549 results about "Cryogenic temperature" patented technology

A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof. The particulate acellular tissue may further include growth and stimulating agents selected from epidermal growth factor, fibroblast growth factor, nerve growth factor, keratinocyte growth factor, platelet derived growth factor, vasoactive intestinal peptide, stem cell factor, bone morphogetic proteins, chondrocyte growth factor and combinations thereof. Other pharmaceutically active compounds may be combined with the rehydrated particulate material including: analgesic drugs; hemostatic drugs; antibiotic drugs; local anesthetics and the like to enhance the acceptance of the implanted particulate material. The particulate material product may also be combined with stem cells selected from mesenchymal stem cells, epidermal stem cells, cartilage stem cells, hematopoietic stem cells and combinations thereof.

A cryogenic tank assembly has a pump which discharges into an accumulator which is located in the cryogenic storage area. This reduces the space required for the device as well as the functioning of the device. The high pressure fluid in the accumulator remains at a cryogenic temperature. The system may also include a heater to deliver high pressure gas form the liquid storage volume.

A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed, with their larger planar surfaces, in contact with each other.

The present invention provides devices and methods for the cryogenic storage of biological material. Devices of the invention are useful for storing material at a cryogenic temperature. The devices include a temperature chamber defined by a thermally-conductive container and at least one layer of thermal insulation surrounding the thermally-conductive container. Some embodiments utilize one or more heat sources thermally connected to the thermally conductive container. Other embodiments are arranged so that no net flow of heat occurs from the temperature chamber when the temperature chamber is at a set target temperature. Also provided are methods of using the devices.

A zero boiloff cryogen cooled recondensing superconducting magnet assembly including superconducting magnet coils suitable for magnetic resonance imaging including a cryogen pressure vessel to contain a liquid cryogen reservoir to provide cryogenic temperatures to the magnet coils for superconducting operation; a vacuum vessel surrounding the pressure vessel and spaced therefrom; a first thermal shield surrounding and spaced from the pressure vessel; a second thermal shield surrounding and spaced from the first thermal shield and intermediate the vacuum vessel and the first shield; a cryocooler thermally connected by a first and a second thermal interface to the first and second thermal shields, respectively; a recondenser positioned in the space between the pressure vessel and the first thermal shield and thermally connected by a thermal interface to the cryocooler to recondense, back to liquid, cryogen gas provided from the pressure vessel; and means for returning the recondensed liquid cryogen the pressure vessel; wherein the second thermal shield surrounding the first thermal shield reduces a radiation heat load from the first thermal shield to the pressure vessel lowering boiloff of cryogen gas under conditions of failure or power off of the cryocooler.