invention provides a 1-chloro-1, 1-difluoroethane separation and purification method and device, and the method comprises the following steps: 1) carrying out deacidification-dehydration treatment on a to-be-separated mixture to obtain a first intermediate; the mixture to be separated is prepared from 1-chloro-1, 1-difluoroethane, 2-chloro-1, 1-difluoroethane, 1, 1-difluoroethane and hydrogen chloride; 2) performing pressurization treatment and heat exchange liquefaction treatment on the first intermediate to obtain a liquid-phase intermediate; and 3) sequentially carrying out light component removal treatment and heavy component removal treatment on the liquid-phase intermediate to obtain the 1-chloro-1, 1-difluoroethane, wherein a heat exchange medium of the heat exchange liquefaction treatment is derived from a reflux heavy component of the heavy component removal treatment, and the separation and purification method provided by the invention can realize high-efficiency separation of a product and improve the utilization efficiency of resources and energy.

The invention belongs to the technical field of refrigerants, and particularly relates to an R134a low-GWP substitute refrigerant as well as a preparation method and application of the R134a low-GWP substitute refrigerant. The alternative refrigerant is a mixture and is prepared from the following components in parts by weight: 45 to 55 parts of difluoromethane (R32), 8 to 12 parts of 1, 1-difluoroethane (R152a) and 36 to 44 parts of hexafluoropropylene (R1216). The refrigerant disclosed by the invention has the characteristics of good environmental protection property, high refrigerating capacity per unit volume, small temperature slippage and excellent thermodynamic property, and is particularly suitable for direct replacement of a refrigerating system, and the existing equipment does not need to be transformed.

A mixed refrigerant composition includes carbon dioxide (R-744), 2,3,3,3-tetrafluoropropene (R-1234yf) and 1,1-difluoroethane (R-152a). A content of the carbon dioxide (R-744) ranges from 1 to 10 wt. % based on a total weight of the mixed refrigerant composition, and a content of the 2,3,3,3-tetrafluoropropene (R-1234yf) ranges from 65 to 95 wt. % based on the total weight of the mixed refrigerant composition, and a content of the 1,1-difluoroethane (R-152a) ranges from 1 to 30 wt. % based on the total weight of the mixed refrigerant composition. A boiling point at 1 atm of the mixed refrigerant composition ranges from −65 to −30° C.

An object of the present disclosure is to provide a method for producing HCFC-142, which is a target product, with high yield and high efficiency, by preventing the decomposition of starting materials, such as HCC-140 and HCO-1130. A method for producing HCFC-142, comprising bringing a chlorine-containing compound into contact with hydrogen fluoride in the presence of a stabilizer to perform at least one fluorination reaction, thus obtaining a reaction gas containing HCFC-142, hydrogen chloride, and hydrogen fluoride.

The invention relates to the technical field of organic chemistry, in particular to triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate as well as a preparation method and application of the triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate. The structural formula of the triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate is as shown in formula (I), and the preparation method of the triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate as shown in formula (I) comprises the following steps: taking ethyl 3-bromo-2, 2-difluoropropionate and 1, 3-adamantanediol as initial reaction raw materials, and carrying out a reaction at the temperature of 60-80 DEG C for 1-2 hours; the triphenylsulfonium 1-[[(3-hydroxy-1-adamantyl) oxy] carbonyl]-2, 2-difluoroethane sulfonate shown in the formula (I) is obtained through ester exchange reaction, substitution reaction, oxidation reaction and coordination reaction. The preparation method is simple, the reaction system is green and environment-friendly, the selectivity is good, the preparation cost is low, the product yield is high, and the method is suitable for industrial production.

The invention relates to a raw material acetylene dehydration device for preparing high-purity difluoroethane, which is characterized in that an acetylene storage tank I (4) is communicated with an acetylene delivery pump (6), the acetylene delivery pump (6) is connected with a positive water seal device (1), and the positive water seal device (1) is upwards connected with an input port I (11) of an acetylene freezing dehydrator (2) through a pipeline III (9); an output port I (12) of the acetylene freezing dehydrator (2) is upwards communicated with an input port II (13) of the acetylene cryogenic dehydrator (3), an output port II (14) of the acetylene cryogenic dehydrator (3) is upwards sequentially communicated with the dryer combination and the acetylene storage tank II (15), and the acetylene storage tank II (15) is communicated with the fluorination reactor (16). According to the method, the raw material acetylene is subjected to water ring compression, freeze dehydration, cryogenic dehydration, acetylene drying and the like, so that water in the acetylene can be more effectively removed, the service life of a catalyst is prolonged, and corrosion of a fluorination reactor is reduced.

1. A pharmaceutical composition deliverable from a metered dose inhaler, the pharmaceutical composition comprising: a propellant of pharmaceutical grade 1,1-Difluoroethane (HFC-152a); a plurality of active agent particles; and a plurality of phospholipid particles comprising perforated microstructures; wherein the active agent particles comprise an active agent selected from a long-acting muscarinic antagonist (LAMA), a long-acting P2-agonist (LABA), a short-acting beta-agonist (SABA), an inhaled corticosteroid (ICS), and a non-corticosteroid anti-inflammatory agent. A metered dose inhaler comprising a canister with an outlet valve including an actuator for dispensing a metered amount of said pharmaceutical composition, wherein the canister contains the pharmaceutical composition. Said composition for use in the treatment of a pulmonary disease or disorder.

A composition comprising 1,1-difluoroethane, propane, and at least one substance selected from the group consisting of trifluoroethylene and trans-1,2-difluoroethylene, wherein the total content of 1,1-difluoroethane, propane, and trifluoroethylene or trans-1,2-difluoroethylene is 90.0 mass % or more with respect to the total amount of the composition, the global warming potential is at most 65, and the heat of combustion is at most 28.000 MJ / kg.

A process includes contacting 1,2-dichloro-1,2-difluoroethane (HCFC-132) with an activated zinc powder in the presence of a catalyst and a solvent and producing a product mixture comprising E-1,2-difluoroethylene (HFO-E-1132) and Z-1,2-difluoroethylene (HFO-Z-1132). In some embodiments, the catalyst includes tetrabutylammonium bromide. In some embodiments, the catalyst includes zinc chloride. In some embodiments, the catalyst includes zinc acetate.