The invention discloses a 
signal conditioning circuit for an acceleration sensor with a high g value. The 
signal conditioning circuit is composed of an isolation amplification circuit, an alternating-current coupled circuit, a first 
voltage following circuit, a 
voltage bias circuit, a low-pass filter circuit and a second 
voltage following circuit sequentially connected in series; the isolation amplification circuit is used for performing 
signal isolation amplification and power supply isolation of a sensing signal 
Signal_in output by the acceleration sensor with the high g value and then outputting an isolation amplified signal 
Signal_out1; and the low-pass filter circuit is a unit 
gain two-order voltage-controlled 
voltage source low-pass filter circuit constructed by utilizing an integrated 
operational amplifier. According to the invention, the signal waveform can be improved; frequency 
confusion while discretizing is prevented; adverse effects of 
noise are overcome in the event that the signal and a 
noise spectrum are not overlapped; the 
signal to noise ratio is increased; furthermore, aiming at different 
attack targets, sensor signals can be effectively modified; preceding-stage analogue signals easy to identify and process are provided for a burst 
control algorithm precisely damaged by a hard target penetration warhead; and the 
signal conditioning circuit can stably work in a 100000g 
impact environment.