47results about How to "Reduce blood volume" patented technology

The disclosed embodiments relate to a system and method for monitoring patient data. An exemplary method comprises obtaining plethysmographic pulse variation data that corresponds to a variation in a plethysmographic pulse of a patient, searching the plethysmographic pulse variation data for an indication of a reduction of venous return in response to a maneuver on or by the patient, and generating an output if the indication of the reduction of venous return is detected.

An interventional catheter assembly comprises an operating head for removing obstructive material from a target site in a body lumen or cavity and at least one aspiration port located proximal to the operating head and penetrating the catheter assembly, the aspiration port being in communication with a sealed lumen that communicates with a vacuum system for withdrawing aspirate fluid and obstructive material from the target site. The interventional catheter incorporates an elongated guidewire lumen bushing extending proximally from a distal region of the operating head to reduce the clearance between the guidewire and the internal surface of the guidewire lumen during operation of the interventional catheter. This feature restricts entry of fluid and debris into the guidewire lumen and promotes maintenance of consistent and high aspiration pressure and volume during operation of the aspiration system and interventional catheter assembly.

Apparatus and methods for perfusing ischemic myocardium, and optionally, for reducing the load on a patient's left ventricle, are provided using a inlet conduit having an inlet end configured for insertion into an oxygenated blood source, including without limitation, the left atrium, left ventricle, aorta, pulmonary vein, subclavian artery, brachiocephalic artery, radial artery or femoral artery, coupled to an outlet conduit having an outlet end configured for insertion into the coronary venous vasculature via the coronary ostium. The inlet conduit may include a stylet or elastomeric sleeve that facilitates placement, while the outlet conduit may include a valve for limiting a peak pressure attained in the coronary venous system. A motor-driven or hydraulically-actuated pump optionally may be coupled in the flow path, and control circuitry provided to control the pump with a user selected duty cycle.

A device for degassing gas bubbles out of a liquid comprises a housing having a liquid inlet, a liquid outlet and a gas bubble outlet. The housing includes a spiral wall defining a spiral flow path for the liquid and a hydrophobic membrane above the spiral wall and between the spiral wall and the gas bubble outlet. The spiral wall forces inward liquid entering the housing through the inlet into a spiral flow along the spiral flow path, and causes an upward flow of the gas bubbles toward the hydrophobic membrane. A method for degassing gas bubbles out of a liquid, e.g., blood, e.g., during hemodialysis, hemofiltration and hemodiafiltration, and use of such a degassing device in an extracorporeal circuit for degassing gas bubbles out of liquid, e.g., blood, e.g., during hemodialysis, hemofiltration and hemodiafiltration, are disclosed.

The lack of safe, reliable, automated and clinically acceptable blood sampling has been the main problem precluding the development of real-time systems for blood analysis and subsequent closed-loop physiological function control. While the analysis of a static blood sample in laboratory conditions has been rapidly advancing in reliability and blood volume reduction, non-invasive real-time blood analysis performed in vivo (while the blood is circulating in the body) has been elusive and unreliable. In this study we propose an innovative idea for semi-invasive blood sampling and analysis, which resembles the operation of a mosquito. At a miniature scale the proposed system does penetrate the skin to extract a static blood sample for further analysis, but the extent of this penetration, and the fact that it can be made painless, is particularly attractive for such applications as automated glucose analysis for closed-loop control of insulin infusion (artificial pancreas), continuous drug monitoring, or even periodic DNA analysis for security and identification purposes. These design aspects are described, and a specific implementation, applying MEMS (Micro Electro Mechanical Systems) technology, is suggested. The proposed microsystem is a matrix of individually controllable e-Mosquito™ cells, packaged in a disposable patch and attached to the skin, could be an avenue for real-time semi-invasive blood analysis and diagnostics.

Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.

A waterless blood heater/cooler device directly controlling temperature of blood flowing through an extracorporeal blood circuit. A thermoelectric module is coupled to a supply voltage to generate a temperature difference. A heat exchanger cassette comprising a core and first and second laminar flow guides is in thermal contact (directly or indirectly) with the thermoelectric module. The cassette has a plurality of tubes for carrying parallel channels of the blood. The first and second laminar flow guides provide an inlet and an outlet for coupling to the extracorporeal blood circuit and respective intermediate chambers for receiving respective ends of the tubes in order to guide the blood to and from respective tubes in a substantially laminar flow.

Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorporating depletion and addition devices are provided to optimize the preparation, storage and transfusion of blood products to a recipient are described.

Described is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit, the apparatus having an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus, the apparatus comprising: a core in communication with the inlet such that blood from a patient can be supplied to the core, the core comprising a first element and a second element that interfit to define openings, wherein the elements and the openings together enhance flow of blood from the patient radially outward from the core; a heat exchanger that is arranged about the core and through which blood from the core can move radially outward; and an oxygenator that is arranged about the heat exchanger and through which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.

A measurement system and method for measuring at least one parameter in a body tissue comprise at least one measurement device to be applied to the body, an optical unit for emitting light waves, wherein at least one wavelength of the light waves lies in the region of the absorption of a body parameter, at least one light guide between the optical unit and the measurement device in order to transmit light waves, and an evaluation unit for evaluating measurement waves. Light waves emitted by the optical unit can be beamed into an optical measurement volume in the body tissue by means of the measurement device, and measurement waves received by the measurement device from the measurement volume can be transmitted from the body tissue to the evaluation unit. The evaluation unit comprises a transformation algorithm, which transforms pulsatility of a body parameter measured in the measurement volume into a parameter of the pressure in the body tissue, wherein the body parameter is measured by determining the absorption of the light waves.

Disclosed are a test strip and a method for measuring medical data. The test strip comprises an upper cover having one or more application holes; a lower support having one or more detected parts at positions corresponding to detecting units of the measuring apparatus; an erythrocyte and LDL cholesterol-filtering layer designed to filter off both of erythrocytes and LDL cholesterol from an applied blood sample by agglutinating erythrocytes and precipitating LDL cholesterol; and a reaction layer in which the blood sample free of erythrocytes and LDL cholesterol is reacted with an reagent, the filtering layer and the reaction layer being stacked between the lower support and the upper cover. Structured to filter off erythrocytes and low-density lipoprotein (LDL) cholesterol from a blood sample in a single layer, the test strip of the present invention can be made to be slim and allows a low volume of blood to be analyzed.

The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in a subject, which comprise administering to the subject a therapeutically effective amount of a PEGylated albumin.

The present invention is related to a spectrum analytical method for quantifying hear-lung interaction, which can estimate cardiac function by using a heart-associated monitoring signal. According to the method of the present invention, quantification of heart-lung interaction is conducted by choosing spectrum signals within a specified frequency band, such that the interference to the heart-associated monitoring signals by incidental events occurring at a low frequency, can be avoided. Therefore, the method of the present invention can be performed even in the subjects who are not in a state of general anesthesia or sedation, and hence is very useful in estimating the cardiac function of the test subjects.

Method, system and software product for identifying high risk pregnancies comprising the step of generating a spectrogram from ultrasound Doppler signals reflected from the uterine artery and determining the maximum frequency envelope of said spectrogram, and of defining a systolic part and a diastolic part of the maximum frequency envelope and calculating an area ratio under said systolic and diastolic part (AR). This area ratio relates to the blood volume in the uterine artery.

An apparatus for enhancing erection of a penis includes an expandable first member that partially encircles an upper portion of the penis and partially constricts at least a first vein of the penis to reduce the volume of blood carried away from the penis via the first vein. A second member is mounted to the first member includes left and right shoulder sections configured to contact the penis shaft along the left and right sides the urethra. A contoured section is formed between and extends outwards away from the shoulders so that, when the shoulder sections contact the penis shaft and the first member encircles at least partially encircles the upper portion of the penis, the contoured section extends over and does not constrict the urethra.

The invention relates to medical therapy of detrimental lesions. A system treats with non-invasive arrays of non-ionizing energy-radiation sources. The external sources focus energy dose distribution to a selected volume in a body. Energy output is directed towards a pathologic location and quenched around other sites or healthy tissue. Beam aiming is done without source movement. Targeted, volumetrically discrete energy deposition can beneficially manipulate lesions within the body. The purpose of the focused and enhanced energy deposition is to repair or disable pathologic physiology or structures, nerve pathways, extracellular fluid, and misfolded proteins. Locally augmented energy is used to enhance immunity, release pharmaceutical compounds from energy-sensitive vesicles and reconfigure or eliminate misfolded proteins and their aggregates. Targeted tissue may have enhanced sensitivity to received energy via a non-ionizing-radiation, treatment-localizing agent. This system optimizes delivery of non-ionizing, non-ablating electromagnetic or mechanical energy, degrading or repairing an abnormality upon interaction with it.

The present invention relates to a medicament, in particular to a pharmaceutical preparation for the treatment of severe acute and chronic injuries in the human body which lead to hypovolemia and changes in blood function properties marked by immunodeficiency . The invention provides a plasma substitute composition with immune regulating effect. The present invention provides an application of a specific biologically active component, wherein the biologically active component is a physiologically available sodium salt of a DNA derivative, preferably a sodium salt prepared from animal raw materials such as sturgeon or salmon semen. The above composition is used for adjuvant therapy of activating hematopoietic cell generation and bone marrow cell generation without any side effect or complication.