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536 results about "Cryogenic temperature" patented technology

The cryogenic temperature range has been defined as from −150 °C (−238 °F) to absolute zero (−273 °C or −460 °F), the temperature at which molecular motion comes as close as theoretically possible to ceasing completely.

Particulate acellular tissue matrix

A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof. The particulate acellular tissue may further include growth and stimulating agents selected from epidermal growth factor, fibroblast growth factor, nerve growth factor, keratinocyte growth factor, platelet derived growth factor, vasoactive intestinal peptide, stem cell factor, bone morphogetic proteins, chondrocyte growth factor and combinations thereof. Other pharmaceutically active compounds may be combined with the rehydrated particulate material including: analgesic drugs; hemostatic drugs; antibiotic drugs; local anesthetics and the like to enhance the acceptance of the implanted particulate material. The particulate material product may also be combined with stem cells selected from mesenchymal stem cells, epidermal stem cells, cartilage stem cells, hematopoietic stem cells and combinations thereof.
Owner:LIFECELL

Hand-held, heat sink cryoprobe, system for heat extraction thereof, and method therefore

A cryoprobe system utilizing a monolithic, insulated, hand-held thermal mass having an exposed tip for cryosurgical applications and the like, as well as a heat extraction base configured to interface with the thermal mass to quickly and efficiently reduce the heat of the thermal mass to cryogenic temperatures. The heat extraction base of the preferred embodiment of the present invention is configured to interface with the tip of the thermal mass, such that the tip plugs in securely to the base, to permit an efficient thermal transfer of heat from the thermal mass through the base via a heat exchange system communicating with the base which employs a low temperature cryo-refrigeration unit. The cryo-refrigeration unit may comprise a single low temperature cooling unit to reduce the temperature of the base to around minus one hundred degrees Centigrade utilizing off-the-shelf cryogenic refrigeration methods, or may utilize a series of more conventional refrigeration units in a primary and secondary heat extraction arrangement, which method may further utilize thermocouple or Peltier effect device assist to further reduce the temperature of the heat extraction base to the required temperature. Also claimed is the method of cryosurgery employing the device(s) of the present invention.
Owner:CRYOPEN

Cooling methods

A superconducting system comprises a superconducting coil (3) mounted in a support (12). The coil is surrounded by a cryogen chamber (17) which is located radially outwardly from the coil (3) on the other side of the support (12). The cryogen chamber is in fluid communication with a cryogen recondensing unit (33) whereby vaporized cryogen may flow from the cryogen chamber (17) to the cryogen recondensing unit (33) to be recondensed in use before returning to the cryogen chamber. Thermally conductive means (25) is arranged to facilitate heat transfer from the superconducting coil (3) to the cryogen chamber (17) to vaporize cryogen contained therein in use and thereby remove heat from the coil. The thermally conductive means (25) is highly thermally conductive at cryogenic temperatures. In use, the highly thermally conductive means (25) facilitates transfer of heat from the coil (3) to the interior of the cryogen chamber (17) to vaporize cryogen located therein. A thermal conduction path is therefore used to transfer heat from the coil to the cryogen in the cryogen chamber. Cryogen vaporized in the cryogen chamber then flows to the cryogen recondensing unit (33) to be recondensed before returning to the chamber, while the vaporized cryogen acts as the heat transfer medium over the longer distance between the cryogen chamber and the recondensing unit.
Owner:TESLA ENG

Method for preparing high-strength heat-resistant and cold-resistant modified polypropylene pipe

The invention discloses a method for preparing a high-strength heat-resistant and cold-resistant modified polypropylene pipe. The pipe is formed by the following steps of: extruding an outer layer, a middle transition layer and an inner wall layer onto the same one mold through three extruders, fusing and compounding. The outer layer of the pipe consists of modified polypropylene, an impact-resistant modifying agent, an antibacterial agent, a light stabilizer, an antioxygen, a compatibilizer, nanometer materials, a tackifier and a color masterbatch in parts by weight; the middle transition layer of the pipe consists of engineering plastics, the modified polypropylene, the compatibilizer, the a tackifier and the color masterbatch in parts by weight; and the inner wall layer of the pipe consists of the engineering plastics, the modified polypropylene, the compatibilizer, a fortifier, a filler, the nanometer materials and the color masterbatch in parts by weight. Compared with traditional similar pipes, the operating temperature of the pipe prepared by the method disclosed by the invention is improved by 30-70 DEG C; the cold-resistant temperature is lowered by minus 15-minus 30 DEG C; the pressure-resistant property is improved by 30-50 percent; the creep resistance is improved by 100-200 percent; the service life is prolonged by 10-20 years; and the wall thickness of the pipe is reduced by 20-50 percent.
Owner:HONGYUE PLASTIC GROUP

Hand-held, heat sink cryoprobe, system for heat extraction thereof, and method therefore

A cryoprobe system utilizing a monolithic, insulated, hand-held thermal mass having an exposed tip for cryosurgical applications and the like, as well as a heat extraction base configured to interface with the thermal mass to quickly and efficiently reduce the heat of the thermal mass to cryogenic temperatures. The heat extraction base of the preferred embodiment of the present invention is configured to interface with the tip of the thermal mass, such that the tip plugs in securely to the base, to permit an efficient thermal transfer of heat from the thermal mass through the base via a heat exchange system communicating with the base which employs a low temperature cryo-refrigeration unit. The cryo-refrigeration unit may comprise a single low temperature cooling unit to reduce the temperature of the base to around minus one hundred degrees Centigrade utilizing off-the-shelf cryogenic refrigeration methods, or may utilize a series of more conventional refrigeration units in a primary and secondary heat extraction arrangement, which method may further utilize thermocouple or Peltier effect device assist to further reduce the temperature of the heat extraction base to the required temperature. Also claimed is the method of cryosurgery employing the device(s) of the present invention, and a heat pipe appliance to engage a remote treatment area.
Owner:CRYOPEN

Systems and methods for cell preservation

The present invention generally relates to devices and methods for the preservation of cells using drying, freezing, and other related techniques. In one set of embodiments, the invention allows for the preservation of cells in a dried state. In another set of embodiments, the invention allows for the preservation of cells within a glass or other non-viscous, non-frozen media. In some embodiments, the invention allows for the preservation of cells at temperatures below the freezing point of water, and in some cases at cryogenic temperatures, without inducing ice formation. The cells, in certain embodiments, may be preserved in the presence of intracellular and / or extracellular carbohydrates (which may be the same or different), for example, trehalose and sucrose. Carbohydrates may be transported intracellularly by any suitable technique, for example, using microinjection, or through non-microinjected methods such as through pore-forming proteins, electroporation, heat shock, etc. In certain instances, the glass transition temperature of the cells may be raised, e.g., by transporting a carbohydrate intracellularly. In some cases, the cells may be dried and / or stored, for example, in a substantially moisture-saturated environment or a desiccating environment. The cells may also be stored in a vacuum or a partial vacuum. The cells may be protected from oxygen, moisture, and / or light during storage. In certain cases, an inhibitor, such as a cell death inhibitor, a protease inhibitor, an apoptosis inhibitor, and / or an oxidative stress inhibitor may be used during preservation of the cells. The cells may be stored for any length of time, then recovered to a viable state, e.g., through rehydration, for further use.
Owner:THE GENERAL HOSPITAL CORP
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