The invention discloses a big data signal transmission anti-interference circuit comprising a high frequency component increasing circuit, a feedback anti-interference circuit and a stable output circuit, wherein the high frequency component increasing circuit receives a signal in a big data signal transmission channel, the feedback anti-interference circuit adopts an inductor L3 and an inductor L4 for filtering, meanwhile, an inductor L5, an inductor L6, a capacitor C6, a diode D2 and a capacitor C7 are designed to form a Z-type anti-interference circuit, a signal output by the Z-type anti-interference circuit is fed back by an operational amplifier AR1 to serve as a control signal to adjust the high frequency component increasing circuit, the stable output circuit receives the signal output by the feedback anti-interference circuit, a triode Q3, a triode Q4 and a voltage stabilizing diode ZD1 are used for constituting a voltage stabilizing circuit to stabilize the voltage, meanwhile,a slide rheostat RW2 is designed to adjust the voltage stabilizing value of the voltage stabilizing circuit, and finally the voltage stabilizing value is input into a control terminal of big data signals, thereby effectively improving the anti-interference property of the big data signals and stabilizing the signals.